Free Radicals in Biology V3

Free Radicals in Biology V3

1st Edition - November 23, 1977

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  • Editor: William Pryor
  • eBook ISBN: 9780323155670

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Free Radicals in Biology, Volume III reviews diverse topics in free radical biology and relates the results of chemical and biochemical investigations to clinical situations. It attempts to bridge the gap between chemical investigations and the medical applications and implications of free radical reactions. Topics covered range from radiation chemistry to biochemistry, biology, and medicine. Comprised of seven chapters, this volume begins with a general introduction to the technique of radiation chemistry; the thermodynamics and kinetic factors that need be considered; the use of pulse radiolysis and flow techniques; and the application of these methods to free radicals of biological interest. The reader is then introduced to the pulse radiolysis method and the mechanisms of carbon tetrachloride toxicity. Subsequent chapters discuss the morphological, histochemical, biochemical, and chemical nature of lipofuscin pigments; production of free radicals from the reactions of selected enzymes with their substrates; and the damage caused to skin by sunlight. The final chapter deals with the involvement of free radicals in chemical carcinogenesis. This monograph will be of value to chemists, biologists, and physicians.

Table of Contents

  • List of Contributors

    General Preface

    Preface to Volume III

    Contents of Other Volumes

    Chapter 1 Application of Radiation Chemistry to Biology

    I. Introduction

    II. Radiations and Their Interaction with Matter

    III. Sources of Radiation

    IV. The Radiolysis of Water

    V. Kinetics of Free-Radical Reactions

    VI. Pulse Radiolysis

    VII. Special Systems

    VIII. Flow Radiolysis

    IX. Some Free Radicals of Biological Interest


    Chapter 2 Free Radicals in Biology: The Pulse Radiolysis Approach

    I. Introduction

    II. The Time Scale of Radiation Action

    III. Water Radiolysis as an Experimental Tool

    IV. Amino Acids and Enzymes

    V. Electron-Transfer Reactions

    VI. The Nucleic Acids


    Chapter 3 Chemical Mechanisms in Carbon Tetrachloride Toxicity

    I. Introduction

    II. Dependence of CCl4 Toxicity on CCl4 Metabolism

    III. Cleavage of the CCl3—Cl Bond

    IV. The Lipid Peroxidation Hypothesis

    V. Biology of Lipid Peroxidation

    VI. Obligatory Role of Lipid Peroxidation in Liver Injury Induced by CCl4 and the Problem of Action at a Distance

    VII. Summary


    Chapter 4 Lipofuscin: Fine-Structural and Biochemical Studies

    I. Introduction

    II. Fine-Structural Studies

    III. Histochemical Investigations

    IV. Chemical Studies

    V. Chemical Nature of the Chromophore Present in Lipofuscin

    VI. Biogenesis of Lipofuscin

    VII. Influence of Lipofuscin Accumulation on Cell Function

    VIII. Effects of Meclofenoxate on the Lipofuscin of Experimental Animals

    IX. Conclusions


    Chapter 5 Free Radicals in Enzyme-Substrate Reactions

    I. Introduction

    II. Detection of Free Radicals: Historical Survey

    III. Kinetics Using esr Spectroscopy

    IV. One-Electron and Two-Electron Transfers in Enzyme Catalysis

    V. Reactivity of Free Radicals

    VI. Physiological Aspects of Free-Radical Reactions


    Chapter 6 The Pathological Effects of Light on the Skin

    I. Introduction

    II. Spectral Considerations

    III. Photosensitivity

    IV. Acute Pathological Effects of Sunlight on the Skin

    V. Melanin Pigmentation

    VI. Vitamin D

    VII. Chronic Sunlight Injury to the Skin (Solar Degeneration)

    VIII. Carcinogenesis

    IX. Diseases Characterized by Photosensitivity

    X. Conclusions


    Chapter 7 The Involvement of Free Radicals in Chemical Carcinogenesis

    I. Introduction

    II. Chemical Studies on Carcinogenic Compounds

    III. Metabolic Activation

    IV. Free Radicals Found in Malignant Tissues

    V. Effects of Antioxidants on Carcinogenesis

    VI. Concluding Remarks


    Subject Index

Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: November 23, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323155670

About the Editor

William Pryor

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