Free Radicals in Biology V3

List of Contributors

General Preface

Preface to Volume III

Contents of Other Volumes

Chapter 1 Application of Radiation Chemistry to Biology

I. Introduction

II. Radiations and Their Interaction with Matter

III. Sources of Radiation

IV. The Radiolysis of Water

V. Kinetics of Free-Radical Reactions

VI. Pulse Radiolysis

VII. Special Systems

VIII. Flow Radiolysis

IX. Some Free Radicals of Biological Interest

References

Chapter 2 Free Radicals in Biology: The Pulse Radiolysis Approach

I. Introduction

II. The Time Scale of Radiation Action

III. Water Radiolysis as an Experimental Tool

IV. Amino Acids and Enzymes

V. Electron-Transfer Reactions

VI. The Nucleic Acids

References

Chapter 3 Chemical Mechanisms in Carbon Tetrachloride Toxicity

I. Introduction

II. Dependence of CCl4 Toxicity on CCl4 Metabolism

III. Cleavage of the CCl3—Cl Bond

IV. The Lipid Peroxidation Hypothesis

V. Biology of Lipid Peroxidation

VI. Obligatory Role of Lipid Peroxidation in Liver Injury Induced by CCl4 and the Problem of Action at a Distance

VII. Summary

References

Chapter 4 Lipofuscin: Fine-Structural and Biochemical Studies

I. Introduction

II. Fine-Structural Studies

III. Histochemical Investigations

IV. Chemical Studies

V. Chemical Nature of the Chromophore Present in Lipofuscin

VI. Biogenesis of Lipofuscin

VII. Influence of Lipofuscin Accumulation on Cell Function

VIII. Effects of Meclofenoxate on the Lipofuscin of Experimental Animals

IX. Conclusions

References

Chapter 5 Free Radicals in Enzyme-Substrate Reactions

I. Introduction

II. Detection of Free Radicals: Historical Survey

III. Kinetics Using esr Spectroscopy

IV. One-Electron and Two-Electron Transfers in Enzyme Catalysis

V. Reactivity of Free Radicals

VI. Physiological Aspects of Free-Radical Reactions

References

Chapter 6 The Pathological Effects of Light on the Skin

I. Introduction

II. Spectral Considerations

III. Photosensitivity

IV. Acute Pathological Effects of Sunlight on the Skin

V. Melanin Pigmentation

VI. Vitamin D

VII. Chronic Sunlight Injury to the Skin (Solar Degeneration)

VIII. Carcinogenesis

IX. Diseases Characterized by Photosensitivity

X. Conclusions

References

Chapter 7 The Involvement of Free Radicals in Chemical Carcinogenesis

I. Introduction

II. Chemical Studies on Carcinogenic Compounds

III. Metabolic Activation

IV. Free Radicals Found in Malignant Tissues

V. Effects of Antioxidants on Carcinogenesis

VI. Concluding Remarks

References

Subject Index