Free Radicals in Biology, Volume 1, provides an introduction to some of the basic concepts of free radical biology. The book emerged from the President's Symposium of the American Society for Experimental Pathology held in Atlantic City in April 1970.
The book's opening chapter introduces a mechanistic view of free radical reactions using examples from biological systems. This is followed by a discussion of autoxidative damage to lipids in membranes. Some of the special chemistry of lipid oxidation are presented, and a number of novel ideas are suggested. The third chapter deals with the uses of electron-spin resonance in biology. Spin labeling is also discussed, which is one of the most useful methods of probing the chemical and physical environment of molecules in cells. The remaining chapters cover free radicals which occur in photosynthesis and the importance of the enzyme, superoxide dismutase. The study of the occurrence and reactions of this enzyme provides an important and extensive body of data clearly pointing to the significance of free radicals in cellular chemistry.
List of Contributors General Preface Preface Contents of Volume II Chapter 1 The Role of Free Radical Reactions in Biological Systems I. Introduction II. The Nature of Free Radicals III. Possible Mechanisms for the Initiation of Radical Reactions in Vivo IV. Termination Reactions V. Propagation Reactions VI. One-Electron versus Two-Electron Transfers References Chapter 2 Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes I. Formation of Free Radicals in Lipids II. Formation of Free Radicals in Lipid Membranes in Vitro III. Formation of Free Radicals in Lipid Membranes in Vivo References Chapter 3 Applications of Electron Spin Resonance in Biology I. Introduction II. A Brief Description of esr as Applied to Free Radicals III. Some Additional Experimental Considerations IV. A Few Worked Examples of Biological Free Radicals or Their Reactions Elucidated by esr References Chapter 4 Spin Labeling I. Introduction II. Essentials of the Method III. A Look at General Biological Applications IV. Conclusion References Chapter 5 Free Radicals in Photosynthesis I. Introduction II. Bacterial Photosynthesis III. Primary Electron Donor IV. Primary Electron Acceptor V. Concluding Remarks VI. Appendix References Chapter 6 Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity I. Introduction II. Intermediates of Oxygen Reduction III. Superoxide Dismutases IV. Bacterial Superoxide Dismutases V. The Mitochondrial Superoxide Dismutase VI. The Biological Significance of Superoxide Dismutase VII. The Catalases and Peroxidases VIII. Summary References Subject Index
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- © Academic Press 1976
- 28th January 1976
- Academic Press
- eBook ISBN: