Free Radicals in Biology V1

Free Radicals in Biology V1

1st Edition - January 28, 1976

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  • Editor: William Pryor
  • eBook ISBN: 9780323156820

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Free Radicals in Biology, Volume 1, provides an introduction to some of the basic concepts of free radical biology. The book emerged from the President's Symposium of the American Society for Experimental Pathology held in Atlantic City in April 1970. The book's opening chapter introduces a mechanistic view of free radical reactions using examples from biological systems. This is followed by a discussion of autoxidative damage to lipids in membranes. Some of the special chemistry of lipid oxidation are presented, and a number of novel ideas are suggested. The third chapter deals with the uses of electron-spin resonance in biology. Spin labeling is also discussed, which is one of the most useful methods of probing the chemical and physical environment of molecules in cells. The remaining chapters cover free radicals which occur in photosynthesis and the importance of the enzyme, superoxide dismutase. The study of the occurrence and reactions of this enzyme provides an important and extensive body of data clearly pointing to the significance of free radicals in cellular chemistry.

Table of Contents

  • List of Contributors

    General Preface


    Contents of Volume II

    Chapter 1 The Role of Free Radical Reactions in Biological Systems

    I. Introduction

    II. The Nature of Free Radicals

    III. Possible Mechanisms for the Initiation of Radical Reactions in Vivo

    IV. Termination Reactions

    V. Propagation Reactions

    VI. One-Electron versus Two-Electron Transfers


    Chapter 2 Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

    I. Formation of Free Radicals in Lipids

    II. Formation of Free Radicals in Lipid Membranes in Vitro

    III. Formation of Free Radicals in Lipid Membranes in Vivo


    Chapter 3 Applications of Electron Spin Resonance in Biology

    I. Introduction

    II. A Brief Description of esr as Applied to Free Radicals

    III. Some Additional Experimental Considerations

    IV. A Few Worked Examples of Biological Free Radicals or Their Reactions Elucidated by esr


    Chapter 4 Spin Labeling

    I. Introduction

    II. Essentials of the Method

    III. A Look at General Biological Applications

    IV. Conclusion


    Chapter 5 Free Radicals in Photosynthesis

    I. Introduction

    II. Bacterial Photosynthesis

    III. Primary Electron Donor

    IV. Primary Electron Acceptor

    V. Concluding Remarks

    VI. Appendix


    Chapter 6 Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

    I. Introduction

    II. Intermediates of Oxygen Reduction

    III. Superoxide Dismutases

    IV. Bacterial Superoxide Dismutases

    V. The Mitochondrial Superoxide Dismutase

    VI. The Biological Significance of Superoxide Dismutase

    VII. The Catalases and Peroxidases

    VIII. Summary


    Subject Index

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 28, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323156820

About the Editor

William Pryor

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