Foundations of Mathematical Biology - 1st Edition - ISBN: 9780125972031, 9781483271859

Foundations of Mathematical Biology

1st Edition

Supercellular Systems

Editors: Robert Rosen
eBook ISBN: 9781483271859
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 430
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Foundations of Mathematical Biology, Volume III, is devoted to the treatment of behavior of whole organisms and groups of organisms. The viewpoint taken throughout the book is a holistic, phenomenological one. That is, the integrated behavior of these organisms and groups of organisms is not, in general, referred back to specific structural properties of interacting subunits (as in a reductionist scheme), but is rather treated on its own terms without invoking the properties of lower levels of organization. The book begins with an overview of organization and control in physiological systems, with emphasis on the mathematical techniques involved in more detailed investigations of specific physiological mechanisms. Separate chapters cover the cardiovascular system, with particular reference to blood flow; gross problems of organic form; a relational overview of physics, biology, and sociology; the automata theory in the context of the central nervous system; and populations of interacting organisms. The final chapter discusses the material presented in the entire work, some of its philosophical presuppositions and implications, and the possibility of constructing a unified theory of mathematical biology.

Table of Contents

List of Contributors


Contents of Other Volumes

Chapter 1 Physiological Regulation and Control

I. Introduction

II. Mathematical Formulation of Systems

A. Some General Definitions

B. Assumptions

C. Description of Linear Systems

D. State Vector and State Equations

E. The Transfer Function and Its Properties

F. Vector Representation of Transfer Functions

G. Example: Electrical Phenomena across Excitable Membranes

III. Control Theory

A. Structure and Dynamics of Control Systems

B. Structure of Physiological Control

IV. Stability and Oscillations

A. Stability

B. Oscillations and Stability in Physiological Systems

V. Optimization

A. An Evolutionary Basis for Design and Operating Optimization

B. Hierarchical Aspects

C. Performance Indices, Cost Functions

D. Analytical Trade-off and Optimality Conditions

E. The Respiratory-Cardiovascular System


Chapter 2A Mathematical Aspects of Some Cardiovascular Phenomena

I. Introduction and Scope

II. Linear Case

III. Some Applications of the Linear Case: A Two-Chamber Theory

IV. Nonlinear Case

V. Applications of the Nonlinear Theory

VI. Volume Elasticity and the Elasticity of the Blood Vessel Wall:

Propagation of Pulse Waves


Chapter 2B The Principle of Adequate Design

I. Models and General Principles in Biology

II. Quantitative Description of a Form of an Organism

III. Form of Plants

IV. An Example of the Application to the External Shape of a Quadruped

V. Application to the Size of the Aorta

VI. Overall Design of the Circulatory System: Peripheral Resistance

VII. The Overall Design of the Cardiovascular System and the Evaluation

of Its Basic Parameters


Chapter 2C A Unified Approach to Physics, Biology, and Sociology

Chapter 3 Automata Theory in the Context of Theoretical Neurophysiology

I. The Concept of State

II. Finite-State Models of Neural Nets

III. Complexity Theory for Pattern Recognition Networks

IV. An Aside: Gödel's Incompleteness Theorem

V. From External to Internal Descriptions

VI. The Correction of Errors in Communication and Computation

A. Reliable Brains from Unreliable Neurons

B. Von Neumann's Multiplexing Scheme

C. Shannon's Communication Theory

D. Communication Theory and Automata

E. The Cowan-Winograd Theory of Reliable Automata


Chapter 4 The Deterministic Theory of Population Dynamics

I. Introduction

II. The Dynamics of an Isolated Species

A. Malthus' Equation

B. The Pearl-Verhulst Equation

C. A General Logistics Growth Rate Function

III. The Modes of Interaction between Two Species

A. Competition and Volterra's Competitive Exclusion Principle: Two

Species Competing for a Common Ecological Niche

B. Two Species Living in a Predator-Prey Relationship

C. Symbiosis

D. Parasitism

E. A General Qualitative Theory for the Interactions between Two


IV. The Interactions between Three or More Species

A. Competition Involving Several Species

B. Predation Involving Several Species

V. Incorporation of "Historical Actions"

A. The System Equations for Predation

B. Law of Conservation of the Means and Law of Perturbation of the

Means for "Historical Actions"

VI. Epilogue


Chapter 5 Is There a Unified Mathematical Biology?

Author Index

Subject Index, Volume I

Subject Index, Volume II

Subject Index, Volume III


No. of pages:
© Academic Press 1973
Academic Press
eBook ISBN:

About the Editor

Robert Rosen