Table of Contents

Preface 1. The Beginning of Computational Genomics 2. Finding Sequence Similarities 3. Homology: Can We Get It Right? 4. Getting Ready for the Era of Comparative Genomics: The Importance of Viruses 5. The First Fact of Comparative Genomics: Protein Sequences are Remarkably Resilient in Evolution 6. The Second Fact of Comparative Genomics: Functional Convergence at the Molecular Level 7. Prediction of Function and Reconstruction of Metabolism from Genomic Data: Homology-Based Approaches 8. Prediction of Function and Reconstruction of Metabolism: Post-Homology Approaches 9. Structural Genomics:What Does It Tell Us about Life? 10. How Many Protein Families are There? 11. Phylogenetic Inference and the Era of Complete Genomes 12. Two Stories about Evolution 13. Minimal and Ancestral Genomes 14. Comparative Genomics and Systems Biology References Index


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© 2007
Academic Press
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About the author

Arcady Mushegian

Arcady R. Mushegian is Director of Bioinformatics at Stowers Institute for Medical Research in Kansas City and Professor of Microbiology at Kansas University Medical Center. He was born in Moscow, USSR, and graduated from Moscow State University.

Affiliations and Expertise

Stowers Institute for Medical Research and Kansas University Medical Center, Kansas City, Missouri, U.S.A.