Foundations of Comparative Genomics

1st Edition

Authors: Arcady Mushegian
Print ISBN: 9780120887941
eBook ISBN: 9780080546094
Imprint: Academic Press
Published Date: 30th March 2007
Page Count: 280
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Table of Contents


  1. The Beginning of Computational Genomics
  2. Finding Sequence Similarities
  3. Homology: Can We Get It Right?
  4. Getting Ready for the Era of Comparative Genomics: The Importance of Viruses
  5. The First Fact of Comparative Genomics: Protein Sequences are Remarkably Resilient in Evolution
  6. The Second Fact of Comparative Genomics: Functional Convergence at the Molecular Level
  7. Prediction of Function and Reconstruction of Metabolism from Genomic Data: Homology-Based Approaches
  8. Prediction of Function and Reconstruction of Metabolism: Post-Homology Approaches
  9. Structural Genomics:What Does It Tell Us about Life?
  10. How Many Protein Families are There?
  11. Phylogenetic Inference and the Era of Complete Genomes
  12. Two Stories about Evolution
  13. Minimal and Ancestral Genomes
  14. Comparative Genomics and Systems Biology References Index


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© Academic Press 2007
Academic Press
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About the Author

Arcady Mushegian

Arcady R. Mushegian is Director of Bioinformatics at Stowers Institute for Medical Research in Kansas City and Professor of Microbiology at Kansas University Medical Center. He was born in Moscow, USSR, and graduated from Moscow State University.

Affiliations and Expertise

Stowers Institute for Medical Research and Kansas University Medical Center, Kansas City, Missouri, U.S.A.