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Foundations of Colorectal Cancer - 1st Edition - ISBN: 9780323900553

Foundations of Colorectal Cancer

1st Edition

Editor: Alejandro Sierra
Paperback ISBN: 9780323900553
Imprint: Academic Press
Published Date: 1st November 2021
Page Count: 800
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Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow. 

The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues.

Key Features

  • Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition
  • Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject
  • Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data
  • Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers


Cancer researchers; oncologists; clinicians; practitioners. All professionals involved in treatment of colorectal cancer patients

Table of Contents

SECTION I. Clinical manifestations and disease detection
1. Primary prevention of colorectal cancer
2. Population-based universal screening for CRC. Secondary prevention
3. The role of primary care in early referral of CRC patients
4. Fast patient referral with suspected CRC

SECTION II. Diagnosis and staging
5. Endoscopic diagnosis of colorectal cancer
6. Colon endoscopic capsule
7. Endoscopic ultrasound in colorectal cancer
8. Virtual colonoscopy. Colo-CT
9. Colorectal cancer staging: ultrasound and multislice CT
10. Applications of [18F] FDG PET and PET-CT in colorectal carcinoma
11. MRI of rectal adenocarcinoma
12. Molecular pathology of colorectal carcinoma
13. Anatomopathologic diagnosis of CRC
14. Colonoscopy. Technique and quality factors
15. Endoscopic diagnosis of preneoplastic and neoplastic lesions

SECTION III. Treatment
16. Multidisciplinary committee for a comprehensive approach to colorectal cancer patients
Endoscopic treatment
17. Endoscopic treatment of preneoplastic or early lesions
18. Endoscopic monitoring
19. Advanced endoscopy in CRC. Colorectal prostheses
Surgical treatment
20.  Surgical Emergency in RCC
21.  Experimental surgery in RCC
22. Colon and rectal cancer surgery
23. Treatment of liver metastases in colorectal cancer
Pharmacological treatment and radiotherapy
24. Chemotherapy in advanced and metastatic disease
25. Adjuvant chemotherapy in colorectal cancer
26. Oral administration of cytostatic drugs for colorectal cancer treatment
27. Complementary and intraoperative neoadjuvant chemotherapy in rectal cancer
28. Immunology and immunotherapy in colorectal cancer
Anesthetic and postoperative management
29. Multimodal rehabilitation: optimizing pre and intraoperative surgery in colorectal cancer
30. Postoperative management: Complications and critical care unit management
31. Pain units: Symptom control

SECTION IV. Molecular and biological mechanisms of CRC
32. The role of intestinal microbiota in the colorectal cancer
33. Genetic susceptibility to colorectal cancer and chemotherapy response
34. Stem cells and colon cancer
35. Signaling pathways in colon cancer
36. Colorrectal Cancer a Darwinian the Celular Inmune-Selection Model
37. Epithelial-mesenchymal transition and colorectal cancer

SECTION V. New diagnostic methods
38 Biomarkers
39. Bioinformatic tools for research in colorectal cancer
40. Omic-based Biomarkers for Colorectal Cancer

SECTION VI. Biobanks
41. Regulations regarding the use of human biological samples for research
42. The role of biobanks in the study of colorectal carcinoma

SECTION VII. Epidemiological studies in CRC
43. Incidence and mortality of colorectal cancer : an international and regional vision
44. Prognosis and follow-up of colorectal cancer patients. Role of diagnostic and therapeutic delay

SECTION VIII. Hereditary colorectal cancer
45. Hereditary nonpolyposis colorectal cancer
46. Hereditary polyposis colorectal cancer

SECTION IX. Addressing the consequences of CRC
47. Addressing and psychologically controlling the disease
48. Ostomy care
49. Fecal incontinence and colorectal cancer
50. Ethical issues in CRC diagnosis and treatment
51. Sexuality in Ostomized Digestive Patients (Sexual Dysfunction in the Ostomized Patient)


No. of pages:
© Academic Press 2021
1st November 2021
Academic Press
Paperback ISBN:

About the Editor

Alejandro Sierra

Prof. Dr. Alejandro Pazos Sierra MD, Ms, PhD was graduated in Medicine at the University of Santiago de Compostela (USC) in 1987 and received his Master in Knowledge Engineering at the University Polytechnic of Madrid (UPM) in 1989 and his Doctor Degree in Computer Science, at the UPM in 1990. In 1996, he also received his doctorate in Medicine and Surgery from the Complutense University of Madrid (UCM). Since 1989, he has worked with several research groups from institutions such as Technological Institute of Georgia, the Harvard Medical School, Stanford University, and University of Aveiro (Portugal). Since 1999, he is Full Professor in the Faculty of Computer Science at the University of A Coruña. In 1995, he founded the Laboratory of Artificial Neural Networks and Adaptive Systems (RNASA-IMEDIR). From foundation, twelve years ago, he is also the coordinator of the Galician Research Network of Colorectal Cancer (REGICC)

Affiliations and Expertise

Full Professor, Faculty of Computer Science, University of A Coruna; Coordinator, Galician Research Network of Colorectal Cancer (REGICC), A Coruna, Galicia, Spain

Ratings and Reviews