Forkhead FOXO Transcription Factors in Development and Disease

Forkhead FOXO Transcription Factors in Development and Disease

1st Edition - February 6, 2018

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  • Editor: Saghi Ghaffari
  • Hardcover ISBN: 9780128042533
  • eBook ISBN: 9780128043363

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Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics. This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism.

Key Features

  • Provides the authority and expertise of leading contributors
  • Includes sections on the regulation of FOXO factors and stem cells
  • Presents a unique view of this highly evolutionary family of transcription factors


Researchers in cell, molecular, developmental and evolutionary biology and in genetics

Table of Contents

  • 1. DAF-16: FOXO in the Context of C. elegans
    Heidi A. Tissenbaum
    2. Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm
    Raymond Liang and Saghi Ghaffari
    3. FOXOs Maintaining the Equilibrium for Better or for Worse
    Sabina van Doeselaar and Boudewijn M.T. Burgering
    4. FOXO in Neural Cells and Diseases of the Nervous System
    Evan E. Santo and Jihye Paik
    5. Regulation of Hepatic Glucose Metabolism by FOXO Proteins, an Integrated Approach
    Terry G. Unterman
    6. The Role of FOXOs in Bone Health and Disease
    Ha-Neui Kim, Srividhya Iyer, Rebecca Ring and Maria Almeida
    7. Regulation of FOXO Factors in Mammalian Cells
    Abigail K. Brown and Ashley E. Webb
    8. FOXO3 and Exceptional Longevity: Insights From Hydra to Humans
    Philip M.C. Davy, Richard C. Allsopp, Timothy A. Donlon, Brian J. Morris, D. Craig Willcox and Bradley J. Willcox

Product details

  • No. of pages: 224
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: February 6, 2018
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128042533
  • eBook ISBN: 9780128043363

About the Serial Volume Editor

Saghi Ghaffari

Dr. Saghi Ghaffari is a Physician Scientist and Professor at Icahn School of Medicine at Mount Sinai (ISMMS). Her research is on mechanisms implicated in blood production and disorders of blood. Her work has been partly focused on FOXO transcription factors and their contributions to the healthy blood formation. She has been trained in Medicine in Paris, France, obtained her PhD in Vancouver, Canada and further training at the Whitehead Institute for Biomedical Research at MIT in Cambridge, USA. She has been at the ISMMS since 2003.

Affiliations and Expertise

Icahn Medical Institute, NY, USA

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