Folic Acid and Folates
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
Key Features
- Includes color illustrations
- Available on ScienceDirect
- Longest running series published by Academic Press
- Contributions by leading international authorities
Readership
Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.
Table of Contents
- 1. Folate-Mediated One-Carbon Metabolism
Jennifer T. Fox and Patrick J. Stover
2. Mathematical Models of Folate-Mediated One-Carbon Metabolism
H. Frederik Nijhout, Michael C. Reed and C.M. Ulrich
3. Folate Deprivation, the Methionine Cycle and Alzheimer¡¦s Disease
Flaubert Tchantchou and Thomas B. Shea
4. Benefits and Risks of Folic Acid Supplementation
Young-In Kim
5. Molecular Mechanisms of Adaptation to Folate Deficiency
Ilan Ifergan and Yehuda G. Assaraf
6. Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient Transporter
Larry H. Matherly and Zhanjun Hou
7. Renal Conservation of Folates: Role of Folate Transport Proteins
Vijaya L. Damaraju, Carol E. Cass and Michael B. Sawyer
8. Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory Disease
Christopher P. Leamon and Ann L. Jackman
9. Folate Receptor Expression in Pituitary Adenomas: Cellular and Molecular Analysis
Chheng-Orn Evans, Congjun Yao, David Leborde and Nelson M. Oyesiku
10. Regulation of Human Dihydrofolate Reductase Activity and Expression
Emine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, Yi-Ching Hsieh
11. Catalysis of Methyl Group Transfers Involving Tetrahydrofolate and B12
Stephen W. Ragsdale
12. Methyltetrahydrofolate in Folate-Binding Protein Glycine N-Methyltransferase
Zigmund Luka
13. Mechanism-Based Inhibitors of Folylpoly-ƒ×-glutamate Synthetase and ƒ×-Glutamyl Hydrolase: Control of Folylpoly-ƒ×-glutamate Homeostasis as a Drug Target
James K. Coward and John J. McGuire
14. Methylenetetrahydrofolate Reductase, Common Polymorphisms and Relation to Disease
Philip Thomas and Michael Fenech
15. Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase and Formyltetrahydrofolate Synthetases
Karen E. Christensen and Robert E. MacKenzie
16. The Structure and Mechanism of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase
Jeremy P. Derrick
Product details
- No. of pages: 480
- Language: English
- Copyright: © Academic Press 2008
- Published: October 1, 2008
- Imprint: Academic Press
- Hardcover ISBN: 9780123742322
About the Editor in Chief
Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.
Affiliations and Expertise
Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA