Folic Acid and Folates - 1st Edition - ISBN: 9780123742322, 9780080921266

Folic Acid and Folates, Volume 79

1st Edition

Editor-in-Chiefs: Gerald Litwack
Hardcover ISBN: 9780123742322
eBook ISBN: 9780080921266
Imprint: Academic Press
Published Date: 1st October 2008
Page Count: 480
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Institutional Access


Table of Contents

  1. Folate-Mediated One-Carbon Metabolism Jennifer T. Fox and Patrick J. Stover

  2. Mathematical Models of Folate-Mediated One-Carbon Metabolism H. Frederik Nijhout, Michael C. Reed and C.M. Ulrich

  3. Folate Deprivation, the Methionine Cycle and Alzheimer¡¦s Disease Flaubert Tchantchou and Thomas B. Shea

  4. Benefits and Risks of Folic Acid Supplementation Young-In Kim

  5. Molecular Mechanisms of Adaptation to Folate Deficiency Ilan Ifergan and Yehuda G. Assaraf

  6. Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient Transporter Larry H. Matherly and Zhanjun Hou

  7. Renal Conservation of Folates: Role of Folate Transport Proteins Vijaya L. Damaraju, Carol E. Cass and Michael B. Sawyer

  8. Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory Disease Christopher P. Leamon and Ann L. Jackman

  9. Folate Receptor Expression in Pituitary Adenomas: Cellular and Molecular Analysis Chheng-Orn Evans, Congjun Yao, David Leborde and Nelson M. Oyesiku

  10. Regulation of Human Dihydrofolate Reductase Activity and Expression Emine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, Yi-Ching Hsieh

  11. Catalysis of Methyl Group Transfers Involving Tetrahydrofolate and B12 Stephen W. Ragsdale

  12. Methyltetrahydrofolate in Folate-Binding Protein Glycine N-Methyltransferase Zigmund Luka

  13. Mechanism-Based Inhibitors of Folylpoly-ƒ×-glutamate Synthetase and ƒ×-Glutamyl Hydrolase: Control of Folylpoly-ƒ×-glutamate Homeostasis as a Drug Target James K. Coward and John J. McGuire

  14. Methylenetetrahydrofolate Reductase, Common Polymorphisms and Relation to Disease Philip Thomas and Michael Fenech

  15. Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase and Formyltetrahydrofolate Synthetases Karen E. Christensen and Robert E. MacKenzie

  16. The Structure and Mechanism of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase Jeremy P. Derrick


Description

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Key Features

Includes color illustrations Available on ScienceDirect Longest running series published by Academic Press Contributions by leading international authorities

Readership

Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.


Details

No. of pages:
480
Language:
English
Copyright:
© Academic Press 2008
Published:
Imprint:
Academic Press
eBook ISBN:
9780080921266
Hardcover ISBN:
9780123742322

About the Editor-in-Chiefs

Gerald Litwack Editor-in-Chief

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA