Fluorine Chemistry V3

Fluorine Chemistry V3

1st Edition - January 1, 1963

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  • Editor: J.H. Simons
  • eBook ISBN: 9780323158954

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Fluorine Chemistry, Volume III: Biological Effects of Organic Fluorides focuses on the biological threats of fluorine-containing compounds. The book first looks at the toxicity of fluoroacetate. Acute human poisoning, chemical factors, cause of death, pharmacological properties, evidence of fluorocitrate, and sites of inhibition are discussed. The text notes the biological effects of phosphofluoridates. Toxicity of DFP and derivatives, DFP metabolism, studies on DFP32 metabolism, and enzymes hydrolyzing DFP are described. The book also looks at the effects of acute doses of fluorine-containing organic compounds. The effects of organic fluorine compounds on enzyme systems; metabolic effects of tyrosine analogs; local anesthetics; effects of organofluorine compounds on microorganisms; and miscellaneous pharmacological effects of organic fluorides are discussed. The text underscores the acute effects of organofluorine compounds in experimental animals. Tabulated representations that show the effects of fluorine-containing compounds on humans and animals are presented. The book is a valuable source of information for readers wanting to study the biological effects of fluorine-containing compounds.

Table of Contents

  • Preface



    Acute Human Poisoning

    Species Variations

    Occurrence in Nature

    Chemical Factors

    Cause of Death

    Pharmacological Properties

    Essential Biochemical Lesions

    Citrate Concentration Increase

    Nature of the Inhibitor

    Evidence for Fluorocitrate

    The Sites of Inhibition


    Condensing Enzyme

    Acetoacetate Formation

    Amine Acetylation

    Thiol Esters



    F-Sensitive System

    Pigeon Liver Preparation

    Other Sources

    Metabolic Mechanisms: Summary

    Structure-Toxicity Relations


    Toxicity of DFP and Derivatives

    DFP Metabolism

    Studies of DFP32 Metabolism

    Enzymes Hydrolyzing DFP (DFPases)

    Acute Effects of Organofluorine Compounds in Experimental Animals

    Plan of Review

    Inhalation Toxicity

    Effects of Acute Doses of Fluorine-Containing Organic Compounds

    Anesthetic Effects

    Local Anesthetics

    Mephenesin Analogs

    Sympathomimetic Amines

    Metabolic Effects of Tyrosine Analogs


    Effects of Organic Fluorine Compounds on Enzyme Systems

    Anti-Tumor Action

    Effects of Organofluorine Compounds on Microorganisms




    Miscellaneous Pharmacological Effects of Organic Fluorides

    Rodent Repellency

    Organic Fluorine Compounds Useful as Insecticides

    Chronic Experimental Intoxication



    Table I. Acute Fatal Intoxication Caused by Sodium Fluoroacetate

    Table II. Acute, Nonfatal Intoxications Caused by Sodium Fluoroacetate

    Table III. Lethal Doses of Sodium Fluoroacetate in Various Species

    Table IV. Mean Lethal Dose (LD50) of Sodium Fluoroacetate in Various Species

    Table V. Mean Lethal Dose (LD50) of Methyl Fluoroacetate in Various Species

    Table VI. Mean Lethal Dose (LD50) of Organic Compounds Containing the C-F Link

    Table VII. Metabolic Interference in Systems Utilizing Pyruvate and Acetate

    Table VIII. Increase in Citrate Concentration Due to FAc

    Table IX. Inhibition of Citrate Oxidation

    Table X. Citric Acid Content of Rat Tissues in Vivo following Injection of Fluoroacetate

    Table XI. The Toxicity of and Citrate Accumulation Caused by Representative Even and Odd ω-Fluoro Compounds Administered to Mice

    Table XII. Comparative Toxicities of DFP, Sarin, and Tabun in the Mouse

    Table XIII. Mean Lethal Dose (LD50) of Diisopropyl Phosphofluoridate in Various Species

    Table XIV. Mean Lethal Dose (LD50) of Organic Fluorophosphate Compounds

    Table XV. Hydrolysis of Diisopropyl Phosphofluoridate by Tissue Extracts

    Table XVI. Acute Doses of Fluorine-Containing Organic Compounds in Various Species

    Table XVII. Approximate Lethal Concentration of Fire Extinguisher Compounds in Order of Increasing Toxicity

    Table XVIII. Toxic Effects of Fluorocarbons by Inhalation

    Table XIX. Miscellaneous Effects of Fluorine-Containing Organic Compounds

    Table XX. Fluorine-Containing Organic Compounds Tested for Anesthetic Properties

    Table XXI. Glucocorticoid and Mineralocorticoid Activities of Fluorocorticosteroids

    Table XXII. Effects of Fluorine-Containing Compounds on Enzyme Systems

    Table XXIII. Fluorine-Containing Organic Compounds Tested as Tumor Inhibitors in the Mouse

    Table XXIV. Effects of Fluorine-Containing Organic Compounds upon Microorganisms

    Table XXV. Fluorine-Containing Compounds Tested as Antimalarial Agents

    Table XXVI. Additional Fluorine-Containing Compounds Tested as Antimalarials

    Table XXVII. Effects of Fluorine-Containing Organic Compounds upon Fungi

    Table XXVIII. Breaking Strength of Cotton Thread Treated with Fungicides and Exposed 14 Days to Mycothecium verrucario

    Table XXIX. Repellency Index for Rats of Fluorine-Containing Organic Compounds

    Table XXX. Activity of Difluorodiphenyltrichloroethane (DFDT) against Pests

    Table XXXI. Activity of Miscellaneous Fluorine-Containing Organic Compounds against Pests

    Table XXXII. Fluorine-Containing Organic Compounds Tested as Plant Growth Regulators

    Table XXXIII. Experimental Chronic Intoxication in the Rat Produced by Fluorine-Containing Organic Compounds

    Table XXXIV. Organ Systems of the Rat Affected in Chronic Intoxication Produced by Fluorine-Containing Organic Compounds


    Bibliographical Supplement (1959-1961)

    Subject Index

Product details

  • No. of pages: 252
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9780323158954

About the Editor

J.H. Simons

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