Fluorine and Health - 1st Edition - ISBN: 9780444530868, 9780080558110

Fluorine and Health

1st Edition

Molecular Imaging, Biomedical Materials and Pharmaceuticals

Editors: Alain Tressaud Gunter Haufe
eBook ISBN: 9780080558110
Hardcover ISBN: 9780444530868
Imprint: Elsevier Science
Published Date: 24th April 2008
Page Count: 816
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Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms

Key Features

  • New approach of topics involving chemistry, biology and medicinal techniques
  • Transdisciplinar papers on fluoride products
  • Importance of fluoride products in health
  • Updated data on specific topics


Researchers in industry Scientists in academia Medical doctors PhD students

Table of Contents


  1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission Tomography
    Frédéric Dollé, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne

  2. Application of 18F-PET Imaging for the Study of Alzheimer’s Disease
    Kjell Någren and Juha O. Rinne

  3. 18F-Labeled PET-Tracers for Cardiological Imaging
    Klaus Kopka, Stefan Wagner, Michael Schäfers, Andreas Faust, Otmar Schober, and Günter Haufe

  4. [18F]-Labeled PET and PET/CT Compounds in Oncology
    Ken Herrmann and Bernd Joachim Krause

  5. Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance
    Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. Mason


  1. Fluoride-Based Bioceramics
    Christian Rey, Christèle Combes, Christophe Drouet, and Hocine Sfihi

  2. Fluoride in Dentistry and Dental Restoratives
    John W. Nicholson and Beata Czarnecka

  3. Fluorinated Biomaterials for Cardiovascular Surgery
    Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin

  4. Fluorinated Molecules in Eye Surgery: Experimental and Clinical Benefit of a Heavy Silicone Oil Oxane Hd® (Mixture of Silicone Oil and RMN3 Fluorine Olefin) in the Treatment of Retinal Detachment
    I. Rico-Lattes, J. C. Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis

  5. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery
    Dirk-Henning Menz and Joachim H. Dresp

  6. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond


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© Elsevier Science 2008
Elsevier Science
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About the Editor

Alain Tressaud

Alain Tressaud

Alain Tressaud is Emeritus Research Director at ICMCB-CNRS, Bordeaux University. He is President of the European Academy of Science in Brussels and member of several European academies. He founded and chaired the French Network on Fluorine Chemistry, sponsored by CNRS, until 2008. He has received several awards, including the CEA Award of French Academy of Sciences (2008), the Fluorine Award of the American Chemical Society (2011), and the International Henri Moissan Prize (2013). His scientific interest covers various fields, including synthesis, physical chemical characterizations, applications in fluorine chemistry, solid state chemistry, and materials sciences. His work also deals with surface modification of materials and intercalation chemistry. Professor Tressaud’s scientific production includes more than 360 papers in international journals, 20 book chapter contributions, and 12 internationalized patents. He has also edited several books in his role as editor-in-chief of the series “Advances in Fluorine Science” (2006) and “Progress in Fluorine Science” (2016) with Elsevier.

Affiliations and Expertise

ICMCB-CNRS University of Bordeaux, Pessac Cedex, France

Gunter Haufe

Günter Haufe, Professor at Münster Univ., Germany is one of the top leading European scientists in the field of the synthesis of new active molecules in Bioorganics and to their applications in Medical Sciences. His researches are mainly devoted to the discovery of new and selective molecules, active against various illnesses, including cancer, heart arrhythmia, neurological diseases (more than 250 papers in peer-referred journals). He is Editor for Europe, Africa & Australia of the Journal of Fluorine Chemistry. He edited the book: “Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals”, Elsevier, Amsterdam (2008). He is Fellow of the European Academy of Sciences (Brussels).

Affiliations and Expertise

Organic Chemistry Institute, University of Münster, Germany

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