1st Edition - November 28, 1988

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  • Editor: Deane Mosher
  • eBook ISBN: 9780323148245

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Fibronectin presents the studies made on the physiological and pathophysiological roles of fibronectin. The book presents chapters that discuss the primary structure of fibronectin and its mRNA; the physicochemical properties of fibronectin and fibronectin fragments; the fibronectin-containing extracellular matrix; the relationship of fibronectin and fibronectin-containing matrix to embryogenesis, wound healing, and the biology of cancer cells; the roles of fibronectin in platelet aggregation, attachment of microorganisms, pathogenesis of kidney diseases, arthritis, and lung fibrosis; and the production of purified concentrates of fibronectin suitable for use in patients. The book will be of much interest to biologists, biochemists, pharmacologists, and medical practitioners and researchers.

Table of Contents

  • Contributors


    Primary Structure of Fibronectin

    I. Introduction

    II. Primary Structure

    III. Genomic Structure


    Note Added in Proof

    Physical Properties of Fibronectin

    I. Introduction

    II. Electron Microscopy

    III. Shape in Solution

    IV. Spectroscopic Properties

    V. Conformational Stability

    VI. Correlation Between Conformational and Sequence Information


    Fibronectin Domains and Receptors

    I. Introduction

    II. Functional Activities of Fibronectin

    III. Characterization of Domains in the Intact Molecule

    IV. Cell Interaction Sites

    V. Collagen-Binding Site

    VI. Fibrin-Binding Domains

    VII. Glycosaminoglycan-Binding Domains

    VIII. Other Domains

    IX. Fibronectin Receptor

    X. Future Prospects


    Fibronectin and the Pericellular Matrix

    I. Introduction

    II. Pericellular Fibronectin Fibers

    III. Association of the Matrix with the Cell Surface

    IV. Isolation and Composition of the Pericellular Matrix

    V. Cellular Effects of Isolated Matrices

    VI. Proteoglycans in the Pericellular Fibronectin-Containing Matrix


    Fibronectin-Cytoskeleton Relationships

    I. Introduction

    II. The Fibronexus in Vitro

    III. In Vivo Studies of Fibronectin-Cytoskeleton Associations

    IV. Summary and Future Directions


    The Assembly of the Fibronectin Matrix in Cultured Human Fibroblast Cells

    I. Introduction

    II. Kinetics of Matrix Assembly

    III. Identification of a Cell-Binding Site for Matrix Assembly on the Fibronectin Molecule

    IV. Mechanism of Disulfide-Bonded Multimer Formation

    V. Mechanism for Matrix Assembly

    VI. Cell Surface Receptors for Fibronectin


    Roles of Fibronectins in Embryogenesis

    I. Introduction

    II. Possible Involvement of Fibronectins in Primary Processes

    III. Requirement for Fibronectins During Embryonic Cell Migration

    IV. Concluding Remarks


    Fibronectin in Wound Healing

    I. Introduction

    II. Outline of Events in a Simple Incisional Skin Wound

    III. Provisional Matrix

    IV. Fibroblasts

    V. Epithelium

    VI. Blood Vessels

    VII. Macrophages

    VIII. Other Cells, Other Wounds

    IX. Evolutionary Aspects of Wound Healing

    X. Defective Wound Healing

    XI. Control Mechanisms

    XII. Can Exogenous Fibronectin Accelerate Wound Healing?


    Fibronectin and Malignant Transformation

    I. Introduction

    II. Fibronectin and Transformation of Fibroblastic Cells

    III. Fibronectin and Malignant Epithelial Cells

    IV. Fibronectin Production and Tumor Cell Classification

    V. Fibronectin and Malignant Growth in Vivo

    VI. Fibronectin and Cell Anchorage in Transformation

    VII. Proteolysis of Fibronectin and Malignancy

    VIII. Focal Proteolysis

    IX. Concluding Remarks


    Fibronectin: A Contender in Platelet Adhesive Functions

    I. Introduction

    II. Role of Fibronectin in Platelet Function

    III. Localization of Fibronectin

    IV. Binding of Fibronectin to Platelet(s)

    V. Concluding Remarks


    Interactions of Pathogenic Microorganisms with Fibronectin

    I. Introduction

    II. Fibronectin-Binding Microorganisms

    III. Binding Sites in Fibronectin for Different Microorganisms

    IV. Microbial Fibronectin Receptors

    V. Regulation of Fibronectin Receptor Expression

    VI. Implications of Microbial Fibronectin Binding

    VII. Microbial Binding of Other Matrix Components


    Fibronectin and the Kidney

    I. Introduction

    II. Localization of Fibronectin

    III. Role of Fibronectin in Differentiation of the Nephron

    IV. Role of Fibronectin in Kidney Culture

    V. Role of Fibronectin in Kidney Pathology

    VI. Pathology of Animals Experimentally Immunized with Fibronectin

    VII. Summary

    VIII. Future Directions


    Role of Fibronectin in Rheumatic Diseases

    I. Introduction

    II. Fibronectin in Rheumatoid Arthritis (RA)

    III. Effects of Fibronectin on the Function of Cell Types Found in Inflammatory Synovium

    IV. Fibronectin and Cartilage

    V. Interactions among Fibronectin and Other Macromolecules in Synovial Fluid

    VI. Other Rheumatic Diseases

    VII. Conclusion


    Fibronectin in the Lung

    I. Introduction

    II. Localization of Fibronectin in the Lung

    III. Fibronectin Synthesis by Lung Cells

    IV. Fibronectin in the Diseased Lung

    V. Potential Roles of Fibronectin in the Lung


    Kinetics of Plasma Fibronectin: Relationship to Phagocytic Function and Lung Vascular Integrity

    I. Introduction

    II. The Reticuloendothelial Systemic Host Defense System

    III. Reticuloendothelial Particle Clearance and Plasma Fibronectin Depletion

    IV. Reticuloendothelial Function and Resistance to Trauma

    V. Opsonic α2 Surface-Binding (SB) Glycoprotein and Plasma Fibronectin

    VI. Cell Surface and Tissue Fibronectin

    VII. Domain Organization of Fibronectin (Structure-Function Relationship)

    VIII. Pulmonary Failure During Sepsis Posttrauma

    IX. Multiple Organ Failure and Plasma Fibronectin Deficiency

    X. Reversal of Plasma Fibronectin Deficiency in Patients with Cryoprecipitate or Purified Human Plasma Fibronectin

    XI. Plasma Fibronectin and Lung Vascular Permeability with Sepsis

    XII. Kinetics of Plasma Fibronectin

    XIII. Conclusions

    XIV. Forecast for Future Developments


    Preparation of Fibronectin for Therapeutic Administration

    I. General Remarks

    II. Assay of Fibronectin Opsonic Activity in Vitro

    III. Purification

    IV. Characterization of Purified Fibronectin

    V Concluding Remarks



Product details

  • No. of pages: 492
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: November 28, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9780323148245

About the Editor

Deane Mosher

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