Fetal Endocrinology and Metabolism

Fetal Endocrinology and Metabolism

Current Topics in Experimental Endocrinology, Vol. 5

1st Edition - April 28, 1983

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  • Editors: L Martini, V. H. T. James
  • eBook ISBN: 9781483217376

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Current Topics in Experimental Endocrinology, Volume 5: Fetal Endocrinology and Metabolism covers various aspects of fetal endocrinology. The book discusses studies of the hypothalamic-pituitary unit which emphasize the unique aspects of the fetal endocrine system; in vitro fertilization; and factors controlling placental endocrine function in domestic animals. The text also describes the role and kinetics of thyroid in fetal development; the placental transfer of carbohydrates; and fetal hormones and carbohydrate utilization. The regulation of partition of protein during pregnancy; the mineral needs of the fetus; and the fetal metabolism of cortisol are also considered. The book further tackles normal and abnormal sexual differentiation and the metabolic errors of adrenal steroidogenesis. Physiologists, endocrinologists, obstetricians, gynecologists, and students taking related courses will find the book invaluable.

Table of Contents

  • Contributors


    The Fetal Neuroendocrine Axis

    I. Introduction

    II. The Development of the Hypothalamus and Adenohypophysis

    III. The Secretion and Function of Fetal Adenohypophyseal Hormones

    IV. Autonomy of the Fetal Neuroendocrine Unit


    In Vitro Fertilization

    I. The Natural Ovulatory Cycle and IVF

    II. The Stimulated or Controlled Ovulatory Cycle

    III. Maturation of the Oocyte

    IV. The Technique of in Vitro Fertilization

    V. The Use of IVF in Male and Idiopathic Infertility


    Factors Controlling Placental Endocrine Function in Domestic Animals

    I. Introduction

    II. Control of Placental Steroid Secretion by Fetal Cortisol in Domestic Animals

    III. Control of Secretion of Placental Lactogens

    IV. Effects of β-Catecholaminergic Drugs on the Placenta

    V. Conclusions


    The Fetal Thyroid

    I. Introduction

    II. The Choice of Preparation

    III. The Morphological and Secretory Development of the Gland

    IV. The Placental Barrier

    V. The Role of the Thyroid in Fetal Development

    VI. Fetal Thyroid Hormone Kinetics

    VII. Perinatal Thyroid Hormone Concentrations

    VIII. Conclusion


    Carbohydrate Metabolism

    I. Introduction

    II. Maternal Hormonal and Metabolic Adaptations

    III. Early Embryonic Development

    IV. Placental Transfer of Carbohydrates

    V. Fetal Hormones and Carbohydrate Utilization

    VI. Fetal Metabolic Pathways

    VII. Summary


    Regulation of Partition of Protein during Pregnancy

    I. Introduction

    II. Placental Protein

    III. Fetal Protein

    IV. Free Amino Acid Pools

    V. Maternal Protein


    Mineral Needs of the Fetus

    I. Introduction

    II. Calcium, Phosphate, Magnesium

    III. Parathyroid Hormone (PTH)

    IV. Vitamin D

    V. Calcitonin

    VI. Hormone Interrelations

    VII. Conclusion


    Fetal Metabolism of Cortisol

    I. Introduction

    II. Circulating Levels of Cortisol in the Fetus

    III. Sources of Cortisol in the Fetal Circulation

    IV. Fate of Fetal Cortisol

    V. Significance of Cortisol in the Fetus

    VI. Summary


    Sexual Differentiation: Normal and Abnormal

    I. Embryology of Sexual Differentiation

    II. Determinants of Phenotypic Differentiation

    III. Genetic Control of Sexual Differentiation

    IV. Sexual Differentiation of the Brain

    V. Male Pseudohermaphroditism

    VI. XX Males and True Hermaphroditism

    VII. Female Pseudohermaphroditism


    Metabolic Errors of Adrenal Steroidogenesis

    I. Introduction

    II. Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones

    III. Fetal Sexual Development

    IV. Enzyme Defects in Congenital Adrenal Hyperplasia

    V. The Zona Fasciculata and Zona Glomerulosa as Separate Glands

    VI. Treatment of Congenital Adrenal Hyperplasia

    VII. Genetics of Congenital Adrenal Hyperplasia

    VIII. Prenatal Diagnosis of Congenital Adrenal Hyperplasia

    IX. Summary



Product details

  • No. of pages: 378
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: April 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483217376

About the Editors

L Martini

V. H. T. James

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