Fetal and Neonatal Physiology, 2-Volume Set - 5th Edition - ISBN: 9780323352147, 9780323352321

Fetal and Neonatal Physiology, 2-Volume Set

5th Edition

Authors: Richard Polin Steven Abman David Rowitch William Benitz
Hardcover ISBN: 9780323352147
eBook ISBN: 9780323352321
eBook ISBN: 9780323352338
Imprint: Elsevier
Published Date: 1st July 2016
Page Count: 1928

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Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.

The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.

Key Features

    • Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
    • Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
    • Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

    Table of Contents

    Section I - Genetics and Embryology

    1. Basic Genetic Principles
    2. Prenatal Diagnosis
    3. Basic Embryology
    4. Regulation of Embryogenesis
    5. The Extracellular Matrix in Development
    6. Stem Cell Biology
    7. Apoptotic Cell Death
    8. Angiogenesis
    9. Epigenetics
    10. Section II - Placenta and Intrauterine Environment

    11. Placental Development
    12. Regulation of the Placental Circulation
    13. Mechanisms of Transfer Across the Human Placenta
    14. Endocrine and Paracrine Function of the Human Placenta
    15. Fetal and Maternal Responses to Intrauterine Infection
    16. Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
    17. Physiologic Effects of Multiple Pregnancy on Mother and Fetus
    18. Placental function in intrauterine growth restriction
    19. Section III - Developmental Pharmacology and Pharmacokinetics

    20. Basic Pharmacologic Principles
    21. Principles of Pharmacokinetics
    22. Physicochemical and Structural Properties Regulating Placental Drug Transfer
    23. Pharmacogenetics
    24. Drug Distribution in Fetal Life
    25. Drug Transfer During Breastfeeding
    26. Section IV - Intrauterine and Postnatal Growth

    27. Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
    28. Endocrine Factors Affecting Neonatal Growth
    29. Human Milk Composition and Function in the Infant
    30. Physiology of Lactation
    31. Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

    32. Fetal and Neonatal Iron Metabolism
    33. Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
    34. Zinc in the Fetus and Neonate
    35. Vitamin A Metabolism in the Fetus and Neonate
    36. Vitamin E Metabolism in the Fetus and Newborn Infant
    37. Vitamin K Metabolism in the Fetus and Neonate
    38. Section VI - Lipid Metabolism

    39. Maternal-Fetal Transfer of Lipid Metabolites
    40. Brown Adipose Tissue: Development and Function
    41. Lipids as an Energy Source for the Premature and Full-Term Neonate
    42. Ketone Body Production and Metabolism in the Fetus and Neonate
    43. Long-Chain Fatty Acids in the Developing Retina and Brain
    44. Section VII - Carbohydrate Metabolism

    45. Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
    46. Carbohydrate Metabolism During Pregnancy
    47. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
    48. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
    49. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
    50. Section VIII - Protein Metabolism

    51. General Concepts of Protein Metabolism
    52. Fetal Requirements and Placental Transfer of Nitrogenous Compounds
    53. Section IX - Thermoregulation

    54. Temperature Control in Newborn Infants
    55. Responses of the Fetus and Neonate to Hypothermia
    56. Section X - Skin

    57. Structure and Development of Skin and Cutaneous Appendages
    58. Physiologic Development of the Skin
    59. Section XI - Fetal and Neonatal Cardiovascular Physiology

    60. Cardiovascular Development
    61. Developmental Electrophysiology in the Fetus and Neonate
    62. Developmental Biology of the Pulmonary Vasculature
    63. Development of the Gastrointestinal Circulation in the Fetus and Newborn
    64. Physiology of Congenital Heart Disease in the Neonate
    65. Neural Regulation of Blood Pressure During Fetal and Newborn Life
    66. Developmental Effects on Fetal Circulation
    67. Mechanisms Regulating Closure of the Ductus Arteriosus
    68. Umbilical Circulation
    69. Fetal and Placental Circulation During Labor
    70. Physiology of Resuscitation
    71. Section XII - The Lung

    72. Normal and Abnormal Structural Development of the Lung
    73. Regulation of Alveolarization
    74. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
    75. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
    76. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
    77. Upper Airway Structure: Function, Regulation, and Development
    78. Regulation of Lower Airway Function
    79. Functional Development of Respiratory Muscles
    80. Mechanics of Breathing
    81. Pulmonary Gas Exchange in the Developing Lung
    82. Oxygen Transport and Delivery
    83. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
    84. Basic Mechanisms of Oxygen Sensing and Response to Hypoxia
    85. Evaluation of Pulmonary Function in the Neonate
    86. Mechanisms of Neonatal Lung Injury
    87. Impaired Lung Growth After Injury in Premature Lung
    88. Antenatal Factors That Influence Postnatal Lung Development and Injury
    89. Regulation of Pulmonary Circulation
    90. Section XIII - Surfactant

    91. Historical Perspective
    92. Composition of Pulmonary Surfactant Lipids and Proteins
    93. Structure And Development of Alveolar Epithelial Cells
    94. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
    95. Hormonal Therapy for Prevention of Respiratory Distress Syndrome
    96. Surfactant Treatment
    97. Genetics and Physiology of Surfactant Protein Deficiencies
    98. Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate

    99. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
    100. Organogenesis of the Gastrointestinal Tract
    101. Development of the Enteric Nervous System
    102. Development of Gastric Secretory Function
    103. Development of Gastrointestinal Motility
    104. Development of the Exocrine Pancreas
    105. Digestive-Absorption Functions in Fetuses, Infants, and Children
    106. Development of the Intestinal Microbiome
    107. Section XV - Liver and Bilirubin Metabolism

    108. Organogenesis and Histologic Development of the Liver
    109. Bile Acid Metabolism During Development
    110. Neonatal Bilirubin Metabolism
    111. Hereditary Contribution to Neonatal Hyperbilirubinemia
    112. Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia
    113. Section XVI - The Kidney

    114. Embryogenesis and Anatomic Development of the Kidney
    115. Functional Development of the Kidney in Utero
    116. Development and Regulation of Renal Blood flow in the Neonate
    117. Development of the Renin-Angiotensin System
    118. Postnatal Development of Glomerular Filtration Rate in Neonates
    119. Renal Transport of Sodium During Early Development
    120. Potassium Homeostasis in the Fetus and Neonate
    121. Role of the Kidney in Calcium and Phosphorus Homeostasis
    122. Transport of Amino Acids in the Fetus and Neonate
    123. Developmental Aspects of Organic Acid Transport
    124. Concentration and Dilution of the Urine
    125. Development of Acidification Mechanisms in the Fetus and Neonate
    126. Response to Nephron Loss in Early Development
    127. Section XVII - Fluid and Electrolyte Metabolism

    128. Fluid Distribution in the Fetus and Neonate
    129. Regulation of Acid-Base Balance in the Fetus and Neonate
    130. Section XVIII - Developmental Hematopoiesis

    131. Developmental Biology of Stem Cells: From the Embryo to the Adult
    132. Developmental Granulocytopoiesis
    133. Developmental Erythropoiesis
    134. Developmental Megakaryocytopoiesis
    135. Section XIX - Hemostasis

    136. Developmental Hemostasis
    137. Platelet–Vessel Wall Interactions
    138. Section XX - Developmental Immunobiology

    139. Host Defense Mechanisms Against Bacteria
    140. Host-Fungi Interactions Relevant to the Newborn Infant
    141. Host Defense Mechanisms Against Viruses
    142. T-Cell Development
    143. B-Cell Development
    144. Mononuclear Phagocyte System
    145. Normal and Abnormal Neutrophil Physiology in the Newborn
    146. The Complement System of the Fetus and Newborn
    147. Cytokines and Inflammatory Response in the Fetus and Neonate
    148. Immunology of Human Milk and Host Immunity
    149. Neonatal Pulmonary Host Defense
    150. Section XXI - Neurology

    151. Development of the Nervous System
    152. Development of the Blood-Brain Barrier
    153. Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
    154. Intraventricular Hemorrhage in the Neonate
    155. Cerebellar Development – an Impact of Preterm Birth and Co-Morbidities
    156. Electroencephalography in the Premature and Full-Term Infant
    157. Developmental Aspects of Pain
    158. Section XXII - Special Sensory Systems in the Fetus and Neonate

    159. Early Development of the Human Auditory System
    160. Development of Taste and Smell in the Neonate
    161. Section XXIII - Orthopedics

    162. The Growth Plate: Embryologic Origin, Structure, and Function
    163. Ontogenesis of Striated Muscle
    164. Section XXIV - Endocrine Function

    165. Hypothalamus: Neuroendometabolic Center
    166. Growth Factor Regulation of Fetal Growth
    167. Growth Hormone in the Fetus and Newborn
    168. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
    169. Development of the Corticotropin-Releasing Hormone–Corticotropin System in the Mammalian Fetus
    170. Fetal and Neonatal Adrenocortical Physiology
    171. Fetal and Neonatal Thyroid Physiology
    172. Section XXV - Ovary and Testis

    173. Genetics of Sex Determination and Differentiation
    174. Differentiation of the Ovary
    175. Testicular Development and Descent
    176. Section XXVI - Pathophysiology of Neonatal Diseases

    177. Pathophysiology of Neonatal sepsis
    178. Pathophysiology of Hypoglycemia in the Neonate
    179. Pathophysiology of Cardiomyopathies
    180. Pathophysiology of Persistent pulmonary hypertension of the newborn
    181. Pathophysiology of Shock in the Fetus and Neonate
    182. Pathophysiology of Apnea of Prematurity
    183. Pathophysiology of Respiratory Distress Syndrome
    184. Pathophysiology of Meconium Aspiration Syndrome
    185. Pathophysiology of Bronchopulmonary Dysplasia
    186. Pathophysiology of Ventilator Dependent Infants
    187. Pathophysiology of Gastroesophageal Reflux
    188. Pathophysiology of Neonatal Necrotizing Enterocolitis
    189. Pathophysiology of Kernicterus
    190. Pathophysiology of neonatal acute kidney injury
    191. Pathophysiology of Edema
    192. Pathophysiology of Retinopathy of Prematurity
    193. Pathophysiology of Hypoxic-ischemic Brain Injury
    194. Pathophysiology of Neonatal White Matter Injury
    195. Pathophysiology of Meningitis
    196. Pathophysiology of Neural Tube Defects
    197. Pathophysiology of Preeclampsia
    198. Pathophysiology of Preterm Birth
    199. Pathophysiology of Chorioamnionitis


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    © Elsevier 2017
    1st July 2016
    Hardcover ISBN:
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    About the Authors

    Richard Polin

    Affiliations and Expertise

    William T. Speck Professor of Pediatrics, College of Physicians and Surgeons, Columbia University; Director, Division of Neonatology, Morgan Stanley Children’s Hospital of New York – Presbyterian, Columbia University Medical Center, New York, New York

    Steven Abman

    Affiliations and Expertise

    Professor of Pediatrics, University of Colorado School of Medicine; Director, Pediatric Heart Lung Center, Children’s Hospital Colorado, Denver, Colorado

    David Rowitch

    Affiliations and Expertise

    Professor of Pediatrics and Neurosurgery, Chief, Division of Neonatology, UCSF Benioff Children’s Hospital San Francisco, San Francisco, California

    William Benitz

    Affiliations and Expertise

    Philip Sunshine Professor in Neonatology, Chief, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Director of Nurseries, Lucile Packard Children’s Hospital, Palo Alto, California