Key Features

  • A cross-specialty book: brings together the work of specialists on the immature brain from the fields of obstetrics, paediatrics and neurosurgery.

  • An international book: edited and written by an international team of experts.

  • Highly illustrated: includes over 800 images and line drawings that capture the latest investigative techniques.

  • Focused on treatment: key points boxes pick out the most important information for the busy specialist.

  • Evidence-based information: extensively referenced with the latest and most important papers and articles.

Table of Contents

SECTION I Structural Development of the CNS

1. The molecular basis of brain development
2. Early embryonic development of the brain
3. Development of consciousness: fetal, neonatal and maternal interactions
4. Ultrasound assessment of normal fetal brain development
5. MR imaging of the fetal central nervous system
6. Imaging the neonatal brain

SECTION II Functional Assessment of CNS Development

7. Functional assessment of the fetal CNS
8. The development of senses
9. Clinical assessment of the infant nervous system
10. Perinatal cerebral circulation
11. Cerebral blood flow and energy metabolism in the developing brain
12. EEG and evoked potentials in the neonatal period


13. Congenital structural defects of the brain
14. Genetics of neurodevelopmental anomalies
15. Antenatal assessment of CNS anomalies, including neural tube defects
16. Transvaginal fetal neuroscan
17. Epidemiology and prevention of neural tube defects

SECTION IV Hemorrhagic and Ischemic Lesions

18. Fetal brain injury and multiple pregnancies
19. Infection, inflammation and brain injury
20. Neonatal intracranial hemorrhage
21. Cerebral ischemic lesions

SECTION V Perinatal Asphyxia

22. Pathophysiology of asphyxia
23. Antenatal prediction of asphyxia
24. Intrapartum monitoring for asphyxia
25. Prediction of asphyxia with fetal gas analysis
26. The asphyxiated newborn infant
27. Neuroprotection of the fetal and neonatal brain
28. Medico-legal issues: The United Kingdom perspective
29. Malpractice issues in perinatal medicine: The United States perspective

SECTION VI Infection of the CNS

30. Toxoplasmosis
31. Congenital viral infections and the central nervous system
32. Bacterial and fungal infectio


No. of pages:
© 2009
Churchill Livingstone
Print ISBN:
Electronic ISBN:

About the authors

Malcolm Levene

Malcolm Levene MD, FRCP, FRCPCH, FMedSc retired Professor of Paediatrics and Child Health, University of Leeds, Leeds General Infirmary Leeds