Fermentation Products - 1st Edition - ISBN: 9780080253855, 9781483148465

Fermentation Products

1st Edition

Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25, 1980

Editors: Claude Vezina Kartar Singh
eBook ISBN: 9781483148465
Imprint: Pergamon
Published Date: 1st January 1981
Page Count: 616
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Advances in Biotechnology, Volume III: Fermentation Products is the third of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume contains 87 papers organized into nine sections. The papers under Section I deal with developments in the field of secondary metabolism (functions of secondary metabolites in the producing organisms; roles of plasmids in the biosynthesis of secondary metabolites; and protoplast fusion in industrial microorganisms). Sections II to VII examine the fermentation of antibiotics; amino acids, vitamins, and nucleotides; microbial enzymes; products from immobilized cells and enzymes; mycotoxins; and biopolymers. The final two sections present studies on bioconversions. The volume also includes the invited keynote address of Professor Hamao Umezawa ""Problems and Trends in the Development of New Antibiotics and Other Useful Microbial Products"". This volume will be a valuable resource for students and researchers in industrial microbiology, biochemical engineering and related areas, as well as managers of biotechnology.

Table of Contents


Guest Editorial: Problems and Trends in the Development of New Antibiotics and Other Useful Microbial Products

Section I. New Aspects of Secondary Metabolites

1. Possible Functions of the Peptide Antibiotics Tyrocidine and Gramicidin during Sporulation

2. The Role of Secondary Metabolism in Penicillium brevicompactum

3. A Study of Secondary Growth of Streptomyces griseoruber

4. Role of Plasmid Genes in Aureothricin Production

5. Function of Plasmids in Producers of Macrolides

6. Unstable Pleiotropic Mutation in Streptomyoes lavendulae

7. Localization of Antimycin a and Melanin Determinants in Auxotrophs of Streptomyoes sp. M-506 and in Their Prototrophic Revertants

8. Characterization of a Plasmid from Bacillus brevis ATCC 9999

9. Genetics of Penicillin Producing Organisms

10. Penicillin Production by Recombinant Strains of Penicillium chrysogenum Obtained by Fusion of Protoplasts

11. Fusion of Protoplasts of Bacillus Species

12. Studies on the Nature of Vacuoles in Protoplasts of Claviceps purpurea

Section II. Antibiotics

13. Cell-Free Biosynthesis of Macrolides and Other "Polyketide" Antibiotics

14. Cell-Free Biosynthesis of Peptide Antibiotics

15. Enzymology of Chloramphenicol Biosynthesis

16. Biosynthesis of Streptomycins

17. Enzymatic Synthesis of the Antibiotic Gramicidin S: Kinetics of Inhibition and Enzyme Destabilization

18. Terminal Steps of Patulin Biosynthesis in Penicillium urticae

19. Synthesis of Enniatins by a Multienzyme

20. Biosynthesis of Daunorubicin Glycosides: Analysis with Blocked Mutants

21. Fermentation and Biosynthesis of Sagamicin and Related Aminoglycosides in Micromonospora Sagamiensis

22. Characterization of Mutants of Streptomyoes Griseus Deregulated or Blocked in Candicidin Biosynthesis: Molecular Mechanism of Control of Antibiotic Biosynthesis

23. Study of the Molecular Mechanism of Phosphate Control of Candicidin Biosynthesis Using Phosphate-Deregulated Mutants

24. Regulation by Aromatic Amino Acids at the p-Aminobenzoic Acid Synthetase Level in S. griseus

25. Nitrogen Regulation of Penicillin G Biosynthesis in Penicillium chrysogenum

26. Carbon Catabolite Repression of Penicillin Biosynthesis

27. Regulation of Homocitrate Synthetase by Lysine in Relation to Penicillin G Biosynthesis

28. The Use of Different 1-Phenyl-N-Alkanes for Benzylpenicillin Biosynthesis by Penicillium chrysogenum

29. Analysis of the Spectrum of Secondary Metabolites of an Industrial Macrolide-producing Strain of Streptomyces hygroscopious

30. Stimulation of Leucomycin Production by Magnesium Phosphate and its Relevance to Nitrogen Catabolite Regulation

31. Regulation of the A40104 Fermentation-Production of A40104A, a Pleuromutilin Glycoside Antibiotic

32. Nitrogen Catabolite Regulation of Streptothricin Biosynthesis by Streptomyces noursei JA 3890 B

33. A New Aminoglycoside SC4-Antibiotic: Producing Organism, Fermentation and its Biological Properties

34. Studies on the Cosynthesis and Metabolic Regulation of Rifamycin SV

Section III. Amino Acids, Vitamins and Nucleotides

35. Regulation of Primary Metabolism

36. Aromatic Amino Acid Hyperproducing Mutants of Esoheriohia coli: Biochemistry, Genetics and Fermentation Kinetics

37. Utilisation de l'activite α-aminoamidasique d'une bacterie nitrilasique pour la production d'acides α-mines Stereospecifiques

38. Advances in Studies on Breeding of Amino Acid-Producing Strains in China

39. Vitamin Fermentations: B2 and B12

40. Extracellular Metabolites from Phototrophic Bacteria as Possible Intermediates in the Biosynthesis of Vitamin B12

41. Effect of Amino Acids on the Production of Biotin and the Mechanism of the Regulation of Biotin Biosynthesis in Sporobolomyces pararoseus 2553

42. Antimetabolite Substances from Bacillus ceveus

43. Control of Fermentative Production of Sugar Nucleotides and Cytidine Derivatives by Yeasts

Section IV. Microbial Enzymes

44. Production of Thermostable Cellulases and Raw Starch-Digestible Amylases by Fungi

45. Increased Production of Cellulase of Trichoderma reesei in STR and HRR by pH Cycling and Temperature Profiling

46. Cellulase Process Improvement and its Economics

47. 1,4-ß-Glucanases and 1,4-ß-Glucosidases from Penicillium janthinellum: Production, Location, Adsorption and Regulation

48. Process for the Production of Yeast-Lytic Enzymes and the Disruption of Whole Yeast Cells

49. Optimization of Cultivation Medium Composition for Lytic Enzyme Biosynthesis

50. ß-amylase Production by a Rifampin-Resistant, Asporogenous Mutant of Bacillus cereus and its Sporogenous Revertant

51. Production of Thermostable Alpha Amylase by Bacillus Apiarius CBML 152

52. Enzymatic Synthesis of 2H or 3H-Labeled Amino Acids with L-Methionine γ-Lyase

53. Enzymatic Oxidation of Methanol to Produce Formaldehyde and Hydrogen Peroxide

54. Isolation and Purification of Enzymes by Complexing with Liquid Ion Exchangers

Section V. Products from Immobilized Cells and Enzymes

55. Synthetic Prepolymer Methods for Immobilization of Biocatalysts. Application of Gel-Entrapped Microbial Cells to Bioconversions of Lipophilic Compounds in Hydrophobic Conditions

56. Industrial Applications of Fiber-Entrapped Enzymes

57. Microbial Sensors for Fermentation Control

58. Microencapsulation of Multi-Enzyme Systems

59. Catalytic Properties of Immobilized Cells of Methane-Oxidizing and Methanogenic Bacteria

60. Production of α-Keto Acids with Alginate-Entrapped Whole Cells of the Yeast Trigonopsis variabilis

61. Basic Trials on the Conversion of Cellulosic Material to Ethanol Using Yeast Coimmobilized with Cellulolytic Enzymes

62. Inhibition of Free and Immobilized Xanthine Oxidase by 6-(p-X-phenyl)pteridin-4-ones (X=H, Me, OMe, Cl, Br)

63. Photochemical Fuel Cell Using Immobilized Chloroplast-Clostridium butyricum

Section VI. Mycotoxins

64. Secondary Metabolites as Chemical Signals between Species in an Ecological Niche

65. Taxonomic Problems of Toxinogenic Molds

66. Genetic Perspective on Polyketides, Productivity, Parasexuality, Protoplasts, and Plasmids

67. Genetic Analysis of Aflatoxin Production by Aspergillus parasiticus

68. Convenient Production, Resolution, and Isotope Labeling of Cytochalasin Congeners

Section VII. Biopolymers

69. Microbial Polysaccharides

70. Scleroglucan Biopolymer Production, Properties, and Economics

71. The Effect of Citrate and Other Organic Acids in Xanthan Production

72. Emulsan Production in Acinetobacter Rag-1

73. Interaction of Acinetobacter Rag-1 Emulsan with Hydrocarbons

74. Biosurfactant and Surface Phenomena Associated with Corynebacterium lepus

75. Formation of Surface Active Glycolipids by n-Alkane Utilizing Microorganisms

76. Kinetics of the Biotechnological Production of Poly-ß-Hydroxybutyric Acid

Section VIII. Bioconversions

77. Degradation of Deoxycholic Acid by a Pseudomonas sp.

78. Production of Chenodeoxycholic Acid by Bioconversion of Dehydrocholic Acid

79. Kinetics and Optimization of Steroid Transformation in a Mixed Culture

80. Microbial Reduction of Carbon 1 and 2 Double Bond in l-α-Santonin (Microbial Transformation. XVI)

81. Isolation of l-Menthol from a Mixture of Racemic Menthols by Rhodotorula mucilaginosa and Bacillus Strains

82. Microbiological Hydroxylation of Patchoulol

83. Microbial Oxidation of ß-Myrcene

Section IX. Other Fermentations and Bioconversions

84. Factors Regulating Product Formation in Streptococcus lactis

85. Regulation of Citric Acid Production in Aspergillus niger

86. Production of 6-Aminopenicillanic Acid from Penicillin V and G by Bovista plumbea NRRL 3824 and Escherichia coli 5K (pHM 12)

87. Assay of Thymidine Phosphorylase in Whole Cell Suspensions of Escherichia coli

Contents of Other Volumes

Volume I. Scientific and Engineering Principles

Volume II. Fuels, Chemicals, Foods and Waste Treatment

Contents of "current Developments in Yeast Research" (ISY-5)

Author Index

Subject Index


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© Pergamon 1981
eBook ISBN:

About the Editor

Claude Vezina

Kartar Singh

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