Factors Affecting Neurological Aging

Factors Affecting Neurological Aging

Genetics, Neurology, Behavior, and Diet

1st Edition - June 1, 2021

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  • Editors: Colin Martin, Victor Preedy, Rajkumar Rajendram
  • Hardcover ISBN: 9780128179901
  • eBook ISBN: 9780128179918

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Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.

Key Features

  • Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging
  • Features sections on the genetic components that influence aging and diseases of aging
  • Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
  • Includes more than 500 illustrations and tables


Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of Contents

  • Part I
    Genetics, Molecular and Cellular Biology

    1. Genetics of frontotemporal dementia
    Ebru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan

    2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism
    Ting Shen, Yuyi You, Vivek K. Gupta and Stuart L. Graham

    3. Aging, demented patients, and polymorphisms in cytokine genes
    Vanêssa Gomes Fraga, Paulo Caramelli and Karina Braga Gomes

    4. RNA fragments and brain aging
    Lingyu Guan and Andrey Grigoriev

    5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging
    Heide Schatten

    6. Brain aging and microarray analysis
    Cristina Sanfilippo and Michelino Di Rosa

    7. Human nuclear tau and aging
    Concetta Federico, Francesca Bruno, Valentina Sturiale, Agata Grazia D’Amico, Grazia Maugeri, Velia D’Agata, Laura Gil and Salvatore Saccone

    8. Lipoxidation: features, neurological tissues and aging
    Reinald Pamplona, Mariona Jové, Irene Pradas, Natalia Mota-Martorell and Isidro Ferrer

    9. Aging modifies concentration and metabolism of amino acids and associated receptor functionality in the brain
    Mitsuhiro Furuse

    10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia
    Michy Kelly

    11. The prohibitin complex in aging and neurodegeneration
    Andrea González-Morales, Mercedes Lachén-Montes, Karina Ausin, Paz Cartas-Cejudo, Naroa Mendizuri, Joaquín Fernández-Irigoyen and Enrique Santamaría

    12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process
    Roberto Villa and Federica Ferrari

    Part II
    Neurological and Imaging Features

    13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance Imaging
    Yu-Chien Wu

    14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiography
    Ruikang K. Wang and Yuandong Li

    15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view
    Jun Yamada and Shozo Jinno

    16. Grey-matter networks in aging
    Marisa Koini

    17. Changes in brain synapse-related molecules with age
    Kiyohito Mizutani and Yoshimi Takai

    18. Macroautophagy and chaperone-mediated autophagy in aging
    Tando Maduna, Andre du Toit and Ben Loos

    19. Neuronal L-type calcium channels in aging
    Joanne Koh, Sheeja Navakkode, Jing Zhai and Tuck Wah Soong

    20. The impact of aged microglia on D-serine-regulated glutamatergic transmission
    Sebastián Beltrán-Castillo, Rommy von Bernhardi and Jaime Eugenín

    21. Ion channels and the aging brain
    Federico Sesti and Alessandro Bortolami

    22. Dendritic spine remodeling and aging
    Benjamin D. Boros and Jeremy H. Herskowitz

    23. High-density lipoprotein-cholesterol and neuroaging: memory and gyrification of the insular and frontal opercular cortex
    Ryuta Kinno and Kenjiro Ono

    24. Astrocyte and microglial aging: morphology and modeling
    Tiffany A. Peterson and Andrew G. MacLean

    25. Cerebellum - aging of the neuronal machine
    Pavel Filip and Martin Bare

    26. Lipids, beta-secretase 1, and Alzheimer disease
    J. Villamil-Ortiz, B.J.L. Eggen and G.P. Cardona-Go´mez

    27. Aging, myelination and the optic nerve
    Ahmed Abdellatif and Hamdino Attia

    28. Linking proteostasis, aging, and brain ischemia
    Wei Yang, Ran Li, Xuan Li and Dennis A. Turner

    29. Luteinizing hormone and the aging nervous system
    Megan Mey and Gemma Casadesus

    30. Insights into aging using transcranial magnetic stimulation
    Jennifer I. Lissemore, Lauren Wengle, Zafiris J. Daskalakis and Daniel M. Blumberger

    31. Alpha rhythms: what they are and how they alter with aging
    Maria Knyazeva

    32. Nicotine and its derivatives in healthy brain aging
    Alireza Majdi and Saeed Sadigh-Eteghad

    Part III
    Physiological Aspects

    33. Environmental enrichment and physiological aging
    Yulia K. Komleva, Vladimir V. Salmin, Olga L. Lopatina, Olga A. Belova and Alla B. Salmina

    34. Treadmill exercise and neuroinflammation: links with aging
    Caroline Cristiano Real, Karina Henrique Binda and Anne Marlene Landau

    35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond
    Lars Stiernman Jonasson, Chelsea Stillman and Kirk I. Erickson

    36. The effects of cardiorespiratory fitness on brain and cognitive aging
    Daniel C. Bowie, Grace M. Clements, Gabriele Gratton and Monica Fabiani

    37. Aging, babble noise, and the processing of speech perception
    Hanani Abdul Manan, Noorazrul Azmie Yahya and Ahmad Nazlim Yusoff

    38. The blood-brain barrier in aging
    Luca Anna Bors and Franciska Erdő

    Part IV
    Behavior And Psychopathological Aspects

    39. Linking aging, anticholinergic drug use, and cognitive impairment
    Mariangela Boccardi and Virginia Boccardi

    40. Cognitive Frailty: Definitions, components and impact on disability, and mortality
    Francesco Panza, Maddalena La Montagna, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Gianluigi Giannelli and Madia Lozupone

    41. Cognitive impairment (brain) and (et) dynapenia (D) “BED” in older persons: role of arterial tree
    Marcello Maggio and Fulvio Lauretani

    42. Disentangling the effects of aging and ovarian hormone loss on sleep: implications for health and disease
    Gina Nicoll, Anne Almey and Nicole J. Gervais

    43. Role of DNA methylation in aging-related cognitive functioning
    Anna Starnawska and Nicklas Heine Staunstrup

    44. Depression in the elderly and psychobiotics
    Elnaz Vaghef-Mehrabany, Mehrangiz Ebrahimi-Mameghani, Mahzad Sanayei and Leila Vaghef-Mehrabany

    Part V
    Diet And Nutrition

    45. Aging, dietary patterns and cognition
    Angela Marie Abbatecola and Raffaele Marfella

    46. Geriatric nutritional risk index: applications and limitations
    Mahzad Sanayei, Elnaz Vaghef-Mehrabany and Leila Vaghef-Mehrabany

    47. Diet, inflammation, and neurocognitive aging
    Yian Gu

    48. The dietary approaches to stop hypertension (DASH) and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets and brain aging
    Samantha L. Gardener and Stephanie R. Rainey-Smith

    49. The ketogenic diet and healthy brain aging
    Georgia A.F. Rogerson and Victor R. Preedy

    50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)
    Kurt A. Escobar and Trisha A. VanDusseldorp

    51. Dietary Flavonoids and Brain Health in Ageing: food for Thought
    Catarina Rendeiro and Justin S. Rhodes

    52. Antioxidant effects of curcumin and neuroaging
    Shameemah Abrahams, Katelyn Cuttler, Minke Bekker, Jonathan Carr, Soraya Bardien and Okobi Ekpo

    53. Lipoic acid and vitamin D3 and their use in preventing brain aging
    Francesca Uberti, Sara Ruga, Vera Morsanuto, Mahitab Farghali and Claudio Molinari

    54. Effects of β>hydroxy-β-methyl>butyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in aging
    Amogh Belagodu, Shuo Kang, Joshua M. Gulley and Roberto Galvez

    55. Hydration, the brain, and aging
    Agata Białecka-Debek

Product details

  • No. of pages: 686
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: June 1, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128179901
  • eBook ISBN: 9780128179918

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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