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Factors Affecting Neurological Aging - 1st Edition - ISBN: 9780128179901, 9780128179918

Factors Affecting Neurological Aging

1st Edition

Genetics, Neurology, Behavior, and Diet

Editors: Colin Martin Victor Preedy Rajkumar Rajendram
Hardcover ISBN: 9780128179901
eBook ISBN: 9780128179918
Imprint: Academic Press
Published Date: 1st June 2021
Page Count: 686
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Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.

Key Features

  • Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging
  • Features sections on the genetic components that influence aging and diseases of aging
  • Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
  • Includes more than 500 illustrations and tables


Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of Contents

Part I
Genetics, Molecular and Cellular Biology

1. Genetics of frontotemporal dementia
Ebru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan

2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism
Ting Shen, Yuyi You, Vivek K. Gupta and Stuart L. Graham

3. Aging, demented patients, and polymorphisms in cytokine genes
Vanêssa Gomes Fraga, Paulo Caramelli and Karina Braga Gomes

4. RNA fragments and brain aging
Lingyu Guan and Andrey Grigoriev

5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging
Heide Schatten

6. Brain aging and microarray analysis
Cristina Sanfilippo and Michelino Di Rosa

7. Human nuclear tau and aging
Concetta Federico, Francesca Bruno, Valentina Sturiale, Agata Grazia D’Amico, Grazia Maugeri, Velia D’Agata, Laura Gil and Salvatore Saccone

8. Lipoxidation: features, neurological tissues and aging
Reinald Pamplona, Mariona Jové, Irene Pradas, Natalia Mota-Martorell and Isidro Ferrer

9. Aging modifies concentration and metabolism of amino acids and associated receptor functionality in the brain
Mitsuhiro Furuse

10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia
Michy Kelly

11. The prohibitin complex in aging and neurodegeneration
Andrea González-Morales, Mercedes Lachén-Montes, Karina Ausin, Paz Cartas-Cejudo, Naroa Mendizuri, Joaquín Fernández-Irigoyen and Enrique Santamaría

12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process
Roberto Villa and Federica Ferrari

Part II
Neurological and Imaging Features

13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance Imaging
Yu-Chien Wu

14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiography
Ruikang K. Wang and Yuandong Li

15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view
Jun Yamada and Shozo Jinno

16. Grey-matter networks in aging
Marisa Koini

17. Changes in brain synapse-related molecules with age
Kiyohito Mizutani and Yoshimi Takai

18. Macroautophagy and chaperone-mediated autophagy in aging
Tando Maduna, Andre du Toit and Ben Loos

19. Neuronal L-type calcium channels in aging
Joanne Koh, Sheeja Navakkode, Jing Zhai and Tuck Wah Soong

20. The impact of aged microglia on D-serine-regulated glutamatergic transmission
Sebastián Beltrán-Castillo, Rommy von Bernhardi and Jaime Eugenín

21. Ion channels and the aging brain
Federico Sesti and Alessandro Bortolami

22. Dendritic spine remodeling and aging
Benjamin D. Boros and Jeremy H. Herskowitz

23. High-density lipoprotein-cholesterol and neuroaging: memory and gyrification of the insular and frontal opercular cortex
Ryuta Kinno and Kenjiro Ono

24. Astrocyte and microglial aging: morphology and modeling
Tiffany A. Peterson and Andrew G. MacLean

25. Cerebellum - aging of the neuronal machine
Pavel Filip and Martin Bare

26. Lipids, beta-secretase 1, and Alzheimer disease
J. Villamil-Ortiz, B.J.L. Eggen and G.P. Cardona-Go´mez

27. Aging, myelination and the optic nerve
Ahmed Abdellatif and Hamdino Attia

28. Linking proteostasis, aging, and brain ischemia
Wei Yang, Ran Li, Xuan Li and Dennis A. Turner

29. Luteinizing hormone and the aging nervous system
Megan Mey and Gemma Casadesus

30. Insights into aging using transcranial magnetic stimulation
Jennifer I. Lissemore, Lauren Wengle, Zafiris J. Daskalakis and Daniel M. Blumberger

31. Alpha rhythms: what they are and how they alter with aging
Maria Knyazeva

32. Nicotine and its derivatives in healthy brain aging
Alireza Majdi and Saeed Sadigh-Eteghad

Part III
Physiological Aspects

33. Environmental enrichment and physiological aging
Yulia K. Komleva, Vladimir V. Salmin, Olga L. Lopatina, Olga A. Belova and Alla B. Salmina

34. Treadmill exercise and neuroinflammation: links with aging
Caroline Cristiano Real, Karina Henrique Binda and Anne Marlene Landau

35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond
Lars Stiernman Jonasson, Chelsea Stillman and Kirk I. Erickson

36. The effects of cardiorespiratory fitness on brain and cognitive aging
Daniel C. Bowie, Grace M. Clements, Gabriele Gratton and Monica Fabiani

37. Aging, babble noise, and the processing of speech perception
Hanani Abdul Manan, Noorazrul Azmie Yahya and Ahmad Nazlim Yusoff

38. The blood-brain barrier in aging
Luca Anna Bors and Franciska Erdő

Part IV
Behavior And Psychopathological Aspects

39. Linking aging, anticholinergic drug use, and cognitive impairment
Mariangela Boccardi and Virginia Boccardi

40. Cognitive Frailty: Definitions, components and impact on disability, and mortality
Francesco Panza, Maddalena La Montagna, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Gianluigi Giannelli and Madia Lozupone

41. Cognitive impairment (brain) and (et) dynapenia (D) “BED” in older persons: role of arterial tree
Marcello Maggio and Fulvio Lauretani

42. Disentangling the effects of aging and ovarian hormone loss on sleep: implications for health and disease
Gina Nicoll, Anne Almey and Nicole J. Gervais

43. Role of DNA methylation in aging-related cognitive functioning
Anna Starnawska and Nicklas Heine Staunstrup

44. Depression in the elderly and psychobiotics
Elnaz Vaghef-Mehrabany, Mehrangiz Ebrahimi-Mameghani, Mahzad Sanayei and Leila Vaghef-Mehrabany

Part V
Diet And Nutrition

45. Aging, dietary patterns and cognition
Angela Marie Abbatecola and Raffaele Marfella

46. Geriatric nutritional risk index: applications and limitations
Mahzad Sanayei, Elnaz Vaghef-Mehrabany and Leila Vaghef-Mehrabany

47. Diet, inflammation, and neurocognitive aging
Yian Gu

48. The dietary approaches to stop hypertension (DASH) and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets and brain aging
Samantha L. Gardener and Stephanie R. Rainey-Smith

49. The ketogenic diet and healthy brain aging
Georgia A.F. Rogerson and Victor R. Preedy

50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)
Kurt A. Escobar and Trisha A. VanDusseldorp

51. Dietary Flavonoids and Brain Health in Ageing: food for Thought
Catarina Rendeiro and Justin S. Rhodes

52. Antioxidant effects of curcumin and neuroaging
Shameemah Abrahams, Katelyn Cuttler, Minke Bekker, Jonathan Carr, Soraya Bardien and Okobi Ekpo

53. Lipoic acid and vitamin D3 and their use in preventing brain aging
Francesca Uberti, Sara Ruga, Vera Morsanuto, Mahitab Farghali and Claudio Molinari

54. Effects of β>hydroxy-β-methyl>butyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in aging
Amogh Belagodu, Shuo Kang, Joshua M. Gulley and Roberto Galvez

55. Hydration, the brain, and aging
Agata Białecka-Debek


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© Academic Press 2021
1st June 2021
Academic Press
Hardcover ISBN:
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About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

King’s College London, UK

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