Extrachromosomal DNA - 1st Edition - ISBN: 9780121987800, 9780323145350

Extrachromosomal DNA

1st Edition

Editors: Donald Cummings
eBook ISBN: 9780323145350
Imprint: Academic Press
Published Date: 28th January 1979
Page Count: 580
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Extrachromosomal DNA contains the proceedings of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology held in Keystone, Colorado. Contributors focus on extrachromosomal DNA, paying particular attention to the biogenesis of yeast mitochondria. They discuss topics based on the premise that the diversity and complexity of primitive mitochondrial and perhaps chloroplast DNA structure and replication have more in common with many viral systems than with either prokaryotic or eukaryotic systems. This is especially striking in the case of so-called split genes. This book is organized into nine sections encompassing 34 chapters and begins with an overview of extranuclear genetics and the evolution and regulation of mitochondrial biogenesis. The following chapters explore the genetic capacity and structure of chloroplast DNA, viral replication and function, and viral nucleic acids. The possibility of isolating mutants in some intervening sequences and analyzing their effect in loci of known genetic function is demonstrated. The reader is also introduced to the analysis of intervening genes and its importance in yeast mitochondria, as well as the sequencing of a variety of genes of known function. This book also considers the organization, function, and expression of extrachromosomal DNA in yeast, along with the genetics and biogenesis of mitochondrial DNA from higher eukaryotes, and then concludes with a description of the biological and structural characteristics of kinetoplast and Podospora mitochondrial DNA. This book will be of interest to researchers involved in mitochondrial, chloroplast, plasmid, and viral DNA function and replication.

Table of Contents

Contributors Preface I. Evolution and Extrachromosomal DNA

1. Extranuclear Genetics 2. Mitochondrial Biogenesis: Evolution and Regulation 3. Restriction Enzyme Analysis of Mitochondrial DNA from Closely Related Species of Paramecium 4. The Extrachromosomal Ribosomal RNA Genes in Tetrahymena; Structure and Evolution 5. Molecular Heterogeneity among Mitochondrial DNAs from Different Maize Cytoplasms

II. Genetic Capacity and Structure of Chloroplast DNA

6. Genetic Analysis of Chloroplast DNA Function in Chlamydomonas 7. Methylation and Restriction of Chloroplast DNA: The Molecular Basis of Maternal Inheritance in Chlamydomonas 8. Genes on the Maize Chloroplast Chromosome 9. Chloroplast DNA of Euglena gracilis: Gene Mapping and Selective in Vitro Transcription of the Ribosomal RNA Region

III. Models for Viral Replication and Function

10. The Mu Paradox: Excision versus Replication 11. Integration of Transposable DNA Elements: Analysis by DNA Sequencing 12. In Vitro Replication of Adenovirus DNA 13. Selective Conservation of the Origins of DNA Replication (Genomic Termini) in Spontaneous Deletion Mutants of the Parvovirus MVM

V. Sequence Analysis of Viral Nucleic Acids

14. Complex Structures and New Surprises in SV40 mRNA 15. Structure and Organization of Adenovirus 5 Transformation Genes 16. The Epstein-Barr Virus Plasmid

V. Organization, Function, and Expression of Yeast Extrachromosomal DNA

17. The Influence of the Nuclear and Mitochondrial Genomes on the Expression of Mitochondrial DNA in Saccharomyces cerevisiae 18. Genetic and Biochemical Analysis of Var 1 19. Transcription of Yeast Mitochondrial DNA 20. Transcripts of Yeast Mitochondrial DNA and Their Processing 21. The Expression in Saccharomyces cerevisiae of Bacterial β-Lactamase and Other Antibiotic Resistance Genes Integrated in a 2-μm DNA Vector

VI. Sequence Analysis of Fungal


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© Academic Press 1979
Academic Press
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About the Editor

Donald Cummings

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