Extrachromosomal DNA

1st Edition - January 28, 1979
Editor: Donald Cummings
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 5 3 5 - 0

Extrachromosomal DNA contains the proceedings of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology held in Keystone, Colorado. Contributors focus on extrachromosomal… Read more

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Extrachromosomal DNA contains the proceedings of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology held in Keystone, Colorado. Contributors focus on extrachromosomal DNA, paying particular attention to the biogenesis of yeast mitochondria. They discuss topics based on the premise that the diversity and complexity of primitive mitochondrial and perhaps chloroplast DNA structure and replication have more in common with many viral systems than with either prokaryotic or eukaryotic systems. This is especially striking in the case of so-called split genes. This book is organized into nine sections encompassing 34 chapters and begins with an overview of extranuclear genetics and the evolution and regulation of mitochondrial biogenesis. The following chapters explore the genetic capacity and structure of chloroplast DNA, viral replication and function, and viral nucleic acids. The possibility of isolating mutants in some intervening sequences and analyzing their effect in loci of known genetic function is demonstrated. The reader is also introduced to the analysis of intervening genes and its importance in yeast mitochondria, as well as the sequencing of a variety of genes of known function. This book also considers the organization, function, and expression of extrachromosomal DNA in yeast, along with the genetics and biogenesis of mitochondrial DNA from higher eukaryotes, and then concludes with a description of the biological and structural characteristics of kinetoplast and Podospora mitochondrial DNA. This book will be of interest to researchers involved in mitochondrial, chloroplast, plasmid, and viral DNA function and replication.

Contributors

Preface

I. Evolution and Extrachromosomal DNA

1. Extranuclear Genetics

2. Mitochondrial Biogenesis: Evolution and Regulation

3. Restriction Enzyme Analysis of Mitochondrial DNA from Closely Related Species of Paramecium

4. The Extrachromosomal Ribosomal RNA Genes in Tetrahymena; Structure and Evolution

5. Molecular Heterogeneity among Mitochondrial DNAs from Different Maize Cytoplasms

II. Genetic Capacity and Structure of Chloroplast DNA

6. Genetic Analysis of Chloroplast DNA Function in Chlamydomonas

7. Methylation and Restriction of Chloroplast DNA: The Molecular Basis of Maternal Inheritance in Chlamydomonas

8. Genes on the Maize Chloroplast Chromosome

9. Chloroplast DNA of Euglena gracilis: Gene Mapping and Selective in Vitro Transcription of the Ribosomal RNA Region

III. Models for Viral Replication and Function

10. The Mu Paradox: Excision versus Replication

11. Integration of Transposable DNA Elements: Analysis by DNA Sequencing

12. In Vitro Replication of Adenovirus DNA

13. Selective Conservation of the Origins of DNA Replication (Genomic Termini) in Spontaneous Deletion Mutants of the Parvovirus MVM

V. Sequence Analysis of Viral Nucleic Acids

14. Complex Structures and New Surprises in SV40 mRNA

15. Structure and Organization of Adenovirus 5 Transformation Genes

16. The Epstein-Barr Virus Plasmid

V. Organization, Function, and Expression of Yeast Extrachromosomal DNA

17. The Influence of the Nuclear and Mitochondrial Genomes on the Expression of Mitochondrial DNA in Saccharomyces cerevisiae

18. Genetic and Biochemical Analysis of Var 1

19. Transcription of Yeast Mitochondrial DNA

20. Transcripts of Yeast Mitochondrial DNA and Their Processing

21. The Expression in Saccharomyces cerevisiae of Bacterial β-Lactamase and Other Antibiotic Resistance Genes Integrated in a 2-μm DNA Vector

VI. Sequence Analysis of Fungal Mitochondrial DNA

22. Organization of Mitochondrial DNA in Yeast

23. Identification and Sequencing of Yeast Mitochondrial tRNA Genes in Mitochondrial DNA-pBR322 Recombinants

24. Mitochondrial tRNAs and rRNAs of Neurospora crassa: Sequence Studies, Gene Mapping, and Cloning

VII. Genetics and Biogenesis of Mitochondrial DNA from Higher Eucaryotes

25. Structure and Evolution of Animal Mitochondrial DNA

26. Structure and Replication of Mitochondrial DNA from the Genus Drosophila

27. Transcription Pattern of Drosophila melanogaster Mitochondrial DNA

VIII. Organization and Function of Mammalian Mitochondrial DNA

28. The Organization of the Genes in the Human Mitochondrial Genome and Their Mode of Transcription

29. Cloning of Human Mitochondrial DNA

30. Quantitation of Intrapopulation Variation by Restriction Endonuclease Analysis of Human Mitochondrial DNA

31. Restricted Mitochondrial DNA Fragments as Genetic Markers in Cytoplasmic Hybrids

IX. Biological and Structural Features of Kinetoplast and Podospora Mitochondrial DNA

32. Structure and Function of Kinetoplast DNA of the African Trypanosomes

33. Replication and Transcription of Kinetoplast DNA

34. Mitochondrial DNA and Senescence in Podspora anserina

Index