Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.

Key Features

@introbul:Key Features @bul:* Organized and written by world-renowned experts * Covers state-of-the-art experimental methods * Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies


Basic and clinical scientists, biophysicits, biochemits, cell biologists, cell physiologists, biotechnologists, and pharmaceutical companies.

Table of Contents

Extracellular Nucleotide and Nucleoside Signaling: First Principles Introduction: ATP and its Metabolites as Potent Extracellular Agents Cellular Mechanisms and Physiology of Nucleotide and Nucleoside Release from Cells: Current Knowledge, Novel Assays to Detect Purinergic Agonists, and Future Directions Molecular and Biological Properties of P2Y Receptors Extracellular ATP-gated P2X Purinergic Receptor Channels Molecular and Cell Biology of Adenosine Receptors Relating the Structure of ATP-gated Ion Channel-receptors to their Function Epithelial Purinergic Receptors and Signaling in Health and Disease Nucleotide Release and Purinergic Signaling in the Vasculature Driven by the Red Blood Cell A Purine Signal for Functional Hyperemia in Skeletal and Cardiac Muscle Purinergic Receptors in the Nervous System Purinergic (P2) Receptors in the Kidney Purinergic Receptors and Hepatobiliary Function ATP in the Treatment of Advanced Cancer Purinergic Receptors in the Glomerulus and Vasculature of the Kidney


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© 2003
Academic Press
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