Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects

Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects

1st Edition - June 23, 2003

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  • Editor: Erik Schwiebert
  • eBook ISBN: 9780080490977

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Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.

Key Features

@introbul:Key Features
@bul:* Organized and written by world-renowned experts
* Covers state-of-the-art experimental methods
* Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies


Basic and clinical scientists, biophysicits, biochemits, cell biologists, cell physiologists, biotechnologists, and pharmaceutical companies.

Table of Contents

  • Extracellular Nucleotide and Nucleoside Signaling: First Principles
    Introduction: ATP and its Metabolites as Potent Extracellular Agents
    Cellular Mechanisms and Physiology of Nucleotide and Nucleoside Release from Cells: Current
    Knowledge, Novel Assays to Detect Purinergic Agonists, and Future Directions
    Molecular and Biological Properties of P2Y Receptors
    Extracellular ATP-gated P2X Purinergic Receptor Channels
    Molecular and Cell Biology of Adenosine Receptors
    Relating the Structure of ATP-gated Ion Channel-receptors to their Function
    Epithelial Purinergic Receptors and Signaling in Health and Disease
    Nucleotide Release and Purinergic Signaling in the Vasculature Driven by the Red Blood Cell
    A Purine Signal for Functional Hyperemia in Skeletal and Cardiac Muscle
    Purinergic Receptors in the Nervous System
    Purinergic (P2) Receptors in the Kidney
    Purinergic Receptors and Hepatobiliary Function
    ATP in the Treatment of Advanced Cancer
    Purinergic Receptors in the Glomerulus and Vasculature of the Kidney

Product details

  • No. of pages: 497
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: June 23, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080490977

About the Serial Volume Editor

Erik Schwiebert

Affiliations and Expertise

University of Alabama, Birmingham, U.S.A.

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