Extracellular Matrix  - 1st Edition - ISBN: 9780123333209, 9780323150415

Extracellular Matrix

1st Edition

Editors: Susan Hawkes
eBook ISBN: 9780323150415
Imprint: Academic Press
Published Date: 28th January 1982
Page Count: 436
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Extracellular Matrix contains the proceedings of the symposium ""The Extracellular Matrix,"" sponsored by the Michigan Molecular Institute and held in Midland, Michigan, on June 28-July 2, 1982. The papers explore the role played by the extracellular matrix (ECM) in the physiology of a cell, particularly in the regulation of cellular phenotypes, differentiation, and proliferation. The progress made in isolating and defining the chemistry and functional interactions of the ECM components is discussed, along with the biology of the ECM. This book is comprised of 52 chapters and begins with an introduction to the ECM, with emphasis on the question of whether the malignant process can be defined in a cell culture model, and in particular, whether the pericellular matrix is characteristically altered in cancer. The discussion then turns to the structure of the heparan sulfate proteoglycans and the molecular mechanisms responsible for the association of these molecules with the surfaces of cultured cells. Subsequent chapters focus on the chemistry of ECM components such as collagen, glycosaminoglycans, and adhesive glycoproteins, along with their functional interactions, biosynthesis, turnover, and degradation. The final section is devoted to the diseased states of ECM. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

Table of Contents




Perspectives in Extracellular Matrix Research: The Role of Cell Culture Models

I Chemistry of ECM components: Collagens, Glycosaminoglycans,and Adhesive Glycoproteins

Heparan Sulfate: On the Structure and Function of the Cell-Associated Proteoglycans

Structure and Function of Fibronectin

Structure and Biosynthesis of Cartilage Collagens

Interactions and Assembly of Basement Membrane Components

II Systems for Studying the Role of ECM in Growth and Differentiation

Cell-Matrix Interaction in Embryonic Avian Cornea and Lens

Patterns of Proteoglycan Synthesis during Chondrogenesis

Proteoglycan Synthesis by Proliferating, Non-Proliferating, and Senescent Cultures of Human Embryo Lung Fibroblasts

III Cell-Substratum Adhesion and Adhesion-Deficient Cell ines

The Effect of Different Proteoglycans on Serum-Mediated Cell Adhesion and Spreading

Adhesions and Cellular Adhesion

Selection of Substratum-Specific Adhesion Variants of Rat Hepatoma (HTC) Cells

Characterization of Cell Surface Heparan Sulfates Produced by Adhesion-Deficient Cell Lines

On the Mechanism of Cell Adhesion to Substratum in Metastatic and Other Tumor Cells

IV Biological Effects of the ECM in Tissue Interactions and Differentiation

Scanning Electron Microscopy (SEM) of the Extracellular Matrix Meshwork during Cranial Neural Crest Cell Migration in Chick Embryos

The Role of the Extracellular Matrix in the Control of Neural Crest Cell Migration

Tunicamycin-Induced Defects in the Mouse Embryo: An In Vitro Study

Proteins of the Embryonic Extracellular Matrix: Regional and Temporal Correlation with Tissue Interaction in the Heart

Parameters Influencing Formation and Migration of Cardiac Mesenchymal Cells in Three-Dimensional Collagen Gels

Collagen Biosynthesis as a Key Regulatory Step in the Hormone-Induced Differentiation of the Mouse Mammary Gland

Influence of Extracellular Matrix, Laminin, and Fibronectin on the Growth of Cultured Mammalian Lens Epithelial Cells

The Role of ECM in the Development of Invertebrates: A Phylogeneticist's View

Glycosaminoglycans in and around Transplantable Hepatomas of Varying Growth Rates and Metastatic Characteristics

The Extracellular Matrix in the Control of Prostate Cell Growth

V Functional Interactions of ECM Components

Functions for Fibronectin, Hyaluronate, and Heparan Proteoglycans in Substratum Adhesion of Fibroblasts

Transformation-Dependent Alterations in the Composition and Interactions of Glycoproteins in the Extracellular Matrix of Human Fibroblasts: Characteristics of GP140 and GP250

Transformation Specific Protein of the Extracellular Matrix

Carbohydrates Protect the Collagen-Binding Domain of Fibronectin against Proteolytic Degradation

VI Growth of Cells on Surfaces Derivatized with ECM Components

Extracellular Matrix and Morphogenesis: Collagen Overlay Induces Lumen Formation by Epithelial Cell Lines

Extracellular Glycoprotein Mediates the Binding of Hyaluronate to In Situ Migrating Chick Cardiac Mesenchyme

VII Structural and Functional Studies of the Components of the ECM

Studies on the Major Carbohydrate from Human Placental Cellular Fibronectin

Specific Attachment of Collagen to Cardiac Myocytes: In Vivo and In Vitro

Laminin and Heparan Sulfate in Matrix Attachment of Teratocarcinoma-Derived Endodermal Cells

An Integral Membrane Proteoglycan is Capable of Binding Components of the Cytoskeleton and the Extracellular Matrix

Subcellular Sites of Elongation of Hyaluronate

Suppression of Sulfated-Proteoglycan Biosynthesis in Chondrocyte Cultures by Calcium Ionophores

Immunochemical Analysis of cAMP during Murine Limb Chondrogenesis In Vitro

A Biochemical Profile of the ECM during the Sequential Stages of Otic Capsule Formation In Vivo and In Vitro

Elaboration of Extracellular Matrix and Reverse Transformation of Chinese Hamster Ovary Cells

VIII Modulation of Mammary Cell Phenotypes by the ECM

Modulation of the Differentiated Phenotype of Cultured Mouse Mammary Epithelial Cells by Collagen Substrata

Growth and Differentiation of Rat Mammary Epithelium on Mammary Gland Extracellular Matrix

Effects of Collagen Gel Matrix on the Growth of Cultured Mouse Mammary Cells

The Role of Collagenous Substrata on the Production of Basement Membrane Proteins by Rat Mammary Epithelial Cells In Vitro

IX Biosynthesis, Turnover, and Degradation of ECM Components

The Effect of Mannose-6-Phosphate on the Turnover of the Components of the Extracellular Matrix

Biosynthetic Studies on Fibronectin and Chondroitin Sulphate Proteoglycans in Human Melanoma Cells

Transformation-Dependent Changes in Hyaluronic Acid Synthetase Activity and Its Product

The Effects of Taxol on Chondroblast Proteoglycan Secretion

Studies on Glycosaminoglycan-Dependent Protease Inhibitors

X Diseased States of ECM

Metastatic Tumor Cell Attachment to and Invasion of Organ Tissue and Artificial Vascular Endothelium In Vitro

Degradation of Cartilage Matrix by Yoshida Sarcoma Cells

Abnormalities in the Production of Extracellular Matrix by Cells from Individuals with Inherited Disorders of Collagen Biosynthesis

Defective Conversion of a Glycoprotein Precursor to Keratan Sulfate Proteoglycan in Macular Corneal Dystrophy

Alterations in the Basement Membrane in Diabetes



No. of pages:
© Academic Press 1982
Academic Press
eBook ISBN:

About the Editor

Susan Hawkes

Ratings and Reviews