Extracellular Matrix

Extracellular Matrix

1st Edition - January 28, 1982

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  • Editor: Susan Hawkes
  • eBook ISBN: 9780323150415

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Extracellular Matrix contains the proceedings of the symposium ""The Extracellular Matrix,"" sponsored by the Michigan Molecular Institute and held in Midland, Michigan, on June 28-July 2, 1982. The papers explore the role played by the extracellular matrix (ECM) in the physiology of a cell, particularly in the regulation of cellular phenotypes, differentiation, and proliferation. The progress made in isolating and defining the chemistry and functional interactions of the ECM components is discussed, along with the biology of the ECM. This book is comprised of 52 chapters and begins with an introduction to the ECM, with emphasis on the question of whether the malignant process can be defined in a cell culture model, and in particular, whether the pericellular matrix is characteristically altered in cancer. The discussion then turns to the structure of the heparan sulfate proteoglycans and the molecular mechanisms responsible for the association of these molecules with the surfaces of cultured cells. Subsequent chapters focus on the chemistry of ECM components such as collagen, glycosaminoglycans, and adhesive glycoproteins, along with their functional interactions, biosynthesis, turnover, and degradation. The final section is devoted to the diseased states of ECM. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

Table of Contents

  • Participants



    Perspectives in Extracellular Matrix Research: The Role of Cell Culture Models

    I Chemistry of ECM components: Collagens, Glycosaminoglycans,and Adhesive Glycoproteins

    Heparan Sulfate: On the Structure and Function of the Cell-Associated Proteoglycans

    Structure and Function of Fibronectin

    Structure and Biosynthesis of Cartilage Collagens

    Interactions and Assembly of Basement Membrane Components

    II Systems for Studying the Role of ECM in Growth and Differentiation

    Cell-Matrix Interaction in Embryonic Avian Cornea and Lens

    Patterns of Proteoglycan Synthesis during Chondrogenesis

    Proteoglycan Synthesis by Proliferating, Non-Proliferating, and Senescent Cultures of Human Embryo Lung Fibroblasts

    III Cell-Substratum Adhesion and Adhesion-Deficient Cell ines

    The Effect of Different Proteoglycans on Serum-Mediated Cell Adhesion and Spreading

    Adhesions and Cellular Adhesion

    Selection of Substratum-Specific Adhesion Variants of Rat Hepatoma (HTC) Cells

    Characterization of Cell Surface Heparan Sulfates Produced by Adhesion-Deficient Cell Lines

    On the Mechanism of Cell Adhesion to Substratum in Metastatic and Other Tumor Cells

    IV Biological Effects of the ECM in Tissue Interactions and Differentiation

    Scanning Electron Microscopy (SEM) of the Extracellular Matrix Meshwork during Cranial Neural Crest Cell Migration in Chick Embryos

    The Role of the Extracellular Matrix in the Control of Neural Crest Cell Migration

    Tunicamycin-Induced Defects in the Mouse Embryo: An In Vitro Study

    Proteins of the Embryonic Extracellular Matrix: Regional and Temporal Correlation with Tissue Interaction in the Heart

    Parameters Influencing Formation and Migration of Cardiac Mesenchymal Cells in Three-Dimensional Collagen Gels

    Collagen Biosynthesis as a Key Regulatory Step in the Hormone-Induced Differentiation of the Mouse Mammary Gland

    Influence of Extracellular Matrix, Laminin, and Fibronectin on the Growth of Cultured Mammalian Lens Epithelial Cells

    The Role of ECM in the Development of Invertebrates: A Phylogeneticist's View

    Glycosaminoglycans in and around Transplantable Hepatomas of Varying Growth Rates and Metastatic Characteristics

    The Extracellular Matrix in the Control of Prostate Cell Growth

    V Functional Interactions of ECM Components

    Functions for Fibronectin, Hyaluronate, and Heparan Proteoglycans in Substratum Adhesion of Fibroblasts

    Transformation-Dependent Alterations in the Composition and Interactions of Glycoproteins in the Extracellular Matrix of Human Fibroblasts: Characteristics of GP140 and GP250

    Transformation Specific Protein of the Extracellular Matrix

    Carbohydrates Protect the Collagen-Binding Domain of Fibronectin against Proteolytic Degradation

    VI Growth of Cells on Surfaces Derivatized with ECM Components

    Extracellular Matrix and Morphogenesis: Collagen Overlay Induces Lumen Formation by Epithelial Cell Lines

    Extracellular Glycoprotein Mediates the Binding of Hyaluronate to In Situ Migrating Chick Cardiac Mesenchyme

    VII Structural and Functional Studies of the Components of the ECM

    Studies on the Major Carbohydrate from Human Placental Cellular Fibronectin

    Specific Attachment of Collagen to Cardiac Myocytes: In Vivo and In Vitro

    Laminin and Heparan Sulfate in Matrix Attachment of Teratocarcinoma-Derived Endodermal Cells

    An Integral Membrane Proteoglycan is Capable of Binding Components of the Cytoskeleton and the Extracellular Matrix

    Subcellular Sites of Elongation of Hyaluronate

    Suppression of Sulfated-Proteoglycan Biosynthesis in Chondrocyte Cultures by Calcium Ionophores

    Immunochemical Analysis of cAMP during Murine Limb Chondrogenesis In Vitro

    A Biochemical Profile of the ECM during the Sequential Stages of Otic Capsule Formation In Vivo and In Vitro

    Elaboration of Extracellular Matrix and Reverse Transformation of Chinese Hamster Ovary Cells

    VIII Modulation of Mammary Cell Phenotypes by the ECM

    Modulation of the Differentiated Phenotype of Cultured Mouse Mammary Epithelial Cells by Collagen Substrata

    Growth and Differentiation of Rat Mammary Epithelium on Mammary Gland Extracellular Matrix

    Effects of Collagen Gel Matrix on the Growth of Cultured Mouse Mammary Cells

    The Role of Collagenous Substrata on the Production of Basement Membrane Proteins by Rat Mammary Epithelial Cells In Vitro

    IX Biosynthesis, Turnover, and Degradation of ECM Components

    The Effect of Mannose-6-Phosphate on the Turnover of the Components of the Extracellular Matrix

    Biosynthetic Studies on Fibronectin and Chondroitin Sulphate Proteoglycans in Human Melanoma Cells

    Transformation-Dependent Changes in Hyaluronic Acid Synthetase Activity and Its Product

    The Effects of Taxol on Chondroblast Proteoglycan Secretion

    Studies on Glycosaminoglycan-Dependent Protease Inhibitors

    X Diseased States of ECM

    Metastatic Tumor Cell Attachment to and Invasion of Organ Tissue and Artificial Vascular Endothelium In Vitro

    Degradation of Cartilage Matrix by Yoshida Sarcoma Cells

    Abnormalities in the Production of Extracellular Matrix by Cells from Individuals with Inherited Disorders of Collagen Biosynthesis

    Defective Conversion of a Glycoprotein Precursor to Keratan Sulfate Proteoglycan in Macular Corneal Dystrophy

    Alterations in the Basement Membrane in Diabetes


Product details

  • No. of pages: 436
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323150415

About the Editor

Susan Hawkes

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