Extracellular Matrix Influences on Gene Expression

1st Edition - January 1, 1975
Editor: Harold Slavkin
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 2 1 4 - 4

Extracellular Matrix Influences on Gene Expression emerged from the Second international Santa Catalina Island Colloquium that deals with the discussion on the advances in the… Read more

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Extracellular Matrix Influences on Gene Expression emerged from the Second international Santa Catalina Island Colloquium that deals with the discussion on the advances in the molecular biology of extracellular matrices and the epigenetic influences on cell function. Topics discussed include morphological descriptions, genetics, teratology, collagen heterogeneity, and mineralization. The book's 12 chapters discuss the chromosomal and extrachromosomal influences upon transcription, translational and post-translational regulations during development, and regulation of extracellular matrix molecular biosynthesis. The book describes the regulation of tissue-specific collagen biosynthesis and the extracellular matrix macromolecules. It contains papers that explain the outer cell surface specificity and cell interactions. Because there are advances as well in other specific topics, such as the epithelial-masenchymal interactions and extracellular matrix influences on gene expression, this book contains papers that deal with these subject matters. Furthermore, it explains the matrix-cell and cell-matrix interactions and mineralization processes, as well as the aberrations in developmental processes. This book will be useful to those individuals who study the scientific advances in developmental biology.

Photographs of Participants

Participants and Coauthors

Administrative Staff

Preface

Introductory Note

Part I Extracellular Matrix Influences on Gene Expression

1. Craniofacial Anomalies: Past, Present, and Future Priorities for Developmental and Molecular Biology

2. Developmental Role of Intercellular Matrix: Retrospection and Prospection

Part II Chromosomal and Extrachromosomal Influences upon Transcription

3. Studies on Cartilage Differentiation

4. On the Mechanism of Repression and De-repression of Gene Function with 5-Bromo-2'-Deoxyuridine and Dimethyl Sulfoxide

5. Role of Glucocorticoid Receptors in Steroid Induced Protein Synthesis

6. The Control of Chondrogenic and Myogenic Expression in Chick Limb Mesodermal Cells

7. Cell Recognition, Histotypic Adhesion and Enzyme Induction in Embryonic Cells

8. Preparation of Minicells, Microcells and Anucleate Cells and Their Use in Cell Fusion Experiments

9. A New Hypothesis for the Regulation of Gene Expression

Discussion

Part III Translational and Post-Translational Regulation during Development

10. The Structure, Synthesis, and Secretion of Pro-collagen

11. Assembly and Processing of Pro-collagen

12. Possible Control of Collagen Synthesis by Specific Isoaccepting tRNA Species

13. Elaboration of Precursor Collagen by Osteoblasts as Visualized by Radioautography after 3 H-Proline Administration

14. Peptides of Basement Membrane Proteins after Cyanogen Bromide and Potassium Cyanide Cleavage

15. Collagenolytic Activity in Human Platelets

16. The Effects of Homologous and Heterologous tRNA on the Synthesis of Submaxillary Gland Proteins in vitro

Discussion

Part IV Regulation of Extracellular Matrix Macromolecular Biosynthesis

17. Chondrogenic Differentiation in Cultured Somites

18. The Influence of External Potassium on the Accumulation of Matrix Components by Chondrocytes in vitro

19. Control of Corneal Differentiation in vitro by Extracellular Matrix

20. Role of Enzyme-Enzyme Interactions in the Organization of Multi-Enzyme Systems

21. Hyaluronic Acid-Proteoglycan Interaction and the Influence of Hyaluronic Acid on Proteoglycan Synthesis by Chondrocytes from Adult Cartilage

22. The Relation of Phagocytosis to the Secretion of Non-Lysosomal Enzymes by Connective Tissue Cells

23. The Regulation of Collagen Fibril Formation

24. Epithelial-Specific Extracellular Matrix Influences on Mesenchyme Collagen Biosynthesis in vitro

25. Generation of Cell Diversity

Discussion

Part V Regulation of Tissue-Specific Collagen Synthesis

26. Biosynthesis of Type III Collagen: Relative Insolubility of the Molecules Synthesized in the Presence of a Lathyrogen

27. Biosynthesis of Collagen by Chondrocytes in vitro

28. The Biosynthesis of Type II Collagen (Cartilage) During Limb Morphogenesis and Regeneration

29. Collagen of Rat Skin and Bovine Articular Cartilage: Their Hydrodynamic Properties During Interactions with Proteoglycans

30. Intracellular Transport and Secretion of Pro-collagen in Chick Bone as Shown by E.M. Radioautography and Biochemical Analysis

31. Collagen Fibrillogenesis in vitro and in vivo: The Existence of Unique Aggregates and the Special State of the Fibril End

32. Proteoglycan-Collagen Interaction: Possible Developmental Significance

33. The Existence of Chemically Distinct Soluble Collagens in Prenatal and Post-natal Bovine Skin and Tendon

Discussion

Part VI Extracellular Matrix Macromolecules

34. Proteins of the Periodontium: The Chain Structure of the Collagens of Bovine Cementum and Periodontal Ligament

35. Some Electrostatic Properties of Reconstituted Collagen Fibrils

36. Enamel Proteins: Identification of Epithelial-Specific Differentiation Products

37. Glycosaminoglycan Conformations

38. Keratan Sulfate of Cartilage and Nucleus Pulposus

39. Organization of Extracellular Matrix in Bovine Articular Cartilages

40. The Structure of Cartilage Proteoglycans

41. Regulation of Epiphyseal Cartilage Maturation

Discussion

Part VII Outer Cell Surface Specificities and Cell Interactions

42. Tissue-Specific Differences and Membrane Site Mobility in Intercellular Adhesion

43. Influence of Antigenic Matrices on the Antibody Response

44. The Location and Nature of Molecules Potentially Involved in Morphogenesis of the Developing Nervous System

45. Lectins: Probes for Cell Surface Structure and Architecture

46. The Influence of Tissue Interactions and Extracellular Macromolecules on the Control of Phenotypic Expression and Synthetic Capacity of Bone and Cartilage

Discussion

Part VIII Epithelial-Mesenchymal Interactions

47. How Are Embryonic Preameloblasts Instructed by Odontoblasts to Synthesize Enamel?

48. Transmission and Spread of Kidney Tubule Induction

49. Control of DNA Synthesis in the Embryonic Pancreas: Interaction of the Mesenchymal Factor and Cyclic AMP

50. Epithelial-Mesenchymal Interactions Between Developing Chick Epidermis and Rabbit Embryo Mammary Mesenchyme

51. On Odontogenic Tissue Interactions

52. Tissue Environmental Influences on the Development of Melanoblasts in Steel Mice

53. Epithelial Cell Differentiation During Secondary Palate Development

Discussion

Part IX Extracellular Matrix Influences on Gene Expression

54. Extracellular Factors Controlling the Migration and Differentiation of the Ganglioblasts of the Autonomie Nervous System

55. Collagen Synthesis in Cultured Neural Crest Cells, Their Derivatives and Retinal Pigmented Epithelium: Stimulation of (α1)3 Collagen Production

56. A Substratum of Bone Matrix Gelatin for Chondrogenesis in Tissue Culture and in vivo

57. Collagenous Bone Matrix and Gene Expression in Fibroblasts

58. Bone Formation in HeLa Cell-Mouse Thigh Tumors Explanted to Mouse Brain

59. Mechanical Influences on the Biosynthesis of Extracellular Macromolecules by Aortic Cells

60. The Enhancement of Chondrogenesis of Predetermined Limb Bud Cells by Cartilage-Conditioned Medium

61. Control of the Phenotypic Vertebral Cartilage Differentiation by the Periaxial Extracellular Material

62. Perinotochordal Proteoglycans and Somite Chondrogenesis

Discussion

Part X Matrix-Cell and Cell-Matrix Interactions and Mineralization Processes

63. The Extracellular Control of Cellular Metabolism in Bone

64. Evidence for an Organic Nucleational Agent of Calcium Phosphate Mineral Forms in Endochondral Plates

65. Role of Organic Matrix in Calcification

66. Role of the Matrix in the Process of Mineralization

67. Evidence for a Role of Lysozyme in Endochondral Calcification During Healing of Rickets

68. Histochemical and Ultrastructural Investigations on Calcification of the Aorta

69. The Endosteal Cell Response to Exogenous Stimuli, An Electron Microscope Study

Discussion

Part XI Aberrations in Developmental Processes

70. Inhibition of Tumor Angiogenesis by a Diffusible Factor from Cartilage

71. The Neural Crest in Normal and Abnormal Craniofacial Development

72. Tissue Differentiation and Fibrocartilage Mineralization in Fracture Healing

73. The Multi-Step Pathway of Collagen Biosynthesis: Pro-collagen Intermediates

74. Function of the Genetically Distinct Collagens

Discussion

Part XII Reflections and Summary

Index