Extracellular Matrix in Development and Disease

Extracellular Matrix in Development and Disease

1st Edition - November 18, 2005

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  • Editor: Jeffrey Miner
  • Hardcover ISBN: 9780444518460

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Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules.

Key Features

* Written by leaders in the field
* Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer
* Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia
* Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more


Matrix biologists, developmental biologists, cell biologists

Table of Contents

  • 1. Type IV Collagen: A Network for Development, Differentiation and Disease
    Scott J. Harvey and Paul S. Thorner

    2. Role of perlecan in development and diseases
    Eri Arikawa-Hirasawa

    3. Extracellular Matrix Gene Expression in the Developing Mouse Aorta
    Sean E. McLean, Brigham H. Mecham, Cassandra M. Kelleher,
    Thomas J. Mariani, and Robert P. Mecham

    4. Basement membrane and extracellular matrix molecules in the skin
    Julia Tzu, Jie Li, and M. Peter Marinkovich

    5. Integrin signaling and central nervous system development
    Richard Belvindrah and Ulrich Müller

    6. Extracellular matrix and inner ear development and function
    Dominic Cosgrove and Michael Anne Gratton

    7. Role of ECM components in cancer progression
    Roy Zent and Ambra Pozzi

Product details

  • No. of pages: 248
  • Language: English
  • Copyright: © Elsevier Science 2006
  • Published: November 18, 2005
  • Imprint: Elsevier Science
  • Hardcover ISBN: 9780444518460

About the Editor

Jeffrey Miner

Affiliations and Expertise

Wahington University School of Medicine, St. Louis, Missouri, U.S.A.

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