Extracellular Matrix Genes - 1st Edition - ISBN: 9780126181555, 9780323157667

Extracellular Matrix Genes

1st Edition

Authors: Charles Boyd
eBook ISBN: 9780323157667
Imprint: Academic Press
Published Date: 28th September 1990
Page Count: 286
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Extracellular Matrix Genes provides some of the interesting complexities of the structure of the entire family of extracellular matrix genes. This book illustrates the permanent role that molecular biology and molecular genetics play in the detailed understanding of the normal biology of extracellular matrix.

Organized into 10 chapters, this book begins with an overview of the structural and sequence aspects of the entire family of genomic sequences with a view to establishing common functional domains among collagens and their genes. This text then examines the status of the literature concerning human types. III and V. Other chapters consider the FACIT collagen gene family. This book discusses as well the development in understanding the structure of small proteoglycan core proteins and their role in proteoglycan biosynthesis and function as a result of their molecular cloning and expression. The final chapter deals with mutations in collagen genes.

This book is a valuable resource for biochemists.

Table of Contents



Conserved and Divergent Sequence and Functional Elements within Collagen Genes

I. Introduction

II. Collagens

III. Fibrillar Collagen Gene Structure

IV. Exon Sizes in the C- and N-Terminal Domains of Fibrillar Collagen Genes

V. The Structure of the Nonfibrillar Collagen Genes

VI. Introns

VII. The Origins of the Structure of Present Day Collagen Genes

VIII. Regulatory Sequences—Promotors

IX. Regulatory Sequences—CpG Islands

X. Regulatory Sequences—Enhancer Elements

XI. Alternative Exon Usage in Collagen Genes

XII. Untranslated Exon Sequences in Collagen Genes

XIII. Conclusions


Type III and V Procollagens: Homology in Genetic Organization and Diversity in Structure

I. Introduction

II. Cloning and Sequencing of α1(III) and α2(V) cDNA Recombinants

III. The Types III and V Genes Are Structurally Related to Types I and II

IV. The α1(III) and α2(V) Procollagen Genes Are Syntenic on Human Chromosome 2

V. Restriction Fragment Length Polymorphisms Associated with the α1(III) Locus

VI. Multiple mRNAs Are Transcribed from the α1(III) and α2(V) Procollagen Genes

VII. Primary and Secondary Structural Comparisons of the Triple Helix and C-Propeptide Domains of the Types I, III, and V Procollagen Chains

VIII. Concluding Remarks


The Molecular Biology of Collagens with Short Triple-Helical Domains

I. Introduction

II. Type IX Collagen Genes

III. The Type XII Collagen Gene

IV. The Function of Type IX and XII Collagens

V. The Type X Collagen Gene

VI. Type VIII Collagen Genes

VII. The Function of Type VIII and X Collagens


Structure and Evolution of Collagen IV Genes

I. Introduction

II. Properties of Collagen IV

III. Two Collagen IV Chains Are Linked on Human Chromosome 13

IV. Extensive Similarity between the C-Terminal Peptides of Collagens IV

V. Rate of Evolution in Collagen IV

VI. Collagen IV Genes Are Different

VII. How Similar Are α1(IV) and α2(IV)?

VIII. Summary


Molecular Biology of Cartilage Proteoglycan (Aggrecan) and Link Protein

I. Introduction

II. Link Protein cDNA and Gene Structure

III. Aggrecan cDNA and Gene Structure

IV. Conclusion


Structure and Role of Cloned Small Proteoglycans

I. Introduction

II. Syndecan

III. Fibroblast Cell Surface Heparan Sulfate Proteoglycan

IV. Serglycin

V. Invariant Chain Proteoglycan

VI. Decorin

VII. Biglycan (PGI)

VIII. Glycosaminoglycan Attachment Signal


Genes for the Human Laminin B1 and B2 Chains

I. Introduction

II. cDNA Clones Encoding Human Laminin BI and B2 Chains

III. Structure of the Genes for Human Laminin BI and Β2 Chains


The Fibronectin Gene

I. Protein Structure and Function

II. The Structure of the Gene

III. Concluding Remarks


Structure of the Elastin Gene and Alternative Splicing of Elastin mRNA

I. Introduction

II. cDNA Cloning and Sequence Analysis

III. Structure of Elastin Genes

IV. Species Comparison of Elastin Genes

V. Intron Structure

VI. Abundance of Repetitive Sequences of the Alu Family

VII. Copy Number of Elastin Gene

VIII. Alternative Splicing of Elastin mRNA

IX. Conclusions


Mutations in Collagen Genes: Biochemical and Phenotypic Consequences

I. Introduction

II. Approaches to the Identification of Mutations in Collagen Genes

III. Multiexon Rearrangements in Type I Collagen Genes Are Lethal but Are Tolerated in Type III Collagen if the Protein Product Is Synthesized

IV. Point Mutations: Relation of the Phenotype to the Location and Nature of the Substituting Amino Acid

V. Exon Deletion: Mechanisms and Phenotypic Correlates

VI. Altered "Expression" Usually Results in Mild Phenotypes

VII. Molecular-Phenotypic Correlation

VIII. Concluding Remarks




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Academic Press
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About the Author

Charles Boyd

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