Extracellular Matrix Genes

Extracellular Matrix Genes

1st Edition - September 28, 1990

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  • Author: Charles Boyd
  • eBook ISBN: 9780323157667

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Extracellular Matrix Genes provides some of the interesting complexities of the structure of the entire family of extracellular matrix genes. This book illustrates the permanent role that molecular biology and molecular genetics play in the detailed understanding of the normal biology of extracellular matrix. Organized into 10 chapters, this book begins with an overview of the structural and sequence aspects of the entire family of genomic sequences with a view to establishing common functional domains among collagens and their genes. This text then examines the status of the literature concerning human types. III and V. Other chapters consider the FACIT collagen gene family. This book discusses as well the development in understanding the structure of small proteoglycan core proteins and their role in proteoglycan biosynthesis and function as a result of their molecular cloning and expression. The final chapter deals with mutations in collagen genes. This book is a valuable resource for biochemists.

Table of Contents

  • Contributors


    Conserved and Divergent Sequence and Functional Elements within Collagen Genes

    I. Introduction

    II. Collagens

    III. Fibrillar Collagen Gene Structure

    IV. Exon Sizes in the C- and N-Terminal Domains of Fibrillar Collagen Genes

    V. The Structure of the Nonfibrillar Collagen Genes

    VI. Introns

    VII. The Origins of the Structure of Present Day Collagen Genes

    VIII. Regulatory Sequences—Promotors

    IX. Regulatory Sequences—CpG Islands

    X. Regulatory Sequences—Enhancer Elements

    XI. Alternative Exon Usage in Collagen Genes

    XII. Untranslated Exon Sequences in Collagen Genes

    XIII. Conclusions


    Type III and V Procollagens: Homology in Genetic Organization and Diversity in Structure

    I. Introduction

    II. Cloning and Sequencing of α1(III) and α2(V) cDNA Recombinants

    III. The Types III and V Genes Are Structurally Related to Types I and II

    IV. The α1(III) and α2(V) Procollagen Genes Are Syntenic on Human Chromosome 2

    V. Restriction Fragment Length Polymorphisms Associated with the α1(III) Locus

    VI. Multiple mRNAs Are Transcribed from the α1(III) and α2(V) Procollagen Genes

    VII. Primary and Secondary Structural Comparisons of the Triple Helix and C-Propeptide Domains of the Types I, III, and V Procollagen Chains

    VIII. Concluding Remarks


    The Molecular Biology of Collagens with Short Triple-Helical Domains

    I. Introduction

    II. Type IX Collagen Genes

    III. The Type XII Collagen Gene

    IV. The Function of Type IX and XII Collagens

    V. The Type X Collagen Gene

    VI. Type VIII Collagen Genes

    VII. The Function of Type VIII and X Collagens


    Structure and Evolution of Collagen IV Genes

    I. Introduction

    II. Properties of Collagen IV

    III. Two Collagen IV Chains Are Linked on Human Chromosome 13

    IV. Extensive Similarity between the C-Terminal Peptides of Collagens IV

    V. Rate of Evolution in Collagen IV

    VI. Collagen IV Genes Are Different

    VII. How Similar Are α1(IV) and α2(IV)?

    VIII. Summary


    Molecular Biology of Cartilage Proteoglycan (Aggrecan) and Link Protein

    I. Introduction

    II. Link Protein cDNA and Gene Structure

    III. Aggrecan cDNA and Gene Structure

    IV. Conclusion


    Structure and Role of Cloned Small Proteoglycans

    I. Introduction

    II. Syndecan

    III. Fibroblast Cell Surface Heparan Sulfate Proteoglycan

    IV. Serglycin

    V. Invariant Chain Proteoglycan

    VI. Decorin

    VII. Biglycan (PGI)

    VIII. Glycosaminoglycan Attachment Signal


    Genes for the Human Laminin B1 and B2 Chains

    I. Introduction

    II. cDNA Clones Encoding Human Laminin BI and B2 Chains

    III. Structure of the Genes for Human Laminin BI and Β2 Chains


    The Fibronectin Gene

    I. Protein Structure and Function

    II. The Structure of the Gene

    III. Concluding Remarks


    Structure of the Elastin Gene and Alternative Splicing of Elastin mRNA

    I. Introduction

    II. cDNA Cloning and Sequence Analysis

    III. Structure of Elastin Genes

    IV. Species Comparison of Elastin Genes

    V. Intron Structure

    VI. Abundance of Repetitive Sequences of the Alu Family

    VII. Copy Number of Elastin Gene

    VIII. Alternative Splicing of Elastin mRNA

    IX. Conclusions


    Mutations in Collagen Genes: Biochemical and Phenotypic Consequences

    I. Introduction

    II. Approaches to the Identification of Mutations in Collagen Genes

    III. Multiexon Rearrangements in Type I Collagen Genes Are Lethal but Are Tolerated in Type III Collagen if the Protein Product Is Synthesized

    IV. Point Mutations: Relation of the Phenotype to the Location and Nature of the Substituting Amino Acid

    V. Exon Deletion: Mechanisms and Phenotypic Correlates

    VI. Altered "Expression" Usually Results in Mild Phenotypes

    VII. Molecular-Phenotypic Correlation

    VIII. Concluding Remarks



Product details

  • No. of pages: 286
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: September 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323157667

About the Author

Charles Boyd

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