The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix.

Key Features

@introbul:Key Features @bul:* Addresses assembly of most of the known classes of extracellular matrix macromolecules * Discusses higher order structures produced by ECM * Gives important concepts in: @subbul:* ECM and cell-matrix interactions * Protein structure and protein-protein interactions * Development and tissue remodeling


Researchers and graduate students in cell, developmental, and molecular biology and biochemistry; also biomedical and biophysical researchers.

Table of Contents

J. Engel, Concepts of Self-Assembly in Biological Systems. A. Veils and A. George, Fundamentals of Interstitial Collagen Self-Assembly. D.J. Prockop and D.J.S. Hulmes, Assembly of Collagen Fibrilsde Novo from Soluble Precursors: Polymerization and Copolymerization of Procollagen, pN-Collagen, and Mutated Collagens. D.E. Birk and T.F. Linsenmayer, Collagen Fibril Assembly, Deposition, and Organization into Tissue- Specific Matrices. R.G. Brewton and R. Mayne, Heterotypic Type II, IX, and XI Fibrils: Comparison of Vitreous and Cartilage Forms. T.M. Schmid, A.A. Cole, Q. Chen, D.K. Bonen, L. Luchene, and T.F. Linsenmayer, Assembly of Type X Collagen by Hypertrophic Chondrocytes. R. Timpl and M.-L. Chu, Microfibrillar Collagen Type VI. K.G. Vogel, Glycosaminoglycans and Proteoglycans. R.P. Mecham and E.C. Davis, Elastic Fiber Structure and Assembly. D.M.P. Peters and D.F. Mosher, Formation ofFibronectin Extracellular Matrix. P.D. Yurchenco, Assembly of Laminin and Type IV Collagen into Basement Membrane Networks. U. Mayer and R. Timpl, Nidogen: A Versatile Binding Protein of Basement Membranes. D.R. Gerecke, M.K. Gordon,D.W. Wagman, M.F. Champliaud, and R.E. Burgeson, Hemidesmosomes, Anchoring Filaments, and Anchoring Fibrils: Components of a Unique Attachment Complex. J.M. Fitch and T.F. Linsenmayer, Interstitial Basement Membrane Components in Development. Chapter References. Index.


No. of pages:
© 1994
Academic Press
eBook ISBN:
Print ISBN:

About the editor

Peter Yurchenco

Affiliations and Expertise

Robert Wood Johnson Medical School, Piscataway, New Jersey, U.S.A.


@qu:"I liked this book very much, it will play a very useful role in my research and I can heartily recommend its purchase and wide-spread use." @source:--CELL BIOLOGY INTERNATIONAL