Extracellular Matrix and The Liver

Extracellular Matrix and The Liver

Approach to Gene Therapy

1st Edition - February 6, 2003

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  • Editors: Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott Friedman
  • eBook ISBN: 9780080531502

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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches. The chapters are divided into six sections as follows: Basic Science of Extracellular Matrix Cells Responsible for Extracellular Matrix Production Activation Mechanism of Hepatic Cells and Signal Transduction Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases New Strategies for the treatment of Liver Cirrhosis

Key Features

  • Discusses the possibility of gene therapy for liver cirrhosis
  • Includes information on new aspects of hepatic stellate cells
  • Written by top experts in basic science and clinical hepatology


Hepatologists, molecular geneticists, gastroenterologists, oncologists, and hematologists

Table of Contents

  • New Insights into the Extracellular Matrix
    Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors
    Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates
    Functions of Proteoglycan/Glycosaminoglycan in Liver
    SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology
    Cells Responsible for ECM Production in the Liver
    Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential
    Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair
    Molecular Mechanism of Stellate Cell Activation and ECM Remodeling
    Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype
    Knockout Mice of Matrix Metalloproteinase Genes
    Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis

Product details

  • No. of pages: 512
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: February 6, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080531502

About the Editors

Isao Okazaki

Affiliations and Expertise

Tokai University School of Medicine, Tokyo, Japan

Yosifumi Ninomiya

Affiliations and Expertise

Okayama University Medical School, Japan

Tanikawa Kyuichi

Affiliations and Expertise

Kurume University School of Medicine, Japan

Scott Friedman

Affiliations and Expertise

Mount Sinai School of Medicine, New York, NY, USA

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