Experimental Models of Infection, Inflammation and Injury

Experimental Models of Infection, Inflammation and Injury

1st Edition - April 1, 2022
  • Editor: David Montrose
  • Hardcover ISBN: 9780323899451

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Description

Experimental Models of Infection, Inflammation and Injury, Volume 168 provides step-by-step protocols for scientific researchers to effectively utilize experimental model systems. Chapters in this new release include Induction and Evaluation of Murine T Cell Transfer Colitis, Modelling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity, Mouse models of Graft-Versus-Host Disease, Preclinical Model of Multiple Sclerosis: Methods in Autoimmune Demyelination, Preclinical model of Multiple Sclerosis: focal, chemical or demyelination, Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips, and more. Other notable sections cover Rheumatoid Arthritis: Methods for Two Murine Models, Induction of Pancreatitis in Mice with Susceptibility to Pancreatic Cancer, Small Animal Models of Thermal Injury, Large Animal Models of Thermal Injury, Small animal models of localized heart irradiation, Methods for Induction and Assessment of Intestinal Permeability in Rodent Models of Radiation Injury, and more.

Key Features

  • Provides precise, step-by-step guidance on how to implement experimental systems
  • Presents a comprehensive background on the disease the model is being used to study
  • Offers insights into how the described disease models compare to other existing systems

Readership

Scientific researchers who would like to utilize experimental systems to study infection, inflammation and injury

Table of Contents

    1. Induction and evaluation of murine colitis induced by T cell transfer

    Suchandrima Saha, Ji Dong K Bai, David C. Montrose

    2. Modeling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity

    Jasmin Scheurer, Frank Leithäuser, Klaus-Michael Debatin and Gudrun Strauss

    3. Mouse models of graft-versus-host disease

    Dilan A. Patel, Mark A. Schroeder, Jaebok Choi and John F. DiPersio

    4. Preclinical model of multiple sclerosis: Methods in autoimmune demyelination

    Jillian C. Nissen and Stella E. Tsirka

    5. Preclinical model of multiple sclerosis: Focal, chemical or viral demyelination

    Stella E. Tsirka and Jillian C. Nissen

    6. Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: Workflow and practical tips

    Rianne P. Gorter, Naomi S. Dijksman, Wia Baron and Holly Colognato

    7. Rheumatoid arthritis: Methods for two murine models

    Aisha M. Mergaert, Thomas F. Warner and Miriam A. Shelef

    8. Induction of pancreatitis in mice with susceptibility to pancreatic cancer

    Sarah B. Gitto, Sai Preethi Nakkina, Jordan M. Beardsley, Jignesh G. Parikh and Deborah A. Altomare

    9. Small animal models of thermal injury

    Roohi Vinaik, Ayesha Aijaz and Marc G. Jeschke

    10. Large animal models of thermal injury

    Ayesha Aijaz, Roohi Vinaik and Marc G. Jeschke

    11. Small animal models of localized heart irradiation

    Marjan Boerma, Vijayalakshmi Sridharan, Kimberly J. Krager and Snehalata A. Pawar

    12. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury

    Laura E. Ewing, Prabath G. Biju, Rupak Pathak, Stepan Melnyk, Martin Hauer-Jensen and Igor Koturbash

    13. Methods and protocols for translatable rodent models of postsurgical pain

    James W. Morgan, Sarah D. Pennypacker, E. Alfonso Romero-Sandoval and Miriam M. Fonseca

    14. Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel

    Sarah D. Pennypacker, Miriam M. Fonseca, James W. Morgan, Patrick M. Dougherty, Juan R. Cubillos-Ruiz, Roy E. Strowd and E. Alfonso Romero-Sandoval

    15. The use of foodborne infection to evaluate bacterial pathogenesis and host response

    Timothy H. Chu, Zhijuan Qiu and Brian S. Sheridan

    16. Methods to evaluate virus-mediated acute lung inflammation

    Hannah M. Ivester, Juselyn D. Tupik, Margaret A. Nagai-Singer, Sheryl L. Coutermarsh-Ott and Irving C. Allen

    17. Induction and analysis of systemic C. albicans infections in mice

    David Frank and Nick Carpino

Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323899451

About the Serial Volume Editor

David Montrose

Dr. Montrose received his B.A. in Biology from Manhattanville College and his Ph.D. in Biomedical Science from the University of Connecticut (Health Center campus). He received his post-doctoral training at Weill Cornell Medical College of Cornell University. He is currently an Assistant Professor and lab head in the Department of Pathology at Stony Brook University School of Medicine and a member of the Stony Brook Cancer Center. Dr. Montrose is also a member of the Molecular and Cellular Pharmacology (MCP) and Molecular Genetics and Microbiology (MGM) graduate programs.

Affiliations and Expertise

Assistant Professor and Lab Head, Department of Pathology, Stony Brook University School of Medicine, NY, USA