Experimental Chemotherapy

Experimental Chemotherapy

1st Edition - January 1, 1963

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  • Editors: R. J. Schnitzer, Frank Hawking
  • eBook ISBN: 9781483273082

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Description

Experimental Chemotherapy, Volume I, attempts to condense the existing knowledge in the broad field of experimental chemotherapy in a comprehensive form. The arrangement of the subject matter follows a plan by which the not always avoidable repetitive description is reduced to a minimum. In most of the protozoan and metazoan infections it appeared advantageous to discuss the different series of active compounds according to the specific diseases and their causative agents. In other cases, owing to the wide range of activity of certain antibacterials, the material is arranged according to the groups of compounds. This first volume deals with infections caused by parasites, both protozoan and metazoan; it also contains general chapters on history of chemotherapy, toxicology, statistics, and drug resistance. It is hoped that the treatise will be useful to experimental workers engaged in the search for new chemotherapeutic remedies and in the study of their mechanism of action; to all who are involved in the teaching of pharmacology and therapeutics; and to physicians and veterinarians interested in the experimental basis of the drugs they are using.

Table of Contents


  • Contributors

    Preface

    1. History of Chemotherapy

    I. Introduction

    II. Early Development by Ehrlich (Trypanosomes and Spirochetes)

    III. Compounds against Malaria and Other Parasitic Infections

    IV. Statistics

    V. Achievements Up to 1930

    VI. Sulfonamides

    VII. Antibiotics

    VIII. Position of Chemotherapy

    IX. Analysis of Chemotherapeutic Research

    X. Conclusion

    References

    2. Toxicity in Chemotherapy

    I. Introduction

    II. Acute Toxicity

    III. Prolonged Toxicity

    IV. Unpredictable Toxicities

    V. Conclusion

    Appendix: Dose and Animal Size

    References

    3. Statistical Evaluation in Chemotherapy

    I. Introduction

    II. General Considerations

    III. Variability

    IV. Distribution

    V. History

    VI. Types of Response

    VII. The Quantal Response

    VIII. The Quantitative Response

    IX. Relative Activity

    X. The Screening of New Compounds

    Summary of Symbols Used

    References

    4. Drug Resistance in Chemotherapy

    I. Introduction

    II. Development of Resistant Forms

    III. Attributes of Drug Resistance

    IV. Mechanism of Drug Resistance

    V. Drug Dependence

    VI. Origin of Drug Resistance

    VII. Drug Antagonism and Synergism: Relation to Drug Resistance

    VIII. General Considerations

    References

    5. Chemotherapy of Trypanosomiasis

    Part 1: Principles and Techniques

    I. Basic Biological Principles

    II. Techniques for Measuring Chemotherapeutic Activity

    Part 2: Chemotherapeutic Effects of Active Compounds

    I. Arsenicals

    II. Antimonials

    III. Acridine Compounds

    IV. Suramin

    V. Diamidines

    VI. Phenanthridinium Compounds

    VII. Quinaldine and Quinoline Derivatives

    VIII. Furans and Nitrofurans

    IX. Triphenylmethane Dyes

    X. Antibiotics

    XI. Miscellaneous

    Part 3 : Mechanism of Activity of Drugs on Trypanosomes

    I. Types of Trypanocidal Activity

    II. Fixation of Drug by Trypanosomes

    III. Secondary Chemical Reactions between the Drug and Cell Constituents

    IV. Response of the Cell to Injury, i.e. Death

    V. Drug Resistance in Trypanosomes

    VI. Antagonism

    VII. Photosensitization

    VIII. Role of Reticuloendothelial System

    References

    6. Chemotherapy of Leishmaniasis

    I. Basic Biological Principles

    II. General Techniques for Measuring Chemotherapeutic Activity

    III. Chemotherapeutic Effects of Active Compounds

    References

    7. Chemotherapy of Trichomonad Infections

    I. Basic Biological Principles

    II. Chemotherapeutic Activity

    III. General Considerations

    References

    8. Chemotherapy of Histomoniasis

    I. Basic Biological Principles

    II. General Techniques for Measuring Chemotherapeutic Activity

    III. Active Compounds

    IV. Mode of Action of Drugs against Histomonas

    References

    9. Chemotherapy of Giardiasis

    I. Biological Principles

    II. Laboratory Studies

    III. Clinical

    References

    10. Chemotherapy of Amebiasis

    I. Basic Biological Principles

    II. General Techniques for Measuring Chemotherapeutic Activity

    III. Chemotherapeutic Agents against Entamoeba histolytica

    IV. Principles of Mechanism of Activity

    Acknowledgments

    References

    11. Chemotherapy of Coccidiosis

    I. Basic Biological Principles

    II. General Techniques for Measuring Chemotherapeutic Activity

    III. Active Compounds

    IV. Mechanism of Coccidistatic Activity

    References

    12. Chemotherapy of Malaria

    Part 1: Biological Basis of Testing Methods

    I. Introduction

    II. General Biological Principles

    III. Evaluation of Antimalarial Activity

    Part 2: The Antimalarial Drugs

    I. Chemotherapeutic Effects of the Specifically Active Compounds

    II. Principles of Mechanism of Activity

    References

    13. Chemotherapy of Babesiasis

    I. Basic Biological Principles

    II. Criteria of Efficacy of Drugs

    III. Active Compounds

    IV. Mechanism of Activity

    References

    14. Chemotherapy of Theileriasis

    I. Basic Biological Principles

    II. Techniques for Measuring Chemotherapeutic Activity

    III. Chemotherapeutic Effects of Active Compounds

    References

    15. Chemotherapy of Anaplasmosis

    I. Basic Biological Principles

    II. Techniques for Measuring Chemotherapeutic Activity

    III. Chemotherapeutic Effects of Specifically Active Compounds

    References

    16. Chemotherapy of Toxoplasmosis

    I. Introduction

    II. Method of Screening for Activity against Acute Toxoplasmosis

    III. Comparing the Effects of Drugs against Toxoplasmosis

    IV. Determination of Synergism

    V. Method of Testing for Activity against the Cysts

    VI. Summary of Drugs Found Active against Experimental Toxoplasmosis

    VII. Use of Metabolites to Alleviate Drug Toxicity

    VIII. Drug Resistance

    IX. Application of Experimental Findings to Treatment in Man

    References

    17. Chemotherapy of Balantidiasis

    I. Biological Principles

    II. Laboratory Studies

    III. Clinical

    References

    18. Chemotherapy of Spirochetal Infections

    I. Introduction

    II. Borrelia

    III. Treponema

    IV. Leptospira

    V. Comparison of the Activity of Therapeutic Agents on Treponemataceae

    References

    19. Chemotherapy of Miscellaneous Infections

    I. Infections Caused by Hexamita

    II. Besnoitiosis

    III. Sarcosporidiasis

    IV. Infections Caused by Pneumocystis carinii

    V. Infections Caused by Haemobartonella

    VI. Infections Caused by Grahamella

    VII. Infections Caused by Eperythrozoon

    VIII. Infections Caused by Bartonella bacilliformis

    IX. Infections Caused by Spirillum minus

    References

    20. Chemotherapy of Helminthic Infections

    I. Experimental Approach and Organization in Chemotherapy with Particular Reference to Anthelmintics

    II. Chemotherapy of Cestode Infections

    III. Chemotherapy of Trematode Infections

    IV. Chemotherapy of Nematode Infections (Filaria not Included)

    Acknowledgments

    References

    21. Chemotherapy of Filariasis

    I. Basic Biological Principles

    II. General Techniques for Measuring Chemotherapeutic Activity

    III. Chemotherapeutic Effects of Active Compounds

    IV. General Comments

    References

    22. Chemotherapy of Myiasis

    I. Introduction

    II. Determination of Chemotherapeutic Activity

    III. Organophosphates in General

    IV. Specific Organophosphate Compounds

    V. Generalizations

    References

    Author Index

    Subject Index

Product details

  • No. of pages: 1024
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9781483273082

About the Editors

R. J. Schnitzer

Frank Hawking

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