Experimental Chemotherapy V4

Experimental Chemotherapy V4

1st Edition - January 1, 1966

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  • Editor: R Schnitzer
  • eBook ISBN: 9780323143301

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Experimental Chemotherapy, Volume IV: Chemotherapy of Neoplastic Diseases, Part I focuses on the use of chemotherapy to counteract neoplastic ailments. The book first discusses the chemotherapy of neoplastic diseases, and this includes approaches to cancer chemotherapy, methods of drug evaluation, and the effects of antitumor antibiotics. The text also presents an appendix to the previous volumes. Toxicity and drug resistance in chemotherapy; chemotherapy of trypanosomiasis, giardiasis, and histomoniasis; and the use of antibiotics in chemotherapy are discussed. Experiments on the processes, methodologies, and medical interventions on the chemotherapy of these ailments are given importance. The book also identifies some antibiotics used in the chemotherapy of fungal and bacterial infections. These antibiotics include pimaricin, fucidin, gramicidin, lincomycin, and rifamycin SV. The book is a vital reference for readers wanting to explore the potential of chemotherapy on medical interventions on neoplastic diseases.

Table of Contents

  • Contributors


    Contents of Volume I

    Contents of Volume II

    Contents of Volume III

    Contents of Volume V

    Chemotherapy of Neoplastic Diseases I

    1. Approaches to Cancer Chemotherapy



    2. Methods of Drug Evaluation

    I. Introduction

    II. Screening Systems in Cancer Chemotherapy

    III. Design of Screening Procedures

    IV. Design of Comparative Investigations

    V. Mechanism of Drug Action

    VI. Toxicological Investigations


    3. Antimetabolites

    I. Introduction

    II. Aminopterin and Related Compounds

    III. Some Other Folic Acid Antagonists

    IV. 6-Mercaptopurine

    V. 6-Thioguanine

    VI. Some Other Substituted Purines, with Particular Reference to Derivatives of 6-Mercaptopurine and 6-Thioguanine

    VII. 8-Azaguanine

    VIII. 5-Fluoropyrimidines and Their Ribosides

    IX. Iodo- and Bromopyrimidine Deoxyribosides

    X. 6-Azauracil and 6-Azauridine

    XI. Some Other Pyrimidine Derivatives and Analogs

    XII. 1-Aminocyclopentanecarboxylic Acid (ACP)

    XIII. Other Amino Acid Analogs


    4. Antitumor Antibiotics

    I. Introduction

    II. The Actinomycins

    III. Mitomycin C

    IV. Azaserine

    V. DON (6-Diazo-5-oxo-L-norleucine)

    VI. Puromycin

    VII. Sarkomycin

    VIII. Cycloheximide, E73, and the Streptovitacins

    IX. Carzinophilin

    X. Chromomycin A3 (Toyomycin)

    XI. Antibiotic 6270

    XII. Streptonigrin

    XIII. Fumagillin and Fumagillin Alcohol

    XIV. Psicofuranine

    XV. Hadacidin

    XVI. Actinogan and Peptinogan

    XVII. Miscellaneous Antibiotics


    Appendix: Survey of Recent Developments in Experimental Chemotherapy: Supplements to Volumes I, II, and III

    Supplement to Volume I

    Toxicity in Chemotherapy

    Statistical Evaluation in Chemotherapy

    Drug Resistance in Chemotherapy

    Chemotherapy of Trypanosomiasis

    Chemotherapy of Trichomoniasis

    Chemotherapy of Histomoniasis

    Chemotherapy of Giardiasis

    Chemotherapy of Amebiasis

    Chemotherapy of Coccidiosis

    Chemotherapy of Malaria. Part 2. The Antimalarial Drugs

    Chemotherapy of Babesiasis

    Chemotherapy of Theileriasis and Anaplasmosis

    Chemotherapy of Toxoplasmosis

    Chemotherapy of Balantidiasis

    Chemotherapy of Spirochetal Infections

    Chemotherapy of Miscellaneous Infections

    Chemotherapy of Filariasis

    Chemotherapy of Myiasis

    Supplement to Volume II

    Chemotherapy with Antibacterial Dyestuffs

    Acridine Dye Action at Cellular and Molecular Levels

    Microbial Resistance to Harsh and Destructive Environmental Conditions

    Antibacterial Chemotherapy with Sulfonamides

    The Nitrofurans—Chemotherapeutic Properties

    Antibacterial Agents of Limited Action

    Experimental Chemotherapy of Leprosy

    Supplement to Volume III

    The Tetracyclines

    The Macrolides (Erythromycin Group)

    The Polypeptides of the Polymyxin Group


    Antibiotics Used in the Chemotherapy of Bacterial and Fungal Infections

    Chemotherapy of Rickettsial Infections

    Experiences with Experimental Chemotherapy of Viral Diseases

    Bibliographic List of Recent Publications Not Discussed in This Supplement

    Author Index

    Subject Index

Product details

  • No. of pages: 694
  • Language: English
  • Copyright: © Academic Press 1966
  • Published: January 1, 1966
  • Imprint: Academic Press
  • eBook ISBN: 9780323143301

About the Editor

R Schnitzer

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