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Experimental Chemotherapy V4 - 1st Edition - ISBN: 9780123955647, 9780323143301

Experimental Chemotherapy V4

1st Edition

Editor: R Schnitzer
eBook ISBN: 9780323143301
Imprint: Academic Press
Published Date: 1st January 1966
Page Count: 694
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Experimental Chemotherapy, Volume IV: Chemotherapy of Neoplastic Diseases, Part I focuses on the use of chemotherapy to counteract neoplastic ailments. The book first discusses the chemotherapy of neoplastic diseases, and this includes approaches to cancer chemotherapy, methods of drug evaluation, and the effects of antitumor antibiotics. The text also presents an appendix to the previous volumes. Toxicity and drug resistance in chemotherapy; chemotherapy of trypanosomiasis, giardiasis, and histomoniasis; and the use of antibiotics in chemotherapy are discussed. Experiments on the processes, methodologies, and medical interventions on the chemotherapy of these ailments are given importance. The book also identifies some antibiotics used in the chemotherapy of fungal and bacterial infections. These antibiotics include pimaricin, fucidin, gramicidin, lincomycin, and rifamycin SV. The book is a vital reference for readers wanting to explore the potential of chemotherapy on medical interventions on neoplastic diseases.

Table of Contents



Contents of Volume I

Contents of Volume II

Contents of Volume III

Contents of Volume V

Chemotherapy of Neoplastic Diseases I

1. Approaches to Cancer Chemotherapy



2. Methods of Drug Evaluation

I. Introduction

II. Screening Systems in Cancer Chemotherapy

III. Design of Screening Procedures

IV. Design of Comparative Investigations

V. Mechanism of Drug Action

VI. Toxicological Investigations


3. Antimetabolites

I. Introduction

II. Aminopterin and Related Compounds

III. Some Other Folic Acid Antagonists

IV. 6-Mercaptopurine

V. 6-Thioguanine

VI. Some Other Substituted Purines, with Particular Reference to Derivatives of 6-Mercaptopurine and 6-Thioguanine

VII. 8-Azaguanine

VIII. 5-Fluoropyrimidines and Their Ribosides

IX. Iodo- and Bromopyrimidine Deoxyribosides

X. 6-Azauracil and 6-Azauridine

XI. Some Other Pyrimidine Derivatives and Analogs

XII. 1-Aminocyclopentanecarboxylic Acid (ACP)

XIII. Other Amino Acid Analogs


4. Antitumor Antibiotics

I. Introduction

II. The Actinomycins

III. Mitomycin C

IV. Azaserine

V. DON (6-Diazo-5-oxo-L-norleucine)

VI. Puromycin

VII. Sarkomycin

VIII. Cycloheximide, E73, and the Streptovitacins

IX. Carzinophilin

X. Chromomycin A3 (Toyomycin)

XI. Antibiotic 6270

XII. Streptonigrin

XIII. Fumagillin and Fumagillin Alcohol

XIV. Psicofuranine

XV. Hadacidin

XVI. Actinogan and Peptinogan

XVII. Miscellaneous Antibiotics


Appendix: Survey of Recent Developments in Experimental Chemotherapy: Supplements to Volumes I, II, and III

Supplement to Volume I

Toxicity in Chemotherapy

Statistical Evaluation in Chemotherapy

Drug Resistance in Chemotherapy

Chemotherapy of Trypanosomiasis

Chemotherapy of Trichomoniasis

Chemotherapy of Histomoniasis

Chemotherapy of Giardiasis

Chemotherapy of Amebiasis

Chemotherapy of Coccidiosis

Chemotherapy of Malaria. Part 2. The Antimalarial Drugs

Chemotherapy of Babesiasis

Chemotherapy of Theileriasis and Anaplasmosis

Chemotherapy of Toxoplasmosis

Chemotherapy of Balantidiasis

Chemotherapy of Spirochetal Infections

Chemotherapy of Miscellaneous Infections

Chemotherapy of Filariasis

Chemotherapy of Myiasis

Supplement to Volume II

Chemotherapy with Antibacterial Dyestuffs

Acridine Dye Action at Cellular and Molecular Levels

Microbial Resistance to Harsh and Destructive Environmental Conditions

Antibacterial Chemotherapy with Sulfonamides

The Nitrofurans—Chemotherapeutic Properties

Antibacterial Agents of Limited Action

Experimental Chemotherapy of Leprosy

Supplement to Volume III

The Tetracyclines

The Macrolides (Erythromycin Group)

The Polypeptides of the Polymyxin Group


Antibiotics Used in the Chemotherapy of Bacterial and Fungal Infections

Chemotherapy of Rickettsial Infections

Experiences with Experimental Chemotherapy of Viral Diseases

Bibliographic List of Recent Publications Not Discussed in This Supplement

Author Index

Subject Index


No. of pages:
© Academic Press 1966
1st January 1966
Academic Press
eBook ISBN:

About the Editor

R Schnitzer

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