Experimental and Comparative Toxicology

Experimental and Comparative Toxicology

1st Edition - May 7, 1987

Write a review

  • Editors: Charles E. Cornelius, Charles F. Simpson
  • eBook ISBN: 9781483215792

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Experimental and Comparative Toxicology, Volume 31 aims to explore some of the potentially important and crucial areas in experimental toxicology. The book discusses tumor promoters and genotoxic chemicals in short-term testing for carcinogenicity, as well as the significance of preneoplastic liver lesions in experimental animals. The text also describes the factors known to be associated with increased risk of liver neoplasia as a human disease, and the extent to which it is known that the same factors have a similar effect in laboratory animals. Neurobehavioral toxicology; immunotoxicology; and the endocrine system as the target in experimental toxicology are also considered. The book further tackles the uses of gamma-glutamyltransferase in experimental toxicology, as well as the predictive value of ocular irritation tests. Toxicologists, biochemists, pathologists, and those involved in preventive medicine and community health will find the text invaluable.

Table of Contents

  • Preface

    Tumor Promotors and Genotoxic Chemicals in Short-Term Testing for Carcinogenicity

    I. Introduction

    II. Complete and "Incomplete" Carcinogens

    III. Acute and Chronic Toxicity

    IV. New Testing Strategies

    V. Conclusions


    The Significance of Preneoplastic Liver Lesions in Experimental Animals

    I. Introduction

    II. Significance of Preneoplastic Lesions

    III. Characteristics of Altered Foci

    IV. Induction of Altered Foci as a Means of Detecting Carcinogens

    V. Enhancement of Altered Foci as a Means of Identifying Neoplasm-Promoting Agents

    VI. Inhibition of Altered Foci as a Means of Identifying Anticarcinogens

    VII. Conclusions


    Liver Tumors in Rodents: Extrapolation to Man

    I. Introduction

    II. Different Kinds of Liver Tumors

    III. Etiological Factors for Hepatic Neoplasia in Man and the Availability of Animal Models

    IV. Mortality from Primary Liver Cancer in England and Wales

    V. Factors Other Than Test Chemicals Which Influence the Risk of Hepatic Neoplasia in Laboratory Rodents

    VI. The Significance of Enzyme-Altered Foci in the Pathogenesis of Hepatocellular Neoplasia

    VII. The Prediction of Hepatocarcinogenic Risk for Man

    VIII. Summary


    Neurobehavioral Toxicology: An Overview

    I. Introduction

    II. Neurobehavioral Toxicology: A Historical Perspective

    III. Methods in Neurobehavioral Toxicology

    IV. Corroborating Tests

    V. Neurobehavioral Assessment of Neurotoxins: Past and Present

    VI. Topics for Future Research



    I. Introduction

    II. Brief Anatomical and Physiological Considerations

    III. Proposed Models for Immunotoxicity Assessment

    IV. Conclusion


    The Endocrine System as the Target in Experimental Toxicology

    I. Introduction

    II. No-Hormonal-Effect Level

    III. Practical Considerations

    IV. Applied Techniques

    V. Experimental Practice


    Uses of γ-Glutamyltransferase in Experimental Toxicology

    I. Introduction

    II. Distribution of the Enzyme

    III. Hepatic Induction and Hepatic Disturbances

    IV. GGT and Experimental Carcinogenesis

    V. Urine GGT in Experimental Kidney Toxicity

    VI. Conclusion


    Predictive Value of Ocular Irritation Tests

    I. Introduction

    II. Tests Presently Used

    III. Are Tests Presently Used Predictive?

    IV. Can We Improve the Predictivity of the Tests?

    V. Can We Develop Alternative Methods to the Use of Animals?

    VI. Conclusions



Product details

  • No. of pages: 218
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: May 7, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483215792

About the Editors

Charles E. Cornelius

Charles F. Simpson

Ratings and Reviews

Write a review

There are currently no reviews for "Experimental and Comparative Toxicology"