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Evolutionary Diversity as a Source for Anticancer Molecules - 1st Edition - ISBN: 9780128217108

Evolutionary Diversity as a Source for Anticancer Molecules

1st Edition

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Editors: Akhileshwar Kumar Srivastava Vinod Kumar Kannaujiya Rajesh Kumar Singh Divya Singh
Paperback ISBN: 9780128217108
Imprint: Academic Press
Published Date: 30th September 2020
Page Count: 390
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Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products
derived from invertebrates that can be used as part of cancer treatment.

Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients.
This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical
field interested in understanding more about natural products with anticancer potential.

Key Features

  • Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment
  • Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites


Cancer researchers, bioinformaticians, molecular biologists, medicinal chemists, pharmacists

Table of Contents


1. Evolutionary mechanism for biosynthesis of diverse molecules
1.1 Introduction
1.2 Models for evolutionary study
1.3 Evolution of secondary metabolite pathways
1.4 Cell fitness coupling for natural metabolite production
1.5 Chemical diversity of natural products
1.6 Occurrence of flavonoids in the plant kingdom
1.7 Biomolecular activity of secondary metabolites
1.8 Evolution of anticancer drug discovery
1.9 Factors influence the production of secondary metabolites
1.10 Future prospective

2. Impact of ploidy changes on secondary metabolites productions in plants
2.1 An introduction to ploids (or polyploids)
2.2 Morphological effects, meiotic and breeding behavior
2.3 Role of ploids (auto, allo and induced) in secondary metabolites production
2.4 Perspectives

3. Effect of climate change on plant secondary metabolism: An ecological perspective
3.1 Introduction
3.2 Evolutionary theory based on secondary metabolites
3.3 Effect of climate change on secondary metabolites
3.4 Impact of climate change on secondary metabolites of medicinal plants
3.5 The expression of secondary compounds in plants
3.6 Early stage of plant evolution
3.7 Environmental factors triggering the secondary metabolism
3.8 The regulation of plant secondary metabolism by interactions of heat shock and elevated CO2
3.9 Ecological roles of secondary metabolites
3.10 The ecosystem feedback of plant secondary metabolites for the climate change
3.11 Secondary metabolites as worthy asset for the biological system: Further support
3.12 Conclusions and future prospective

4. Isolation and characterization of bioactive compounds from
natural resources: Metabolomics and molecular approaches
4.1 Introduction
4.2 Metabolomics approach
4.3 Metabolomics technologies
4.4 Molecular approach
4.5 Conclusion and future perspectives

5. Single-celled bacteria as tool for cancer therapy
5.1 Introduction
5.2 The anti-tumor effect through the release of bacterial substances
5.3 The anti-tumor effect through enhancement of human immunity
5.4 The anti-tumor effect through the production of biofilms
5.5 The anti-tumor effect through the use of viruses along with bacteria
5.6 The anti-tumor effect through bacteria-mediated anti-angiogenesis therapy
5.7 The anti-tumor effect through live tumor-targeting bacteria
5.8 The anti-tumor effect through the use of live bacteria as a tumor suppressor
5.9 The anti-tumor activity through the use of engineered bacteria
5.10 The anti-tumor activity of bacteria in combination with radiotherapy
5.11 The anti-tumor activity of bacteria through tumor-specific antigens and antibodies
5.12 The anti-tumor activity of bacteria through gene transfer
5.13 The anti-tumor activity of bacteria through gene silencing
5.14 The anti-tumor activity of bacteria through gene triggering strategies
5.15 Future prospective

6. Metabolic pathways for production of anticancer compounds in cyanobacteria
6.1 Introduction
6.2 Diversity and evolutionary significance of cyanobacteria
6.3 Exploration of secondary metabolites
6.4 Structural and functional diversity of anticancerous metabolites
6.5 Biosynthetic pathway
6.6 Future perspectives
6.7 Conclusion

7. Prophyletic origin of algae as potential repository of anticancer compounds
7.1 Introduction
7.2 Metabolites or bioactive substances present in marine algae having anticancer properties
7.3 Anticancer therapy via apoptosis
7.4 Death receptor mediated pathway or extrinsic pathway
7.5 Other: A typical forms of cell death
7.6 Anticancer compound isolated from marine algae
7.7 Anticancer properties of reported marine algal family
7.8 Conclusions
Further reading

8. Metabolic versatility of fungi as a source for anticancer compounds
8.1 Introduction
8.2 Plant-fungal interactions and its metabolic diversity
8.3 Genetic aspects of plant-fungal interactions
8.4 Biochemical aspects of plant-fungal interactions
8.5 Signal transduction pathway in plant-fungal interactions
8.6 The potent anticancer compounds produced by terrestrial endophytic fungi
8.7 The potent anticancer compounds produced by deep-sea sediment fungi
8.8 The potent anticancer compounds produced by algaeassociated fungi
8.9 The potent anticancer compounds produced by mangrove endophytic fungi
8.10 The potent anticancer compounds produced by sponge associated fungi
8.11 Conclusion

9. Structural information of natural product metabolites in bryophytes
9.1 Introduction
9.2 Exploration of bryophytes for medicinal usage
9.3 Bryophytes as a source of biologically active molecules
9.4 Different types of secondary metabolites found in bryophytes
9.5 Bioactive molecules from bryophytes reported with different pharmacological activities
9.6 Bryophytes as a potential biopharming agents
9.7 Chemical syntheses of bryophyte components
9.8 Biotechnological applications for effective utilization of bryophytes for therapy
9.9 Challenges and future prospects
9.10 Conclusion

10. Landscape of natural product diversity in land-plants as source for anticancer molecules
10.1 Introduction
10.2 Plant diversity and their anticancer potential
10.3 Microbial antitumor products
10.4 Anticancer property of fungi
10.5 Responses of cancer cells to the lichen compounds
10.6 Therapeutic potential of bryophytes against cancer
10.7 Ferns a treasury of anticancer agents
10.8 Anticancer property of gymnosperm
10.9 Anticancer potential of angiosperms
10.10 Conclusion

11. Anticancer natural product from marine invertebrates
11.1 Introduction
11.2 Sponges
11.3 Cnidaria
11.4 Bryozoa
11.5 Molluscs
11.6 Echinoderms
11.7 Conclusions
Further reading

12. Melatonin: A scientific journey from the discovery in bovine pineal gland to a promising oncostatic agent: An evolutionary perspective
12.1 Introduction
12.2 Evolutionary history of melatonin
12.3 Synthesis of melatonin in animals
12.4 Synthesis of melatonin in plants
12.5 Role of melatonin in integrity of genome and DNA repair
12.6 Melatonin and telomerase activity
12.7 Conclusion
12.8 Challenge and future perspective

13. Spice up your food for cancer prevention: Cancer chemo-prevention by natural compounds from common dietary spices
13.1 Introduction
13.2 Role of diet in cancer origin and progression
13.3 Anticancer activities of select spices used in daily diet
13.4 Concluding summary

14. Significance of nutraceuticals in cancer therapy
14.1 History of nutraceuticals
14.2 Drawbacks in conventional cancer treatments
14.3 Importance of nutraceuticals in cancer therapy
14.4 Various nutraceuticals and their application in cancer therapy
14.5 Conclusion and future prospective

15. Common techniques and methods for screening of natural products for developing of anticancer drugs
15.1 Introduction
15.2 Extraction of compounds
15.3 Fractionation
15.4 Purification
15.5 Crystallization
15.6 Chromatography
15.7 Physical methods for basic structure elucidation
15.8 Antioxidant assay
15.9 Single electron transfer
15.10 Hydrogen atom and single electron transfer
15.11 Chelation power of antioxidant
15.12 Lipid oxidation
15.13 Anticancer assay
15.14 Methods to detect ROS
15.15 Conclusion



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© Academic Press 2021
30th September 2020
Academic Press
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About the Editors

Akhileshwar Kumar Srivastava

Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) in CSIR-Central Food Technological Research Institute, Mysore, India. In his eight years of research, he has published more than 16 research articles and book chapters in international and national journals of repute. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology-associated targeting cancer diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, United States on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in Indian Science Congress and Agriculture, Nutrition and Health Academy, United Kingdom.

Affiliations and Expertise

Research Associate (ICMR), CSIR-Central Food Technological Research Institute, Mysore, India

Vinod Kumar Kannaujiya

Dr. Vinod Kumar Kannaujiya is an assistant professor in the Department of Botany, MMV, Banaras Hindu University, India. He earned MSc and PhD degrees in Botany from the Centre of Advanced Study in Botany, Banaras Hindu University. He has been working on the ultraviolet stress response of cyanobacteria including value-added enzymes, proteins, pigments, and natural compounds. He has been awarded with prestigious fellowships from the Council of Scientific and Industrial Research, New Delhi, India. He has also been awarded the Dr. D.S. Kothari Post-Doctoral Fellowship from University Grant Commission, New Delhi, India, and he has received a UGC-Startup project grant from UGC, New Delhi, India. Dr. Kannaujiya is a life member fellow of the Indian Photobiology Society. Thus far, Dr. Kannaujiya has published over 40 original research papers, reviews, and book chapters.

Affiliations and Expertise

Assistant professor, Department of Botany, MMV, Banaras Hindu University, India. MSc and PhD degrees, Botany from the Centre of Advanced Study in Botany, Banaras Hindu University

Rajesh Kumar Singh

Dr. Rajesh Kumar Singh is currently working as a Research Associate in Banaras Hindu University. His research focus is pharmacognosy, reverse pharmacology, drug design and discovery, extraction & isolation of natural products, cell culture, and handling of different rodents. He has published several research articles in reputable journals over the course of his career. At present, he is involved in developing an Indian origin cell line and screening drugs of natural origin for the treatment of gallbladder cancer.

Affiliations and Expertise

Research associate, Centre of Experimental Medicine & Surgery at Banaras Hindu University.

Divya Singh

Dr. Divya Singh is presently working as a scientist in Central Sericultural Research and Training Institute, Mysore, India. Her research specialization is primarily in genetics, proteomics, metabolomics, toxicology, bioinformatics, and molecular biological evaluation in various in vivo and in vitro plant models to elucidate the physiological changes and evaluate the DNA damage potency. She has published more than 10 research articles including book chapters. In addition, she is also a life member fellow of Indian Science Congress.

Affiliations and Expertise

Scientist, Central Sericultural Research and Training Institute, Mysore, India

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