- Electronic ISBN 9780128004982
- Print ISBN 9780128001653
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution.
Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution.
This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology.
biologists, medical students and doctors, specializing in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology.
Chapter 1. The Modern Synthesis of Evolutionary Biology and the Health Sciences
Chapter 2. Evolution and Pathology
2.1 Pathogens and Pathologies May Have Adaptive and/or Evolutionary Importance
2.2 Evolution vs. Pathology Paradox of Mutations
Chapter 3. The Widespread Occurrence of Tumors in Multicellular Organisms
3.1 Comparative Oncological Data on the Prevalence of Tumors in Different Groups of Multicellular Organisms
3.2 Ancient Origin and Conservatism of Cellular Oncogenes and Tumor Suppressor Genes
3.3 The Widespread Occurrence of Tumors Suggests that they May Be Evolutionarily Meaningful
Chapter 4. Features of Tumors that Could Be Used in Evolution
4.1 Unusual Genes and Gene Sets are Activated in Tumors and May Participate in the Origin of New Cell Types
4.2 Tumor Cells Can Differentiate with the Loss of Malignancy that May Lead to the Origin of New Cell Types
4.3 Tumors Provide Excessive Cell Masses Functionally Unnecessary to the Organism that Could be Used for the Origin of New Cell Types, Tissues and Organs
4.4 Tumors as Atypical Organs/Tissues that May Eventually Evolve into Normal Structures
Chapter 5. Tumors Might Participate in the Evolution of Ontogenesis
5.1 Tumors and Normal Embryogenesis
5.2 Tumors as Disease of Differentiation
5.3 The Epithelial to Mesenchymal Transition (EMT) Occurs in Normal and Neoplastic Development
5.4 Tumors, Evo-Devo and Addition of Final Stages in the Evolution of Ontogenesis
5.5 The Human Brain, as the Most Recently Evolved Organ, Recapitulates Many Features Resembling those of Tumors
5.6 The Eutherian Placenta is Evolutionary Innovation and Recapitulates Many Tumor Features
Chapter 6. Tumors that Might Play a Role in Evolution
6.1 Hereditary Tumors
6.2 Fetal, Neonatal and Infantil
"...an excellent book that formulates the hypothesis of evolution by tumor neofunctionalization and presents interesting concepts related to the positive role of tumors in the evolution of multicellular organisms. It will be of immense interest to a diverse group of professionals...3 Stars - Score: 86" -Doody's.com, Nov 14, 2014