Eukaryotic Transcription Factors

Eukaryotic Transcription Factors

5th Edition - September 12, 2007

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  • Author: David Latchman
  • eBook ISBN: 9780080561035
  • Hardcover ISBN: 9780123739834

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Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.

Key Features

  • Potential of transcription factors as therapeutic targets in human disease
  • Importance of histone modifications
  • Use of genome-based sequence analysis and high-throughput methods
  • Applications of the chromatin immunoprecipitation (ChIP) assay
  • Transcriptional elongation
  • Regulation by post-translational modifications
  • Regulatory networks and bioinformatics


A mandatory resource for any researcher or student in the life sciences

Table of Contents

  • DNA sequences, transcription factors and chromatin structure
    Methods for studying transcription factors
    RNA polymerases and the basal transcriptional complex
    Families of DNA binding transcription factors
    Activation of gene expression by transcription factors
    Repression of gene expression by transcription factors
    Regulation of transcription factor synthesis
    Regulation of transcription factor activity
    Transcription factors and human disease

Product details

  • No. of pages: 488
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: September 12, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080561035
  • Hardcover ISBN: 9780123739834

About the Author

David Latchman

Affiliations and Expertise

Master of Birkbeck, University of London, Professor of Genetics, Birkbeck and University College London, UK

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