Eukaryotic RNases and Their Partners in RNA Degradation and Biogenesis, Volume 31

1st Edition

Part A

Serial Volume Editors: Guillaume Chanfreau Fuyuhiko Tamanoi
Hardcover ISBN: 9780124047402
eBook ISBN: 9780124047457
Imprint: Academic Press
Published Date: 16th October 2012
Page Count: 278
117.00 + applicable tax
94.00 + applicable tax
155.00 + applicable tax
Unavailable
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


Table of Contents

Preface

Chapter One. Biochemistry and Function of RNA Exosomes

1. Introduction

2. Cellular Functions of the Exosome

3. Composition of Exosomes and Their Related Complexes

4. Exosome Cofactors

5. Concluding Remarks

References

Chapter Two. Plant Exosomes and Cofactors

1. Introduction

2. Composition of the Plant Exosome Core Complex

3. Exosome-Related Activities and Cofactors in Plants

4. Impact of Exosome-Mediated Degradation in Plants

5. Final Remarks

References

Chapter Three. Structure and Activities of the Eukaryotic RNA Exosome

1. Introduction

2. Global Architecture of the Eukaryotic Exosome Core

3. RNase PH-Like Domains Comprise a PH-Like Ring in Eukaryotic Exosomes

4. S1 and KH Domains Cap the PH-Like Ring

5. RRP44, a Hydrolytic Endoribonuclease and Processive Exoribonuclease

6. RRP44 and the 10-Component Exosome

7. RRP6, a Eukaryotic Exosome Subunit with Distributive Hydrolytic Activities

8. RRP44, RRP6, and the 11-Component Nuclear Exosome

9. Conclusions

References

Chapter Four. TRAMP Stimulation of Exosome

1. TRAMP Is a Cofactor of Nuclear Exosome

2. RNA Substrate Repertoire of TRAMP

3. TRAMP Biochemistry and Structure

4. TRAMP Complex in Activation of the Exosome

5. TRAMP Complexes in Different Organisms

References

Chapter Five. XRN1: A Major 5′ to 3′ Exoribonuclease in Eukaryotic Cells

1. Introduction

2. XRN1 in mRNA Decay

3. XRN1 in mRNA Quality Control

4. XRN1 in miRNA-Mediated Decay

5. XRN1 in siRNA-Mediated Decay

6. Localization of XRN1 in Cells

7. XRN1 in lncRNA Decay

8. XRN1 in tRNA Quality Control

9. XRN1 in rRNA and snoRNA Processing

10. Regulation of XRN1 Activity

11. Summary

Refe


Description

This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer


Details

No. of pages:
278
Language:
English
Copyright:
© Academic Press 2012
Published:
Imprint:
Academic Press
eBook ISBN:
9780124047457
Hardcover ISBN:
9780124047402

About the Serial Volume Editors

Guillaume Chanfreau Serial Volume Editor

Dr Guillaume Chanfreau obtained his Bachelor Degree from Université Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Université Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3’-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression.

Affiliations and Expertise

UCLA

Fuyuhiko Tamanoi Serial Volume Editor

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.

Affiliations and Expertise

University of California, Los Angeles, USA