Essentials of Genomic and Personalized Medicine

1st Edition

Editors: Geoffrey Ginsburg Huntington Willard
Hardcover ISBN: 9780123749345
eBook ISBN: 9780080958118
Imprint: Academic Press
Published Date: 24th September 2009
Page Count: 850
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Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine.

Key Features

  • Full color throughout
  • Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field
  • Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice
  • Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science


general practitioners, specialists, and students across medical disciplines, research professionals in human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and related areas

Table of Contents

1 Introduction

 Section 1 - Basics
2 Organization, Variation and Expression of the Human Genome
3 DNA Sequencing for the Detection  of Human Genome Variation
4 Genome-Wide Association Studies and Genotyping Technologies
5 Copy Number Variation and Human Health
6 DNA Methylation Analysis: Providing New Insight into Human Disease
7 DNA Microarrays in Biological Diversity and Patient Care
8 Proteomics: The Deciphering of the Functional Genome
9 Comprehensive Metabolic Analysis for Understanding Disease

 Section 2 - Informatics
10 Bioinformatic and Computational Analysis for Genomic Medicine
11 Systems Biology and Systems Medicine
12 Electronic Medical Records in Genomic Medicine Practice and Research
13 Health Information Retrieval for Consumers

 Section 3 - Translational
14 Genomics to Health:  Challenges and Opportunities
15 Pharmacogenetics and Pharmacogenomics
16 Clinical Implementation of Translational Genomics
17 The Role of Genomics in Enabling Prospective Health
18 From Sequence to Genomic Medicine: Genome Policy Considerations
19 Federal Regulation of Genomic Medicine
20 Economic Issues and Genomic Medicine
21 Public Health Genomics

 Section 4 - Clinical (Cardiology)
22 Hypertension
23 Lipiprotein Disorders
24 Myocardial Infarction
25 Acute Coronary Syndromes
26 Heart Failure in the Era of Genomic Medicine
27 Genomic Assessment of Cardiac Transplant Rejection
28 Hypertrophic Cardiomyopathy
29 Arrhythmias
30 Genetics and Genomics in the Management of Hemostasis & Thrombosis
31 Genomics of Congenital Heart Disease

 Section 5 - Clinical (Oncology)


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© Academic Press 2010
Academic Press
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About the Editor

Geoffrey Ginsburg

Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.

Affiliations and Expertise

Institute for Genome Sciences & Policy, Duke University, Durham, NC, USA

Huntington Willard

Huntington Willard is President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. Prior to his appointment at the MBL, Willard was on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.

Affiliations and Expertise

President and Director, The Marine Biological Laboratory, Woods Hole, Massachusetts, and Professor of Human Genetics, University of Chicago, Chicago, IL, USA