Essentials of 3D Biofabrication and Translation
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Essentials of 3D Biofabrication and Translation

1st Edition - July 17, 2015

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  • Authors: Anthony Atala, James Yoo
  • Hardcover ISBN: 9780128009727
  • eBook ISBN: 9780128010150

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Description

Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine.

Key Features

  • Provides a new and versatile method to fabricating living tissue
  • Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction
  • Describes current approaches and future challenges for translational science
  • Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Readership

biomedical and bioengineering researchers working in different phases of the development of regenerative medicine tools including cell banking, stem cells and cell therapy, biomaterials, and tissue engineering; and scientific administrators and grad students in biotechnology fields

Table of Contents

    • Dedication
    • List of Contributors
    • Preface
    • Chapter 1: Bioprinting Essentials of Cell and Protein Viability
      • Abstract
      • 1. An introduction to bioprinting
      • 2. Cell sourcing
      • 3. Biomaterials and bioinks
      • 4. Integration with biofabrication devices
      • 5. Maintenance and maturation of constructs
      • 6. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 2: Software for Biofabrication
      • Abstract
      • 1. Introduction
      • 2. Concepts of medical image-based research and engineering
      • 3. “Bioprinting” means many things in 3D printing
      • 4. Bioprinting and conventional 3D printing require similar workflows and tools
      • 5. A software review
      • 6. Medical image-based research and engineering
      • 7. Creation of complex scaffolding or porous structures
      • 8. Preparation and optimization – from the final design to the printed object
      • 9. Management of a multiple-printer facility
      • 10. Examples of bioprinting applications benefiting from additive manufacturing software
      • 11. Conclusions
      • Abbreviations
    • Chapter 3: Design and Quality Control for Translating 3D-Printed Scaffolds
      • Abstract
      • 1. Introduction
      • 2. Splint design control
      • 3. Laser sintering PCL splints
      • 4. Splint design verification
      • 5. Design validation – preclinical model results
      • 6. Design validation – clinical results
      • 7. The future of 3D laser-sintered PCL devices
      • Glossary
      • Abbreviations
    • Chapter 4: Inkjet Bioprinting
      • Abstract
      • 1. Introduction
      • 2. The advent of new era – biofabrication of tissues and organs
      • 3. Inkjet bioprinting technology for tissue engineering
      • 4. Inkjet bioprinting technology for pharmaceutical applications
      • 5. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 5: In Vivo and In Situ Biofabrication by Laser-Assisted Bioprinting
      • Abstract
      • 1. Merging computer-assisted surgery and biofabrication
      • 2. Customized bioprinting system for in vivo and in situ interventions
      • 3. Procedure for in vivo and in situ bioprinting into bone calvarial defects
      • 4. Proof of concept of in vivo and in situ bioprinting
      • 5. From in vitro to in vivo and in situ biofabrication
      • 6. Conclusions
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 6: Stereolithographic 3D Bioprinting for Biomedical Applications
      • Abstract
      • 1. Introduction
      • 2. The stereolithographic process
      • 3. Applications of stereolithography in surgical procedures, prostheses, and implants
      • 4. Applications of stereolithography in tissue engineering and regenerative medicine
      • 5. Conclusions
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 7: Extrusion Bioprinting
      • Abstract
      • 1. Introduction
      • 2. Extrusion-based bioprinting system
      • 3. Biofabrication strategies
      • 4. Future directions
      • 5. Conclusions
      • Glossary
      • Abbreviations
      • Acknowledgment
    • Chapter 8: Indirect Rapid Prototyping for Tissue Engineering
      • Abstract
      • 1. Introduction
      • 2. RP technologies
      • 3. Indirect rapid prototyping
      • 4. Solidification of liquid materials
      • 5. Generation from the solid phase
      • 6. iRP2
      • 7. Discussion and conclusions
      • Glossary
      • Abbreviations
    • Chapter 9: Bioprinting Using Aqueous Two-Phase System
      • Abstract
      • 1. Brief introduction to ATPS
      • 2. Additive printing using ATPS
      • 3. Subtractive printing using ATPS
      • 4. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 10: Bioprinting of Organs for Toxicology Testing
      • Abstract
      • 1. Introduction
      • 2. Bioprinting technologies for organoid construction
      • 3. Bioprinted organoids
      • 4. Conclusions and future perspectives
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 11: High Throughput Screening with Biofabrication Platforms
      • Abstract
      • 1. Outline
      • 2. Two-dimensional and three-dimensional HTS
      • 3. High-content screening
      • 4. Bioprinting technologies
      • 5. HTS platforms
      • 6. HTS and organ bioprinting
      • 7. Data acquisition treatment and analysis
      • 8. Conclusions and Future Perspectives
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 12: Biosensor and Bioprinting
      • Abstract
      • 1. Introduction
      • 2. Sensors
      • 3. Sensor technology for translational research on regenerative therapy
      • 4. Bioprinting technology for advances of biosensor
      • 5. Microprinting and patterning of living biosensor application
      • 6. Future perspectives
      • Glossary
      • Abbreviations
    • Chapter 13: Polymers for Bioprinting
      • Abstract
      • 1. Introduction
      • 2. Polymer properties for bioprinting
      • 3. Natural polymers for bioprinting
      • 4. Synthetic polymers
      • 5. Summary
      • 6. Polymer hybrids
      • 7. Emerging trends and future directions
      • 8. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 14: Hydrogels for 3D Bioprinting Applications
      • Abstract
      • 1. Introduction
      • 2. General principles
      • 3. Commonly used hydrogels
      • 4. Conclusions and future outlook
      • Glossary
      • Abbreviations
    • Chapter 15: Bioprinting of Organoids
      • Abstract
      • 1. Introduction
      • 2. Strategy of bioprinting technology for producing organoid structures
      • 3. Bioprinting modalities
      • 4. Bioinks for organoid printing
      • 5. Summary and future directions
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 16: Bioprinting of Three-Dimensional Tissues and Organ Constructs
      • Abstract
      • 1. Introduction
      • 2. Three-dimensional bioprinting technology
      • 3. Anatomically shaped 3D constructs
      • 4. Applications of bioprinting
      • 5. Current limitations and future perspectives
      • 6. Summary
      • Glossary
      • Abbreviations
    • Chapter 17: Bioprinting of Bone
      • Abstract
      • 1. Introduction
      • 2. Clinical need for bone graft and bone substitute
      • 3. Bone biology
      • 4. Wound healing
      • 5. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 18: Bioprinting of Cartilage: Recent Progress on Bioprinting of Cartilage
      • Abstract
      • 1. Introduction
      • 2. Blueprint for bioprinting of cartilage
      • 3. Cell source for bioprinting of cartilage
      • 4. Materials for bioprinting of cartilage
      • 5. Other parameters include the stimulating factors and bioreactors
      • 6. Preclinical animal models for safety and efficacy evaluation of bioprinted cartilage
      • 7. Developing areas and future directions
      • Glossary
      • Abbreviations
    • Chapter 19: Biofabrication of Vascular Networks
      • Abstract
      • 1. Introduction
      • 2. The vasculature
      • 3. Vascular Form and Function
      • 4. Vascular networks
      • 5. Vascular fabrication
      • 6. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 20: Bioprinting of Blood Vessels
      • Abstract
      • 1. Introduction
      • 2. Blood vessel composition
      • 3. Challenges associated with vessel bioprinting
      • 4. Direct vessel bioprinting
      • 5. Hybrid vessel and graft fabrication
      • 6. Casting
      • 7. Strategies for indirect microvessel infiltration
      • 8. Postprinting
      • 9. Conclusions and future trends
      • Glossary
      • Abbreviations
      • Acknowledgments
    • Chapter 21: Bioprinting of Cardiac Tissues
      • Abstract
      • 1. Introduction
      • 2. Brief overview of heart anatomy and physiology
      • 3. Prevalence and severity of heart disease and defects
      • 4. Current clinical treatments for heart disease
      • 5. Engineering design criteria for tissue-engineered heart valves
      • 6. State-of-the-art approaches for cardiac tissue regeneration
      • 7. Strategies for heart valve tissue engineering
      • 8. Bioprinting of Myocardial Tissue
      • 9. 3D printing of tissue-engineered heart valves
      • 10. Potential cell source for 3D printing
      • 11. Conclusions and future direction
      • Glossary
      • Abbreviations
    • Chapter 22: Bioprinting of Skin
      • Abstract
      • 1. Introduction
      • 2. Structure of the skin
      • 3. Wound healing
      • 4. Treatment methods for skin repair
      • 5. Skin bioprinting
      • 6. Conclusions
      • Abbreviation
    • Chapter 23: Bioprinting of Nerve
      • Abstract
      • 1. Introduction
      • 2. Bioprinting based on biological self-assembly
      • 3. Bioprinting tubular structures
      • 4. Biofabrication of a nerve graft
      • 5. Conclusions
      • Glossary
      • Abbreviations
    • Chapter 24: Bioprinting: An Industrial Perspective
      • Abstract
      • 1. Introduction
      • 2. The role of 3D fabrication in the healthcare industry
      • 3. Commercial opportunities for 3D biofabrication
      • 4. Summary
      • Glossary
      • Abbreviations
    • Subject Index

Product details

  • No. of pages: 440
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: July 17, 2015
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128009727
  • eBook ISBN: 9780128010150

About the Authors

Anthony Atala

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

Affiliations and Expertise

Professor, Wake Forest Institute for Regenerative Medicine

James Yoo

Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

Affiliations and Expertise

Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

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