Essential Pharmacokinetics

Essential Pharmacokinetics

A Primer for Pharmaceutical Scientists

1st Edition - March 25, 2015

Write a review

  • Author: Thorsteinn Loftsson
  • eBook ISBN: 9780128014912

Purchase options

Purchase options
DRM-free (EPub, Mobi, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences.  This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource.  Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more.  Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

Key Features

  • Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products
  • Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes
  • Illustrates how to write and evaluate drug registration files

Readership

Intended for graduate students and pharmaceutical scientists involved in self-study of the topic or tutored classes in pharmacokinetics, specifically those in non-clinical health-related sciences such as pharmaceutics, drug formulation and medicinal chemistry.

Table of Contents

    • Dedication
    • Preface
    • Chapter 1. Introduction
      • 1.1 Some Basic Concepts
      • 1.2 Pharmacokinetic Models
      • 1.3 Population Pharmacokinetics
      • References
    • Chapter 2. Basic Concepts of Pharmacokinetics
      • 2.1 One-Compartment Open Model
      • 2.2 Two-Compartment Open Model
      • 2.3 Three-Compartment Open Model
      • 2.4 Pharmacokinetics of Drug Absorption
      • 2.5 Bioavailability
      • 2.6 Drug Distribution, Protein Binding, and Clearance
      • 2.7 Multiple-Dose Regimens
      • 2.8 Nonlinear Pharmacokinetics
      • 2.9 Drug Metabolism
      • 2.10 Drug Permeation Through Biomembranes and Drug Transporters
      • References
    • Chapter 3. Physicochemical Properties and Pharmacokinetics
      • 3.1 Lipinski’s Rule of Five
      • 3.2 The Biopharmaceutics Classification System
      • 3.3 The Biopharmaceutics Drug Disposition Classification System
      • 3.4 Metabolizability, Soft Drugs, and Prodrugs
      • 3.5 Pharmacokinetics of Excipients
      • References
    • Chapter 4. Drug Pharmacokinetics After Alternative Routes of Administration
      • 4.1 Fentanyl Transdermal Patch
      • 4.2 Estradiol Sublingual Tablets
      • 4.3 Diazepam Suppositories
      • 4.4 Midazolam Nasal Spray
      • 4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin
      • 4.6 Topical Delivery of Dexamethasone to the Eye
      • References
    • Chapter 5. Pharmacologic Response and Drug Dosage Adjustments
      • 5.1 Therapeutic Drug Monitoring
      • 5.2 Dosage Adjustments
      • 5.3 Pharmacodynamics
    • Chapter 6. The Effect of Food and Excipients on Drug Pharmacokinetics
      • References
    • Chapter 7. Practice Problems
      • 7.1
      • 7.2
      • 7.3
      • 7.4
      • 7.5
      • 7.6
      • 7.7
      • 7.8
      • 7.9
      • 7.10
      • 7.11
      • 7.12
      • 7.13
      • 7.14
      • 7.15
      • 7.16
      • 7.17
      • References
    • Appendix I. Answers to Problems in Chapter 7
      • 7.1
      • 7.2
      • 7.3
      • 7.4
      • 7.5
      • 7.6
      • 7.7
      • 7.8
      • 7.9
      • 7.10
      • 7.11
      • 7.12
      • 7.13
      • 7.14
      • 7.15
      • 7.16
      • 7.17
    • Appendix II. Symbols and Abbreviations
    • Index

Product details

  • No. of pages: 178
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: March 25, 2015
  • Imprint: Academic Press
  • eBook ISBN: 9780128014912

About the Author

Thorsteinn Loftsson

Dr. Thorsteinn Loftsson is a Professor of Physical Pharmacy at the University of Iceland in Reykjavik. He received his MS Pharm degree from University of Copenhagen and his MS and PhD degrees from the Department of Pharmaceutical Chemistry at the University of Kansas. Dr. Loftsson has authored or co-authors over 200 papers in peer-reviewed journals, numerous book chapters and 20 patents and patent applications. His main research areas include the pharmaceutical applications of cyclodextrins, marine lipids, prodrugs and soft drugs. He has conducted over 100 lectures and is a Fellow of the American Association of Pharmaceutical Scientists (AAPS). Dr. Loftsson is also a member for the editorial board of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Journal of Pharmacy and Pharmacology, die Pharmazie and Journal of Drug Delivery Science and Technology (formerly STP Pharma Sciences).

Affiliations and Expertise

MS Pharm, MSc, PhD, Faculty of Pharmaceutical Sciences, Professor of Physical Pharmacy, University of Iceland, Reykjavik, Iceland

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • Thu N. Mon Apr 06 2020

    essential pharmacokinetics

    This is a must have book.