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Essential Neuromodulation - 2nd Edition - ISBN: 9780128170007

Essential Neuromodulation

2nd Edition

Editors: Jeffrey Arle Jay Shils
Hardcover ISBN: 9780128170007
Imprint: Academic Press
Published Date: 1st September 2021
Page Count: 500
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Essential Neuromodulation, Second Edition is a concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuroscientists, residents, fellows, bioengineers and basic clinical practitioners. This second edition expands on developments in the field since 2011, emphasizing essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications and complication avoidance. As neuromodulation remains an exciting and rapidly advancing field, this information is critical for neurosurgeons, neurophysiologists, bioengineers and other proceduralists.

Key Features

  • Presents a comprehensive reference on the emerging field of neuromodulation that features chapters from leading physicians and researchers in the field
  • Provides a cohesive presentation of neuromodulation technologies and interventions
  • Contains 550 full-color pages that begin with an overview of the clinical phases involved in neuromodulation, the challenges facing therapies and intraoperative procedures, and innovative solutions for better patient care
  • Emphasizes the fundamentals needed to embrace the neuromodulation field as a cohesive clinical entity
  • Explores the use of electrical, chemical and mechanical interventions to heal and improve neurological deficits
  • Covers the promise of neurostimulation for chronic pain, epilepsy, Parkinson’s disease, and other disorders and diseases
  • Features developments in the field of neuromodulation since the first edition was published, including findings in lead, IPG and accessories


Neuroscientists, neurologists, neurosurgeons, neurophysiologists, anesthesiologists, and interventional neuroradiologists

Table of Contents


Part I: The Neuromodulation Approach
1. The Neuromodulation Approach
Jeffrey E. Arle

Part II: Regions of Application
2. Cerebral – Surface
Sergio Canavero
3. Cerebral – Deep
Yakov Gologorsky, Ron Alterman
4. Spinal – Extradural
Timothy R. Deer, S. Matthew Schocket
5. Peripheral Nerve
Konstantin V. Slavin
6. Imaging, frameless targeting and techniques
Abosch, Alterman

Part III: The Neuromodulation Therapy Interface
7. The Electrode – Materials and Configurations
Daniel R. Merrill
8. The Electrode – Principles of the Neural Interface
Cameron C. McIntyre
9. The Electrode – Principles of the Neural Interface
Erwin B. Montgomery Jr
10. Device Materials, Handling, and Upgradability
John Kast, Gabi Molnar, Mark Lent
11. Electronics
Emarit Ranu
12. Power
Tracy Cameron, Ben Tranchina, John Erickson
13. New waveforms – advantages and applications
Pope, Arle

Part IV: Placing Neuromodulation in the Human Body
14. Surgical Techniques
Jeffrey E. Arle
15. Trials and Their Applicability
Louis J. Raso
16. Limiting Morbidity
Konstantin V. Slavin
17. Intraoperative Physiology techniques to inform targeting
Falowski, Arle/Shils

Part V: Troubleshooting and Repair
18. Intraoperative Evaluation
Jay L. Shils, Jeffrey E. Arle

Part VI: Postoperative Management
19. Programming – DBS Programming
Jay L. Shils, Leo Verhagen
20. Programming – SCS
Gabi Molnar, Lisa Johanek, Steve Goetz, John Heitman
21. Safety Concerns and Limitations
Paul S. Larson, Alastair J. Martin

Part VII. The End User
19. Expectations and Outcomes
Guillermo A. Monsalve, Chad W. Farley, George T. Mandybur
20. Neuromodulation Perspectives
Kendal Lee - Alim Louis Benabid


No. of pages:
© Academic Press 2021
1st September 2021
Academic Press
Hardcover ISBN:

About the Editors

Jeffrey Arle

Jeffrey Arle

Jeff Arle, MD, PhD, FAANS

Dr. Arle is currently the Associate Chief of Neurosurgery at Beth Israel Deaconess Medical Center in Boston, the Chief of Neurosurgery at Mt. Auburn Hospital in Cambridge, and an Associate Professor of Neurosurgery at Harvard Medical School. He received his BA in Biopsychology from Columbia University in 1986 and his MD and PhD from the University of Connecticut in 1992. His dissertation work for his doctorate in Biomedical Sciences was in computational modeling in the Cochlear Nucleus. He then went on to do a residency in neurosurgery at the University of Pennsylvania, incorporating a double fellowship in movement disorder surgery and epilepsy surgery under Drs. Patrick Kelly, Ron Alterman, and Werner Doyle, finishing in 1999.

He edited the companion text Essential Neuromodulation with Dr. Shils, the first edition published by Elsevier in 2011. He has now practiced in the field of functional neurosurgery for 17 years and is experienced in all areas of neuromodulation from deep brain stimulators to vagus nerve, spinal cord, peripheral nerve, and motor cortex stimulators, contributing frequent peer-reviewed publications and numerous chapters to the literature on many aspects of the neuromodulation field. He currently serves as an associate editor at the journals Neuromodulation and Neurosurgery, is the co-chair of the Research and Scientific Policy Committee for the International Neuromodulation Society, and is on the Board of Directors for the International Society for Intraoperative Neurophysiology. His longstanding research interests are in the area of computational modeling in the understanding and improved design of devices used in neuromodulation treatments.

Affiliations and Expertise

Associate Professor of Neurosurgery, Harvard Medical School, Boston, MA, USA

Jay Shils

Jay Shils

Jay L. Shils, Ph.D., D.ABNM, FASNM, FACNS is currently the director of intraoperative neurophysiological monitoring at Rush University Medical School and an Associate Professor in the department of Anesthesiology at Rush Medical Center. He received his Bachelor of Science degree in electrical engineering from Syracuse University, and both his masters and PhD in Bio-Engineering at The University of Pennsylvania using with his thesis dissertation subject – “The Bispectrum of the Human Electroencephalogram” to investigate interactions in the visual system and study EEG in epilepsy. Dr. Shils has been involved in intraoperative neuromonitoring since 1994 specializing in microelectrode neurophysiology for movement disorders. Dr. Shils is the co-editor of two neuromodulation related books which is one of his primary interests and the first edition of this book. Dr, Shils is a past president of the ASNM and the ISIN and is the founding secretary of the ISIN. Dr. Shils is the present secretary of the ASNM. Over the years Dr. Shils has presented at over 100 national and international has published on MER, DBS, neuromodulation, and intraoperative monitoring techniques.

Affiliations and Expertise

Director of Intraoperative Neurophysiological Monitoring and Associate Professor in Anesthesiology, Rush University Medical Center, Chicago, IL, USA

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