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Essays in Toxicology - 1st Edition - ISBN: 9780121076054, 9781483216454

Essays in Toxicology

1st Edition

Volume 5

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Editor: Wayland J. Hayes
eBook ISBN: 9781483216454
Imprint: Academic Press
Published Date: 1st January 1974
Page Count: 204
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Essays in Toxicology, Volume 5 covers essays in toxicology. The book presents essays on nitrosamines; a laboratory model ecosystem to evaluate compounds producing biological magnification; and the metabolism of DDT in human. The text also includes essays on the toxins of Clostridium botulinum; the use of breath analysis in clinical toxicology; and the biochemical toxicology of methanol. Toxicologists, biochemists, microbiologists, pharmacologists, and people involved in the research of toxicology will find the book invaluable.

Table of Contents

List of Contributors


Contents of Previous Volumes

1. Nitrosamines

I. Introduction

II. Discovery of the Carcinogenic Effects of Nitrosamines

III. What May Be Learned from Study of Nitrosamines


2. A Laboratory Model Ecosystem to Evaluate Compounds Producing Biological Magnification

I. Introduction

II. Development of a Laboratory System for Evaluation of Micropollutants

III. Problems Investigated


3. The Metabolism of DDT in Man

I. Background and Rationale of the Present Study of DDT Metabolism in Man

II. Subjects, Materials, and Methods

III. Absorption and Storage of Ingested DDT

IV. Chemical Conversions of Ingested DDT and DDT Metabolites

V. Relation of Blood Concentrations of DDT Isomers and Metabolites to the Adipose Stores of These Chemicals

VI. Loss of Fat-Stored DDT and DDT Metabolites

VII. Summary and Commentary


4. The Toxins of Clostridium botulinum

I. Introduction

II. Nature and Distribution of Clostridium botulinum

III. Toxin Production

IV. Qualitative and Quantitative Assays for Botulinum Toxins

V. Purification and Properties of the Toxins

VI. Studies on the Relation of Functional Groups to Toxicity

VII. Mechanism of Action of the Toxins

VIII. Diagnosis, Treatment, and Prevention of Botulism


5. The Use of Breath Analysis in Clinical Toxicology

I. Introduction

II. Technique of Breath Analysis

III. Diagnosis of Exposure

IV. Estimation of the Magnitude of Exposure

V. Illustrative Breath Decay Curves

VI. Illustrative Case Reports

VII. Comment


6. The Biochemical Toxicology of Methanol

I. Introduction

II. The Metabolic Disposition of Methanol

III. The Metabolic Disposition of Formaldehyde

IV. The Metabolic Disposition of Formic Acid

V. Summary


Author Index

Subject Index


No. of pages:
© Academic Press 1974
1st January 1974
Academic Press
eBook ISBN:

About the Editor

Wayland J. Hayes

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