Essays in Toxicology

Essays in Toxicology

Volume 5

1st Edition - January 1, 1974

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  • Editor: Wayland J. Hayes
  • eBook ISBN: 9781483216454

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Essays in Toxicology, Volume 5 covers essays in toxicology. The book presents essays on nitrosamines; a laboratory model ecosystem to evaluate compounds producing biological magnification; and the metabolism of DDT in human. The text also includes essays on the toxins of Clostridium botulinum; the use of breath analysis in clinical toxicology; and the biochemical toxicology of methanol. Toxicologists, biochemists, microbiologists, pharmacologists, and people involved in the research of toxicology will find the book invaluable.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1. Nitrosamines

    I. Introduction

    II. Discovery of the Carcinogenic Effects of Nitrosamines

    III. What May Be Learned from Study of Nitrosamines


    2. A Laboratory Model Ecosystem to Evaluate Compounds Producing Biological Magnification

    I. Introduction

    II. Development of a Laboratory System for Evaluation of Micropollutants

    III. Problems Investigated


    3. The Metabolism of DDT in Man

    I. Background and Rationale of the Present Study of DDT Metabolism in Man

    II. Subjects, Materials, and Methods

    III. Absorption and Storage of Ingested DDT

    IV. Chemical Conversions of Ingested DDT and DDT Metabolites

    V. Relation of Blood Concentrations of DDT Isomers and Metabolites to the Adipose Stores of These Chemicals

    VI. Loss of Fat-Stored DDT and DDT Metabolites

    VII. Summary and Commentary


    4. The Toxins of Clostridium botulinum

    I. Introduction

    II. Nature and Distribution of Clostridium botulinum

    III. Toxin Production

    IV. Qualitative and Quantitative Assays for Botulinum Toxins

    V. Purification and Properties of the Toxins

    VI. Studies on the Relation of Functional Groups to Toxicity

    VII. Mechanism of Action of the Toxins

    VIII. Diagnosis, Treatment, and Prevention of Botulism


    5. The Use of Breath Analysis in Clinical Toxicology

    I. Introduction

    II. Technique of Breath Analysis

    III. Diagnosis of Exposure

    IV. Estimation of the Magnitude of Exposure

    V. Illustrative Breath Decay Curves

    VI. Illustrative Case Reports

    VII. Comment


    6. The Biochemical Toxicology of Methanol

    I. Introduction

    II. The Metabolic Disposition of Methanol

    III. The Metabolic Disposition of Formaldehyde

    IV. The Metabolic Disposition of Formic Acid

    V. Summary


    Author Index

    Subject Index

Product details

  • No. of pages: 204
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483216454

About the Editor

Wayland J. Hayes

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