Essays in Toxicology

Essays in Toxicology

Volume 4

1st Edition - January 1, 1973

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  • Editor: Wayland J. Hayes
  • eBook ISBN: 9781483216447

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Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1. Drug Dependence: Whither the Drug

    I. Introduction

    II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism

    III. Distribution of Barbiturates to the Central Nervous System

    IV. Urinary Excretion of Barbiturates

    V. Unmasking the Culprit—Heroin

    VI. Metabolism of Morphine

    VII. Metabolic Transformation of Codeine to Morphine

    VIII. Metabolism of Naloxone

    IX. Excretion of Narcotics and Metabolites in Urine

    X. Transport in Brain

    XI. Placental Transfer

    XII. Biliary Excretion

    XIII. Certain Aspects of Metabolism of Δ°-Tetrahydrocannabinol


    2. Kinetics of Active-Site-Directed Irreversible Inhibition

    I. Introduction

    II. Trivial Names and Symbols

    III. Origins

    IV. Kinetics


    3. Recondite Toxicity of Trace Elements

    I. Introduction

    II. Specific Considerations

    III. General Conclusions

    IV. Recondite Toxicity in Terms of Growth

    V. Effects on Body Weights of Aged Animals

    VI. Effects of Trace Elements on Survival and Longevity

    VII. Effects on Tumors

    VIII. Longevity and Median Life-Span

    IX. Other Manifestations of Recondite Toxicity

    X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice

    XI. Some Clues to Mechanisms of Toxicity

    XII. Production of Chronic Diseases Stimulating Human Disorders

    XIII. Recondite Toxicity of Other Metals or Elements in Man

    XIV. Innate Toxicity from Water

    XV. Summary and Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 230
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483216447

About the Editor

Wayland J. Hayes

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