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Essays in Toxicology
Volume 4
- 1st Edition - January 1, 1973
- Editor: Wayland J. Hayes
- Language: English
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 6 4 4 - 7
Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace… Read more
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Request a sales quoteEssays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.
List of Contributors
Preface
Contents of Previous Volumes
1. Drug Dependence: Whither the Drug
I. Introduction
II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism
III. Distribution of Barbiturates to the Central Nervous System
IV. Urinary Excretion of Barbiturates
V. Unmasking the Culprit—Heroin
VI. Metabolism of Morphine
VII. Metabolic Transformation of Codeine to Morphine
VIII. Metabolism of Naloxone
IX. Excretion of Narcotics and Metabolites in Urine
X. Transport in Brain
XI. Placental Transfer
XII. Biliary Excretion
XIII. Certain Aspects of Metabolism of Δ°-Tetrahydrocannabinol
References
2. Kinetics of Active-Site-Directed Irreversible Inhibition
I. Introduction
II. Trivial Names and Symbols
III. Origins
IV. Kinetics
References
3. Recondite Toxicity of Trace Elements
I. Introduction
II. Specific Considerations
III. General Conclusions
IV. Recondite Toxicity in Terms of Growth
V. Effects on Body Weights of Aged Animals
VI. Effects of Trace Elements on Survival and Longevity
VII. Effects on Tumors
VIII. Longevity and Median Life-Span
IX. Other Manifestations of Recondite Toxicity
X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice
XI. Some Clues to Mechanisms of Toxicity
XII. Production of Chronic Diseases Stimulating Human Disorders
XIII. Recondite Toxicity of Other Metals or Elements in Man
XIV. Innate Toxicity from Water
XV. Summary and Conclusions
References
Author Index
Subject Index
- No. of pages: 230
- Language: English
- Edition: 1
- Published: January 1, 1973
- Imprint: Academic Press
- eBook ISBN: 9781483216447
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