Essays in Toxicology - 1st Edition - ISBN: 9780121076047, 9781483216447

Essays in Toxicology

1st Edition

Volume 4

Editors: Wayland J. Hayes
eBook ISBN: 9781483216447
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 230
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Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

Table of Contents

List of Contributors


Contents of Previous Volumes

1. Drug Dependence: Whither the Drug

I. Introduction

II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism

III. Distribution of Barbiturates to the Central Nervous System

IV. Urinary Excretion of Barbiturates

V. Unmasking the Culprit—Heroin

VI. Metabolism of Morphine

VII. Metabolic Transformation of Codeine to Morphine

VIII. Metabolism of Naloxone

IX. Excretion of Narcotics and Metabolites in Urine

X. Transport in Brain

XI. Placental Transfer

XII. Biliary Excretion

XIII. Certain Aspects of Metabolism of Δ°-Tetrahydrocannabinol


2. Kinetics of Active-Site-Directed Irreversible Inhibition

I. Introduction

II. Trivial Names and Symbols

III. Origins

IV. Kinetics


3. Recondite Toxicity of Trace Elements

I. Introduction

II. Specific Considerations

III. General Conclusions

IV. Recondite Toxicity in Terms of Growth

V. Effects on Body Weights of Aged Animals

VI. Effects of Trace Elements on Survival and Longevity

VII. Effects on Tumors

VIII. Longevity and Median Life-Span

IX. Other Manifestations of Recondite Toxicity

X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice

XI. Some Clues to Mechanisms of Toxicity

XII. Production of Chronic Diseases Stimulating Human Disorders

XIII. Recondite Toxicity of Other Metals or Elements in Man

XIV. Innate Toxicity from Water

XV. Summary and Conclusions


Author Index

Subject Index


No. of pages:
© Academic Press 1973
Academic Press
eBook ISBN:

About the Editor

Wayland J. Hayes

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