Essays in Toxicology

Essays in Toxicology

First published on January 1, 1972

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  • Editor: Wayland J. Hayes
  • eBook ISBN: 9781483262833

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Essays in Toxicology, Volume 3 covers the significant advances in several areas of toxicology, including inhalation toxicology and the tests for toxicity measurement. This volume contains four chapters, and begins with discussion of the mechanisms of pulmonary toxicology, such as the deposition of respirable materials and the cellular role in pulmonary clearance. The subsequent chapter examines the impact of physical environmental factors on drug response, including the effect of ionizing radiation and atmospheric pressure and temperature. These topics are followed by surveys of several toxicological measures for determination of the effects of long-term toxicant exposure. The concluding chapter explores the molecular and biochemical studies of toxicants, specifically their interactions resulting in binding to proteins or nucleic acids. This book will be of value to toxicologists, researchers, teachers, and students who wants to obtain a clearer view of the various aspects of toxicology.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    Frank Raymond Blood 13 September 1910 — 31 January 1971

    1. The Vital Sacs: Alveolar Clearance Mechanisms in Inhalation Toxicology

    I. Introduction

    II. Historical Perspectives

    III. The Exposure Atmosphere

    IV. Gases and Vapors

    V. Deposition of Particulate Material

    VI. Pathways and Rates of Clearance of Particles

    VII. The Cellular Role in Pulmonary Clearance

    VIII. Concluding Comments


    2. The Effect of Physical Environmental Factors on Drug Response

    I. Introduction

    II. Radiation

    III. Pressure

    IV. Temperature


    3. Tests for Detecting and Measuring Long-Term Toxicity

    I. Introduction

    II. The 90-Dose ED50 or LD50

    III. The Chronicity Factor

    IV. The Concentration Index

    V. Discussion


    4. Molecular Aspects of Toxicants

    I. Introduction

    II. Interactions with Specific Enzymes

    III. Microsomal Enzyme Induction

    IV. Interaction with Macromolecules

    V. Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 122
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9781483262833

About the Editor

Wayland J. Hayes

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