Essays in Toxicology

Essays in Toxicology

Volume 1

1st Edition - January 1, 1969

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  • Editor: Frank R. Blood
  • eBook ISBN: 9781483213965

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Essays in Toxicology, Volume 1 covers essays in toxicology and related topics. The book presents essays on the use of poisons as tools in studying the nervous system as well as teratology. The text also includes essays on the significance of methemoglobinemia in toxicology and lead poisoning. Biochemists, plant and animal physiologists, pharmacologists, pathologists, microbiologists, entomologists, food technologist, and people involved in forensic medicine and industrial medicine.

Table of Contents

  • List Of Contributors


    1. Poisons as Tools in Studying the Nervous System

    I. Introduction

    II. Axonic Transmission

    A. The Poisons

    B. The System

    III. Excitatory Synaptic Transmission

    A. The Poisons

    B. Actions on the Receptor

    C. Actions on Transmitter Synthesis and Release

    D. Actions on Transmitter Destruction

    IV. Inhibitory Synaptic Transmission

    A. The Poisons

    B. Inhibition in Vertebrates

    C. Inhibition in Invertebrates

    D. Inhibition: Current and Future Uses of Poisons


    2. Teratology

    I. Introduction

    II. Placental Physiology

    III. Research Needs

    IV. Nutritional Aspects

    V. Genetic Factors

    VI. Drugs

    VII. Infectious Diseases

    VIII. Mechanistic Causes

    IX. Conclusion


    3. The Significance of Methemoglobinemia in Toxicology

    I. Introduction

    II. Therapeutic and Experimental Applications

    A. Cyanide Poisoning

    B. Sulfide Poisoning

    C. Miscellaneous Toxic Anions

    III. Methemoglobinemia as a Toxic Reaction

    A. Hypoxic Responses of Man and Animals

    B. Cause of Death in Methemoglobinemia

    C. Treatment of Toxic Methemoglobinemia

    IV. Pharmacology of Methylene Blue

    A. Methemoglobin Formation by Methylene Blue

    B. Cyanide Poisoning

    C. Carbon Monoxide Poisoning

    D. Methylene Blue in Oxygen Lack

    E. Miscellaneous Actions

    V. Summary


    4. Lead Poisoning. An Old Problem with a New Dimension

    I. Introduction

    II. Historical Background

    III. Industrial Lead Poisoning

    IV. Lead Poisoning in Infants

    V. Lead Poisoning in Domesticated Animals and Wildlife

    VI. Sources and Uses of Lead

    VII. Tetraethyl Lead and the General Environment

    VIII. Perspectives Regarding Problem-Solving

    IX. Current Knowledge Bearing on Existing Problems

    X. The Metabolism of Lead

    A. Absorption

    B. The Fate of Lead in the Body

    XI. Toxic Effects of Lead

    A. The Effect of Lead on the Hemopoietic System

    B. Effects of Lead on the Central and Peripheral Nervous System

    C. Effects of Lead on the Kidney

    D. Miscellaneous Effects

    XII. Lead as Related to the Incidence of Diseases

    XIII. The Body Burden of Lead in the General Population

    A. Estimates of Body Burden

    B. Environment and the Body Burden

    XIV. The Evaluation of Blood Levels

    A. "Classic" Lead Poisoning

    B. Lead-Related Diseases

    XV. The Role of Animal Experimentation

    XVI. The New Dimension


    Author Index

    Subject Index

Product details

  • No. of pages: 182
  • Language: English
  • Copyright: © Academic Press 1969
  • Published: January 1, 1969
  • Imprint: Academic Press
  • eBook ISBN: 9781483213965

About the Editor

Frank R. Blood

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