Essays in Toxicology - 1st Edition - ISBN: 9780121076511, 9781483213965

Essays in Toxicology

1st Edition

Volume 1

Editors: Frank R. Blood
eBook ISBN: 9781483213965
Imprint: Academic Press
Published Date: 1st January 1969
Page Count: 182
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Essays in Toxicology, Volume 1 covers essays in toxicology and related topics. The book presents essays on the use of poisons as tools in studying the nervous system as well as teratology. The text also includes essays on the significance of methemoglobinemia in toxicology and lead poisoning. Biochemists, plant and animal physiologists, pharmacologists, pathologists, microbiologists, entomologists, food technologist, and people involved in forensic medicine and industrial medicine.

Table of Contents

List Of Contributors


1. Poisons as Tools in Studying the Nervous System

I. Introduction

II. Axonic Transmission

A. The Poisons

B. The System

III. Excitatory Synaptic Transmission

A. The Poisons

B. Actions on the Receptor

C. Actions on Transmitter Synthesis and Release

D. Actions on Transmitter Destruction

IV. Inhibitory Synaptic Transmission

A. The Poisons

B. Inhibition in Vertebrates

C. Inhibition in Invertebrates

D. Inhibition: Current and Future Uses of Poisons


2. Teratology

I. Introduction

II. Placental Physiology

III. Research Needs

IV. Nutritional Aspects

V. Genetic Factors

VI. Drugs

VII. Infectious Diseases

VIII. Mechanistic Causes

IX. Conclusion


3. The Significance of Methemoglobinemia in Toxicology

I. Introduction

II. Therapeutic and Experimental Applications

A. Cyanide Poisoning

B. Sulfide Poisoning

C. Miscellaneous Toxic Anions

III. Methemoglobinemia as a Toxic Reaction

A. Hypoxic Responses of Man and Animals

B. Cause of Death in Methemoglobinemia

C. Treatment of Toxic Methemoglobinemia

IV. Pharmacology of Methylene Blue

A. Methemoglobin Formation by Methylene Blue

B. Cyanide Poisoning

C. Carbon Monoxide Poisoning

D. Methylene Blue in Oxygen Lack

E. Miscellaneous Actions

V. Summary


4. Lead Poisoning. An Old Problem with a New Dimension

I. Introduction

II. Historical Background

III. Industrial Lead Poisoning

IV. Lead Poisoning in Infants

V. Lead Poisoning in Domesticated Animals and Wildlife

VI. Sources and Uses of Lead

VII. Tetraethyl Lead and the General Environment

VIII. Perspectives Regarding Problem-Solving

IX. Current Knowledge Bearing on Existing Problems

X. The Metabolism of Lead

A. Absorption

B. The Fate of Lead in the Body

XI. Toxic Effects of Lead

A. The Effect of Lead on the Hemopoietic System

B. Effects of Lead on the Central and Peripheral Nervous System

C. Effects of Lead on the Kidney

D. Miscellaneous Effects

XII. Lead as Related to the Incidence of Diseases

XIII. The Body Burden of Lead in the General Population

A. Estimates of Body Burden

B. Environment and the Body Burden

XIV. The Evaluation of Blood Levels

A. "Classic" Lead Poisoning

B. Lead-Related Diseases

XV. The Role of Animal Experimentation

XVI. The New Dimension


Author Index

Subject Index


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© Academic Press 1969
Academic Press
eBook ISBN:

About the Editor

Frank R. Blood

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