Escherichia coli

2nd Edition

Pathotypes and Principles of Pathogenesis

Editors: Michael Donnenberg
Hardcover ISBN: 9780123970480
eBook ISBN: 9780123977779
Imprint: Academic Press
Published Date: 5th August 2013
Page Count: 612
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The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures.

Key Features

  • Offers a single source of information of E. coli pathogenesis written by expert authors
  • Presents comprehensive coverage on molecular mechanisms, biology, evolution and genomics and recent advances


Microbiologists, cell biologists, infectious disease clinicians, food safety experts, veterinarians, and advanced students.

Table of Contents

List of Contributors



Section I: Escherichia coli, the organism

Chapter 1. The ecology of Escherichia coli

The genus Escherichia

Where does E. coli occur?

Genetic structure of E. coli

Within and among host E. coli diversity

Host specificity

Population dynamics of intestinal pathogens


Chapter 2. Comparative genomics of pathogenic Escherichia coli


Uropathogenic E. coli

Shiga-toxin producing E. coli/enterohemorrhagic E. coli (STEC/EHEC)

Enteropathogenic E. coli (EPEC)

Enterotoxigenic E. coli (ETEC)

Enteroaggregative E. coli (EAEC)

Diffusely adherent E. coli (DAEC) and adherent invasive E. coli (AIEC)

Shigella and enteroinvasive E. coli (EIEC)

Future directions



Chapter 3. Evolution of pathogenic Escherichia coli


Within-species diversity of pathogenic E. coli

Genetic mechanisms of virulence evolution

Evolutionarily adapted and pre-adapted virulence factors

Why did E. coli evolve to be pathogenic?

Evolutionary models, source-sinks, and paradoxes

Population genomics and variome of microbial pathogens


Section II: Escherichia coli pathotypes

Chapter 4. Enteropathogenic Escherichia coli


Molecular pathogenesis

Clinical manifestations


Chapter 5. Enterohemorrhagic and other Shigatoxin-producing Escherichia coli


Molecular pathogenesis

Clinical manifestations






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About the Editor

Michael Donnenberg

Michael Donnenberg, MD is a Professor of Medicine and of Microbiology and Immunology at the University of Maryland. Dr. Donnenberg is a graduate of the Columbia University College of Physicians and Surgeons. He completed residency in Internal Medicine at what is now the Bayview Campus of Johns Hopkins and fellowship in Infectious Diseases at Tufts/New England Medical Center. After additional postdoctoral research training at the Center for Vaccine Development at the University of Maryland, Dr. Donnenberg joined the faculty in 1990. Dr. Donnenberg’s research has focused on the molecular pathogenesis of infections due to Escherichia coli and on the biogenesis and function of bacterial surface appendages called Type IV Pili that are used by many pathogens to adhere to host cell surfaces. His work has been continuously funded by the National Institutes of Health for over twenty years and has resulted in the publication of over one hundred original manuscripts, reviews, and book chapters. He is a Fellow of the Infectious Diseases Society of America and the American Academy of Microbiology and a member of the American Society for Clinical Investigation. He is a recipient of the Oswald Avery Award from the Infectious Diseases Society of America. Dr. Donnenberg is an active Infectious Diseases clinician and directs the Medical Scientist (MD/PhD) Program at the University of Maryland. He is also active in medical education and was an inaugural member of the Pass and Susel Academy of Academic Excellence at the University of Maryland.

Affiliations and Expertise

University of Maryland School of Medicine, Baltimore, U.S.A.


"The Escherichia coli (E. coli) bacteria is the most common facultative anaerobe in the human intestinal tract, and most strains are non-pathogenic and even symbiotic. It is the pathogenic strains that scientists from around the world consider here, looking at the organism itself, pathotypes, and virulence factors."--Reference & Research Book News, October 2013