Description

The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures.

Key Features

  • Offers a single source of information of E. coli pathogenesis written by expert authors
  • Presents comprehensive coverage on molecular mechanisms, biology, evolution and genomics and recent advances

Readership

Microbiologists, cell biologists, infectious disease clinicians, food safety experts, veterinarians, and advanced students.

Table of Contents

List of Contributors

Introduction

References

Section I: Escherichia coli, the organism

Chapter 1. The ecology of Escherichia coli

The genus Escherichia

Where does E. coli occur?

Genetic structure of E. coli

Within and among host E. coli diversity

Host specificity

Population dynamics of intestinal pathogens

References

Chapter 2. Comparative genomics of pathogenic Escherichia coli

Introduction

Uropathogenic E. coli

Shiga-toxin producing E. coli/enterohemorrhagic E. coli (STEC/EHEC)

Enteropathogenic E. coli (EPEC)

Enterotoxigenic E. coli (ETEC)

Enteroaggregative E. coli (EAEC)

Diffusely adherent E. coli (DAEC) and adherent invasive E. coli (AIEC)

Shigella and enteroinvasive E. coli (EIEC)

Future directions

Acknowledgments

References

Chapter 3. Evolution of pathogenic Escherichia coli

Introduction

Within-species diversity of pathogenic E. coli

Genetic mechanisms of virulence evolution

Evolutionarily adapted and pre-adapted virulence factors

Why did E. coli evolve to be pathogenic?

Evolutionary models, source-sinks, and paradoxes

Population genomics and variome of microbial pathogens

References

Section II: Escherichia coli pathotypes

Chapter 4. Enteropathogenic Escherichia coli

Background

Molecular pathogenesis

Clinical manifestations

References

Chapter 5. Enterohemorrhagic and other Shigatoxin-producing Escherichia coli

Background

Molecular pathogenesis

Clinical manifestations

Conclusion

Acknowledgments

References

Chap

Details

No. of pages:
612
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780123977779
Print ISBN:
9780123970480

Reviews

The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures.