Escherichia coli

Escherichia coli

Pathotypes and Principles of Pathogenesis

2nd Edition - June 12, 2013

Write a review

  • Editor: Michael Donnenberg
  • Hardcover ISBN: 9780123970480
  • eBook ISBN: 9780123977779

Purchase options

Purchase options
Available
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures.

Key Features

  • Offers a single source of information of E. coli pathogenesis written by expert authors
  • Presents comprehensive coverage on molecular mechanisms, biology, evolution and genomics and recent advances

Readership

Microbiologists, cell biologists, infectious disease clinicians, food safety experts, veterinarians, and advanced students.

Table of Contents

  • List of Contributors

    Introduction

    References

    Section I: Escherichia coli, the organism

    Chapter 1. The ecology of Escherichia coli

    The genus Escherichia

    Where does E. coli occur?

    Genetic structure of E. coli

    Within and among host E. coli diversity

    Host specificity

    Population dynamics of intestinal pathogens

    References

    Chapter 2. Comparative genomics of pathogenic Escherichia coli

    Introduction

    Uropathogenic E. coli

    Shiga-toxin producing E. coli/enterohemorrhagic E. coli (STEC/EHEC)

    Enteropathogenic E. coli (EPEC)

    Enterotoxigenic E. coli (ETEC)

    Enteroaggregative E. coli (EAEC)

    Diffusely adherent E. coli (DAEC) and adherent invasive E. coli (AIEC)

    Shigella and enteroinvasive E. coli (EIEC)

    Future directions

    Acknowledgments

    References

    Chapter 3. Evolution of pathogenic Escherichia coli

    Introduction

    Within-species diversity of pathogenic E. coli

    Genetic mechanisms of virulence evolution

    Evolutionarily adapted and pre-adapted virulence factors

    Why did E. coli evolve to be pathogenic?

    Evolutionary models, source-sinks, and paradoxes

    Population genomics and variome of microbial pathogens

    References

    Section II: Escherichia coli pathotypes

    Chapter 4. Enteropathogenic Escherichia coli

    Background

    Molecular pathogenesis

    Clinical manifestations

    References

    Chapter 5. Enterohemorrhagic and other Shigatoxin-producing Escherichia coli

    Background

    Molecular pathogenesis

    Clinical manifestations

    Conclusion

    Acknowledgments

    References

    Chapter 6. Enterotoxigenic Escherichia coli

    Background

    Molecular pathogenesis

    Clinical manifestations

    Control and prevention

    Conclusions

    References

    Chapter 7. Shigella and enteroinvasive Escherichia coli: Paradigms for pathogen evolution and host–parasite interactions

    Background

    Molecular pathogenesis

    Clinical manifestations of disease

    Conclusion

    Acknowledgments

    References

    Chapter 8. Enteroaggregative Escherichia coli

    Introduction

    Enteroaggregative Escherichia coli (EAEC) history

    Epidemiology

    Clinical manifestations of infection

    Microbial pathogenesis

    Inflammation in EAEC pathogenesis

    Strain heterogeneity

    Identification of EAEC

    References

    Chapter 9. Uropathogenic Escherichia coli

    Background

    Molecular pathogenesis

    Clinical manifestations

    Conclusions

    References

    Chapter 10. Meningitis-associated Escherichia coli

    Introduction

    E. coli traversal of the blood–brain barrier

    Identification of microbial factors involved in E. coli meningitis by functional genomic approaches

    Prevention of E. coli penetration into the brain by targeting the microbial–host factors contributing to E. coli invasion of HBMEC monolayer

    The basis for neurotropism in E. coli meningitis

    The mechanisms involved in CNS inflammation in response to bacterial meningitis

    Neuronal injury following E. coli meningitis

    Conclusions

    Acknowledgments

    References

    Chapter 11. Hybrid and potentially pathogenic Escherichia coli strains

    Diffusely adherent E. coli (DAEC)

    Adherent and invasive E. coli (AIEC)

    Shiga toxin-producing E. coli O104:H4

    Conclusions

    References

    Section III: Escherichia coli virulence factors

    Chapter 12. Adhesive pili of the chaperone-usher family

    Introduction

    Pilus architecture

    Chaperones

    Subunits

    Ushers

    Role of CU pili in infections

    CU pili as antivirulence targets

    Conclusion

    References

    Chapter 13. The type 2 secretion and type 4 pilus systems of Escherichia coli

    Introduction

    Genetic organization

    Regulation

    Structural components of T2S and T4P machines

    Mechanism of action

    Role in virulence

    Immune responses

    Therapeutics and vaccine prospects

    Antivirulence drugs

    Conclusions

    References

    Chapter 14. Type 3 secretion systems

    Introduction

    Type 3 secretion systems in E. coli

    Structure and organization of the T3SS injectisome

    Mechanism of secretion and assembly

    Regulation of Type 3 secretion

    Conclusion

    References

    Chapter 15. Type 3 secretion effectors

    Introduction

    Cytoskeleton remodeling

    Manipulation of host immune responses

    Cell death and survival

    Disrupting gut integrity: diarrheagenic mechanism

    Conclusion

    References

    Chapter 16. Type 1 and 5 secretion systems and associated toxins

    Introduction

    The type 1 secretion system

    The Type 5 secretion system

    Molecular organization

    Secretion

    Structure of T5SS domains

    Processing of T5SS passenger domains

    Distribution, function, and regulation

    Type 1 and 5 secreted proteins as prospects for vaccines

    Conclusions

    References

    Chapter 17. Capsule and lipopolysaccharide

    Introduction

    Structure and biosynthesis of E. coli LPS

    Structure and biosynthesis of E. coli CPSs

    Evasion of host cell defenses

    Other roles in virulence

    Conclusions

    References

    Index

Product details

  • No. of pages: 612
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: June 12, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123970480
  • eBook ISBN: 9780123977779

About the Editor

Michael Donnenberg

Michael Donnenberg
Michael Donnenberg, MD is a Professor of Medicine and of Microbiology and Immunology at the University of Maryland. Dr. Donnenberg is a graduate of the Columbia University College of Physicians and Surgeons. He completed residency in Internal Medicine at what is now the Bayview Campus of Johns Hopkins and fellowship in Infectious Diseases at Tufts/New England Medical Center. After additional postdoctoral research training at the Center for Vaccine Development at the University of Maryland, Dr. Donnenberg joined the faculty in 1990.

Dr. Donnenberg’s research has focused on the molecular pathogenesis of infections due to Escherichia coli and on the biogenesis and function of bacterial surface appendages called Type IV Pili that are used by many pathogens to adhere to host cell surfaces. His work has been continuously funded by the National Institutes of Health for over twenty years and has resulted in the publication of over one hundred original manuscripts, reviews, and book chapters. He is a Fellow of the Infectious Diseases Society of America and the American Academy of Microbiology and a member of the American Society for Clinical Investigation. He is a recipient of the Oswald Avery Award from the Infectious Diseases Society of America.

Dr. Donnenberg is an active Infectious Diseases clinician and directs the Medical Scientist (MD/PhD) Program at the University of Maryland. He is also active in medical education and was an inaugural member of the Pass and Susel Academy of Academic Excellence at the University of Maryland.

Affiliations and Expertise

University of Maryland School of Medicine, Baltimore, U.S.A.

Ratings and Reviews

Write a review

There are currently no reviews for "Escherichia coli"