1st Edition - June 24, 2017

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780128122655
  • eBook ISBN: 9780128122662

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Erythropoietin, Volume 105, the latest release in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. Topics covered in this new volume include Erythropoietin Receptor Structural Domains, Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists, Endogenous Erythropoietin, Erythropoietin Receptor Signaling and Lipid Rafts, and Erythropoietin and Hypothalamic-Pituitary Axis. Each thoroughly reviewed volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors and others. This volume documents the activities of this vital molecule, also describing the structure and function of erythropoietin and its receptor.

Key Features

  • Presents the latest information on erythropoietin
  • Provides a long-running series that focuses on updates and advances in vitamins and hormones
  • Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances


Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Table of Contents

  • 1. Erythropoietin Receptor Structural Domains
    Qingxin Li and CongBao Kang
    2. Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists
    Frank Guarnieri
    3. Endogenous Erythropoietin
    Steven J. Korzeniewski and Athina Pappas
    4. Erythropoietin Regulation by Angiotensin II
    Yong-Chul Kim, Ognoon Mungunsukh and Regina M. Day
    5. Erythropoietin Receptor Signaling and Lipid Rafts
    Kathy McGraw and Alan List
    6. Erythropoietin and Hypothalamic-Pituitary Axis
    Soumyadeep Dey and Constance T. Noguchi
    7 Erythropoietin-Mediated Regulation of Central Respiratory Command
    Tommy Seaborn and Céline Caravagna
    8. Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis
    Ilona Rybinska and Gaetano Cairo
    9. Context-Dependent Skeletal Effects of Erythropoietin
    Sahar Hiram-Bab, Drorit Neumann and Yankel Gabet
    10. Erythropoietin-Mediated Neuroprotection in Insects Suggests a Prevertebrate Evolution of Erythropoietin-Like Signaling
    Ralf Heinrich, Verena Günther and Natasa Miljus
    11. Erythropoietin: Endogenous Protection of Ischemic Brain
    Robert T. Mallet and Myoung-Gwi Ryou
    12. The Erythropoietin System Protects the Heart Upon Injury by Cardiac Progenitor Cell Activation
    Maria P. Zafeiriou
    13. Erythropoietin Promotes Glioblastoma via miR-451 Suppression
    Begum Alural, Zeynep O. Ayyildiz, Kemal U. Tufekci, Sermin Genc and Kursad Genc
    14. Erythropoietin, Stem Cell Factor, and Cancer Cell Migration
    Maria J. Vazquez-Mellado, Victor M. Embriz and Leticia Rocha-Zavaleta
    15. Significance of Erythropoietin Receptor Antagonist EMP9 in Cancers
    Yoshiko Yasuda and Mitsugu Fujita

Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: June 24, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128122655
  • eBook ISBN: 9780128122662

About the Serial Editor

Gerald Litwack

Dr. Litwack was formerly Professor of Molecular and Cellular Medicine and Associate Director at the Institute for Regenerative Medicine, Texas A & M Health Science Center.

Affiliations and Expertise

Toluca Lake, North Hollywood, CA, USA

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