- Print ISBN 9780444528988
- Electronic ISBN 9780444535054
Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.
Handbook of Clinical Neurology 3rd Series
Chapter 1 Molecular basis of acquired epileptogenesis
Which genes are altered at different phases of epileptic process and what is their function?
Chapter 2 Cellular bases of focal and generalized epilepsies
Intrinsic properties of neurons
Synaptic properties of neurons
Modulation of neuronal excitability
Chapter 3 Epilepsy as a dynamic disease of neuronal networks
How may the stability of neuronal networks be maintained and disturbed in epilepsy?
How may transitions between normal and epileptic behavior occur in thalamocortical networks?
How may transitions between normal and epileptic behavior occur in neuronal networks of the hippocampal system?
How may neuronal networks involved in epileptic behavior be identified and analyzed in a clinical setting?
Conclusion: general concepts and models
Chapter 4 Animal models
In vitro models
In vivo animal models
Determination of seizure susceptibility
Syndromes or encephalopathies (not genetically induced)
Chapter 5 Classification of epilepsies and seizures: historical perspective and future directions
Generalized versus focal: a nondichotomy?
Terms and concepts for grouping etiology
Abandoning the rigid structure of the 1989 classification
Chapter 6 The epidemiology of the epilepsies
Risk factors for epilepsy
Chapter 7 Maturation of the human brain
"Stefan…and Theodore…present the first of two volumes for clinicians and neuroscientists on the clinical features and management of the neurological manifestations of epilepsy…neurologists, neuroscientists, epilepsy specialists, geneticists, and neurosurgeons from North America, Europe, Australia, and Japan address basic mechanisms;… the diagnosis of various types; …and various types of imaging. " --Reference and Research Book News, December 2013