Description

Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

Key Features

  • A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology
  • International list of contributors including the leading workers in the field
  • Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care

Readership

Clinical neurologists and research neuroscientists

Table of Contents

Series Page

Handbook of Clinical Neurology 3rd Series

Foreword

Preface

Contributors

Chapter 1 Molecular basis of acquired epileptogenesis

Introduction

Which genes are altered at different phases of epileptic process and what is their function?

Conclusion

Chapter 2 Cellular bases of focal and generalized epilepsies

Introduction

Intrinsic properties of neurons

Synaptic properties of neurons

Modulation of neuronal excitability

Pathological processes

Concluding comment

Chapter 3 Epilepsy as a dynamic disease of neuronal networks

Introduction

How may the stability of neuronal networks be maintained and disturbed in epilepsy?

How may transitions between normal and epileptic behavior occur in thalamocortical networks?

How may transitions between normal and epileptic behavior occur in neuronal networks of the hippocampal system?

How may neuronal networks involved in epileptic behavior be identified and analyzed in a clinical setting?

Conclusion: general concepts and models

Chapter 4 Animal models

Introduction

In vitro models

In vivo animal models

Determination of seizure susceptibility

Models

Syndromes or encephalopathies (not genetically induced)

Genetic models

Summary

Chapter 5 Classification of epilepsies and seizures: historical perspective and future directions

Introduction

Generalized versus focal: a nondichotomy?

Terms and concepts for grouping etiology

Abandoning the rigid structure of the 1989 classification

Chapter 6 The epidemiology of the epilepsies

Introduction

Definitions

Incidence studies

Prevalence

Risk factors for epilepsy

Prognosis

Mortality

Conclusion

Chapter 7 Maturation of the human brain

Details

No. of pages:
548
Language:
English
Copyright:
© 2012
Published:
Imprint:
Elsevier
Print ISBN:
9780444528988
Electronic ISBN:
9780444535054

Reviews

"Stefan…and Theodore…present the first of two volumes for clinicians and neuroscientists on the clinical features and management of the neurological manifestations of epilepsy…neurologists, neuroscientists, epilepsy specialists, geneticists, and neurosurgeons from North America, Europe, Australia, and Japan address basic mechanisms;… the diagnosis of various types; …and various types of imaging. " --Reference and Research Book News, December 2013