Epigenetics of Aging and Longevity
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Epigenetics of Aging and Longevity

Translational Epigenetics vol 4

1st Edition - November 13, 2017
  • Editors: Alexey Moskalev, Alexander M. Vaiserman
  • Hardcover ISBN: 9780128110607
  • eBook ISBN: 9780128110836

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Description

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

Key Features

  • Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease
  • Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory
  • Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Readership

Researchers, clinicians and graduate students in genomic medicine, epigenetics, and biogerontology interested in the genetics of aging and treating age-related diseases

Table of Contents

  • Section I: Epigenetic Mechanisms in Aging
    1. Aging epigenetics: changes and challenges
    Duygu Ucar and Bérénice A. Benayoun

    2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns
    Michele Zampieri, Fabio Ciccarone, Paola Caiafa

    3. S-adenosylmethionine Metabolism and Aging
    W.A.M. Loenen

    4. The Epigenetic Clock and Ageing
    Ken Raj

    5. The Epigenetic Regulation of Telomere Maintenance in Aging
    Huda Adwan-Shekhidem and Gil Atzmon

    6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype?
    Irene Maeve Rea and Ken I Mills; ACUME2 project

    7. Epigenetic Biomarkers for Biological Age
    Arnold B. Mitnitski

    8. The Role of Non-Coding RNAs in Genome Stability and Aging
    Igor Kovalchuk

    9. Intra-tissue DNA methylation heterogeneity in aging
    Jan Vijg, Silvia Gravina, Xiao Dong

    Section II. Early-life Epigenetic Programming of Aging Trajectories
    10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life
    Clare M Reynolds, Justin M O’Sullivan, Stephanie A Segovia, Mark H Vickers

    11. Early Nutrition, Epigenetics and Human Health
    Simon C. Langley-Evans and Beverly S. Muhlhausler

    12. Biological Embedding of Psychosocial Stress over the Life Course
    Helen Eachus and Vincent T. Cunliffe

    13. Epigenetics of longevity in social insects
    Alexander M. Vaiserman, Oleh V. Lushchak and Alexander K. Koliada

    Section III. Epigenetics of Aging-Associated Diseases
    14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
    Ilya Solovyov, Mikhail Shaposhnikov, Anna Kudryavtseva, Alexey Moskalev

    15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms
    Xiaohua Cao and Weiwei Dang


    16. Epigenetics of brain/cognitive aging
    Xiangru Xu

    17. The role of epigenetic modifications in cardiometabolic diseases
    Kim V.E. Braun, Eliana Portilla, Rajiv Chowdhury, Jana Nano, Jenna Troup, Trudy Voortman, Oscar H. Franco, Taulant Muka

    18. Epigenetic mechanisms in osteoporosis
    Barbara Ostanek, Tilen Kranjc, Nika Lovšin, Janja Zupan, Janja Marc

    19. Epigenetics of Skeletal Muscle Aging
    Adam P. Sharples, Robert A. Seaborne and Claire E. Stewart

    Section IV. Epigenome-targeted Therapies in Gerocscience
    20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective
    Sunitha Meruvu, John D. Bowman, Mahua Choudhury

    21. Epigenetic Drugs for Cancer and Precision Medicine
    Mukesh Verma and Vineet Kumar

    22. Epigenetic Drug Discovery for Alzheimer’s Disease
    Ramón Cacabelos, Oscar Teijido

    Section V. Conclusions and Perspectives
    23. Epigenetics of aging and longevity: challenges and future directions
    Axel Schumacher

Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: November 13, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128110607
  • eBook ISBN: 9780128110836

About the Editors

Alexey Moskalev

Dr. Alexey Moskalev earned his PhD from Moscow State University, Moscow, Russia in 2001. Since that time, Dr. Moskalev’s research has focused on the genetics of longevity and aging, with emphasis on epigenetic regulation of aging, longevity, and stress resistance in animal models. He was a key contributor towards creating a database of biomarkers of aging in the Digital Ageing Atlas (DAA), and his lab has been supported by grants from the Russian Basic Research Foundation, the Presidium of the Russian Academy of Sciences, and the President of the Russian Federation through a program that funds leading young scientists. Currently, Dr. Moskalev is Vice-President of the Syktyvkar Branch of Russian Gerontology Society; President of the Komi branch of the Vavilov Society of Geneticists and Breeders; and a member of the editorial boards of Aging, Biogerontology, Frontiers in Genetics of Aging, Aging and Disease, Genes & Cells, and the SM Journal of Food and Nutritional Disorders. Additionally, he is Co-chair of the International Symposiums “Genetics of Aging and Longevity” and “Biomedical Innovation For Healthy Longevity”. Dr. Moskalev has published more than eighty scientific papers in peer reviewed journals on topics related to the genetics of aging and longevity, as well as DNR repair and defense genes in animal models.

Affiliations and Expertise

Head of the Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology, Komi Science Center of RAS, Syktyvkar, Russia

Alexander M. Vaiserman

Dr. Vaiserman is head of the Laboratory of Epigenetics at the Institute of Gerontology, where his research has focused on long-term health consequences of adverse conditions in early life, genetic and epigenetic mechanisms of age-associated diseases, telomere length in patients with age-related chronic diseases, and molecular mechanisms mediating lifespan in Drosophila. He earned his PhD from the Institute of Gerontology, Kiev, Ukraine in 2004. During the last 7 years, Dr. Vaiserman was Project Leader for several Ukrainian government sponsored research projects. Dr. Vaiserman is also a member of the editorial boards of the journals Biogerontology, Frontiers in Genetics of Aging, and Gerontology & Geriatric Research. To-date, he has published four book chapters, as well as 65 papers in peer reviewed journals.

Affiliations and Expertise

Head of the Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine