
Epigenetics of Aging and Longevity
Translational Epigenetics vol 4
Description
Key Features
- Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease
- Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory
- Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
Readership
Table of Contents
Section I: Epigenetic Mechanisms in Aging
1. Aging epigenetics: changes and challenges
Duygu Ucar and Bérénice A. Benayoun2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns
Michele Zampieri, Fabio Ciccarone, Paola Caiafa3. S-adenosylmethionine Metabolism and Aging
W.A.M. Loenen4. The Epigenetic Clock and Ageing
Ken Raj5. The Epigenetic Regulation of Telomere Maintenance in Aging
Huda Adwan-Shekhidem and Gil Atzmon6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype?
Irene Maeve Rea and Ken I Mills; ACUME2 project7. Epigenetic Biomarkers for Biological Age
Arnold B. Mitnitski8. The Role of Non-Coding RNAs in Genome Stability and Aging
Igor Kovalchuk9. Intra-tissue DNA methylation heterogeneity in aging
Jan Vijg, Silvia Gravina, Xiao DongSection II. Early-life Epigenetic Programming of Aging Trajectories
10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life
Clare M Reynolds, Justin M O’Sullivan, Stephanie A Segovia, Mark H Vickers11. Early Nutrition, Epigenetics and Human Health
Simon C. Langley-Evans and Beverly S. Muhlhausler12. Biological Embedding of Psychosocial Stress over the Life Course
Helen Eachus and Vincent T. Cunliffe13. Epigenetics of longevity in social insects
Alexander M. Vaiserman, Oleh V. Lushchak and Alexander K. KoliadaSection III. Epigenetics of Aging-Associated Diseases
14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
Ilya Solovyov, Mikhail Shaposhnikov, Anna Kudryavtseva, Alexey Moskalev15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms
Xiaohua Cao and Weiwei Dang
16. Epigenetics of brain/cognitive aging
Xiangru Xu17. The role of epigenetic modifications in cardiometabolic diseases
Kim V.E. Braun, Eliana Portilla, Rajiv Chowdhury, Jana Nano, Jenna Troup, Trudy Voortman, Oscar H. Franco, Taulant Muka18. Epigenetic mechanisms in osteoporosis
Barbara Ostanek, Tilen Kranjc, Nika Lovšin, Janja Zupan, Janja Marc19. Epigenetics of Skeletal Muscle Aging
Adam P. Sharples, Robert A. Seaborne and Claire E. StewartSection IV. Epigenome-targeted Therapies in Gerocscience
20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective
Sunitha Meruvu, John D. Bowman, Mahua Choudhury21. Epigenetic Drugs for Cancer and Precision Medicine
Mukesh Verma and Vineet Kumar22. Epigenetic Drug Discovery for Alzheimer’s Disease
Ramón Cacabelos, Oscar TeijidoSection V. Conclusions and Perspectives
23. Epigenetics of aging and longevity: challenges and future directions
Axel Schumacher
Product details
- No. of pages: 544
- Language: English
- Copyright: © Academic Press 2017
- Published: November 13, 2017
- Imprint: Academic Press
- Hardcover ISBN: 9780128110607
- eBook ISBN: 9780128110836
About the Editors
Alexey Moskalev
Affiliations and Expertise
Alexander M. Vaiserman
Affiliations and Expertise
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