Epigenetics in Psychiatry

Epigenetics in Psychiatry

2nd Edition - August 16, 2021

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  • Editors: Jacob Peedicayil, Dennis Grayson, Dimitri Avramopoulos
  • eBook ISBN: 9780128235782
  • Paperback ISBN: 9780128235775

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Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

Key Features

  • Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease
  • Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins
  • Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery
  • Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS)
  • Features chapter contributions from international leaders in the field


Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, neuroscience, neurology and psychiatry; life science researchers; developmental biologists. Clinicians and graduate students in the biosciences; psychiatrists; psychologists; mental health counselors

Table of Contents

  • Part 1: General Aspects of Epigenetics in Psychiatry
    1. Introduction to Epigenetics in Psychiatry
    Dimitrios Avramopoulos and Richard S. Lee
    2. Outline of Epigenetics
    Sebanti Ganguly, Trygve Tollefsbol and Bidisha Paul
    3. A Brief History of Epigenetics in Psychiatry
    Jacob Peedicayil
    4. Roles of Epigenetics in the Neural Stem Cell and Neuron
    Kinichi Nakashima
    5. Role of Epigenetics in the Brain
    Tania Roth, Stephanie Matt and Eric Roth
    6. Epigenetic Epidemiology of Psychiatric Disorders
    Monica Uddin and Jan Dahrendorff
    7. ATAC-seq and Psychiatric Disorders
    Panos Roussos
    8. Single Cell RNA Sequencing and Psychiatric Disorders
    W. Brad Ruzicka
    9. Single Cell Analysis and Psychiatric Disorders
    James H. Eberwine
    10. Laboratory Techniques in Psychiatric Epigenetics
    Chris Murgatroyd
    11. Laboratory Epigenetic Models of Schizophrenia
    Dennis R. Grayson and Jeffrey Dunn
    12. Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
    Jacob Peedicayil

    Part 2: Epigenetics of Psychiatric Disorders
    13. 5-Methycytosine and 5-Hydroxymethylcytosine in Schizophrenia
    Dennis R. Grayson and Jeffrey Dunn
    14. Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
    Hamid M. Abdolmaleky
    15. Non-Coding RNAs and Psychiatric Disorders
    Jacob Peedicayil and Natalie J. Beveridge
    16. Epigenetics of Bipolar Disorder
    Gabriel Rodrigo Fries, Camila Nayane de Carvalho Lima, Erika Salarda and Omar Farookh Pinjari
    17. Epigenetics in Major Depressive Disorder
    James B. Potash
    18. The Epigenetics of Suicide: The Critical Impact of Environment on Epigenetic Regulation in Suicide
    Benoit Labonté, Gustavo Turecki and Pierre-Eric Lutz
    19. Epigenetics in Posttraumatic Stress Disorder
    Richard G. Hunter
    20. Epigenetics and Cognitive Disorders
    Fabio Coppedè and Andrea Stoccoro
    21. Epigenetics in Intellectual Disability
    Jamie M. Kramer, Nathalie Berube, Katherine Quesnel and Taryn Jakub
    22. Epigenetics and Pervasive Developmental Disorders
    Andrea Lynne Gropman
    23. Epigenetics in Child Psychiatry
    Josephine Elia
    24. Epigenetic Mechanisms of Drug Addiction Vulnerability
    Deena Marie Walker, Cari Bendersky and Allison Milian
    25. Epigenetics and Addiction to Alcohol
    Eleonora Gatta, Alessandro Guidotti and Vikram Saudagar

    Part 3: Epigenetics in the Therapy of Psychiatric Disorders
    26. Epigenetic Effects of Currently Used Psychotropic Drugs
    Jacob Peedicayil and Samuel Santosh
    27. DNA Methyltransferase Inhibitors and Psychiatric Disorders
    Marija Kundakovic
    28. Histone Deacetylase Inhibitors and Psychiatric Disorders
    Arvind Kumar
    29. Psychotherapy and Epigenetics in Psychiatry
    Anthony S. Zannas
    30. Gene-Specific Editing for Manipulating Specific Psychiatric Disorders
    Kristen J. Brennand

    Part 4: Other Topics in Epigenetics in Psychiatry
    31. Nutritional Effects on Epigenetics in Psychiatry
    Jacob Peedicayil
    32. Systems Biology and the Epigenetics of Psychiatric disorders
    Jacob Peedicayil
    33. Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
    Tamara Brook Franklin and Katharina Gapp
    34. Epigenetic Aspects of the Microbiome and Psychiatric Disorders
    Jacob Peedicayil and Samuel Santosh

Product details

  • No. of pages: 846
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 16, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128235782
  • Paperback ISBN: 9780128235775

About the Editors

Jacob Peedicayil

Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology.

Affiliations and Expertise

Professor, Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore

Dennis Grayson

Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institute in Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

Affiliations and Expertise

Professor of Molecular Neuroscience, University of Illinois at Chicago, IL, USA

Dimitri Avramopoulos

Dr. Dimitrios Avramopoulos received his MD from the University of Athens, Greece in 1990 and his PhD from the University of Crete in 1995 for his work on mapping human genes on chromosome 21 and deciphering the origin of chromosomal non-disjunction in trisomy 21, mentored by Dr Stylianos Antonarakis. He undertook his post-doctoral work at Johns Hopkins University where he became a faculty member in the Department of Psychiatry in 2002. He is currently on the faculty of the Department of Genetic Medicine and the Department of Psychiatry at Johns Hopkins University where he works on the genetics of psychiatric disorders. He is interested in the identification and functional follow up of disease-causing variants in the genome. He uses cellular models and genome editing to decipher the mechanisms through which disease - associated variants affect the brain, individually or in combinations, through the disruption of functional networks and the regulation of the corresponding genes.

Affiliations and Expertise

Associate Professor of Genetic Medicine, Johns Hopkins, Medicine, Baltimore, MD, USA

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