Epigenetics in Psychiatry

2nd Edition - August 21, 2021
Editors: Jacob Peedicayil, Dennis R. Grayson, Dimitri Avramopoulos
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 5 7 7 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 5 7 8 - 2

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing… Read more

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Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.

This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

Part 1: General Aspects of Epigenetics in Psychiatry

1. Introduction to Epigenetics in Psychiatry
Dimitrios Avramopoulos and Richard S. Lee

2. Outline of Epigenetics
Sebanti Ganguly, Trygve Tollefsbol and Bidisha Paul

3. A Brief History of Epigenetics in Psychiatry
Jacob Peedicayil

4. Roles of Epigenetics in the Neural Stem Cell and Neuron
Kinichi Nakashima

5. Role of Epigenetics in the Brain
Tania Roth, Stephanie Matt and Eric Roth

6. Epigenetic Epidemiology of Psychiatric Disorders
Monica Uddin and Jan Dahrendorff

7. ATAC-seq and Psychiatric Disorders
Panos Roussos

8. Single Cell RNA Sequencing and Psychiatric Disorders
W. Brad Ruzicka

9. Single Cell Analysis and Psychiatric Disorders
James H. Eberwine

10. Laboratory Techniques in Psychiatric Epigenetics
Chris Murgatroyd

11. Laboratory Epigenetic Models of Schizophrenia
Dennis R. Grayson and Jeffrey Dunn

12. Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
Jacob Peedicayil

Part 2: Epigenetics of Psychiatric Disorders

13. 5-Methycytosine and 5-Hydroxymethylcytosine in Schizophrenia
Dennis R. Grayson and Jeffrey Dunn

14. Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
Hamid M. Abdolmaleky

15. Non-Coding RNAs and Psychiatric Disorders
Jacob Peedicayil and Natalie J. Beveridge

16. Epigenetics of Bipolar Disorder
Gabriel Rodrigo Fries, Camila Nayane de Carvalho Lima, Erika Salarda and Omar Farookh Pinjari

17. Epigenetics in Major Depressive Disorder
James B. Potash

18. The Epigenetics of Suicide: The Critical Impact of Environment on Epigenetic Regulation in Suicide
Benoit Labonté, Gustavo Turecki and Pierre-Eric Lutz

19. Epigenetics in Posttraumatic Stress Disorder
Richard G. Hunter

20. Epigenetics and Cognitive Disorders
Fabio Coppedè and Andrea Stoccoro

21. Epigenetics in Intellectual Disability
Jamie M. Kramer, Nathalie Berube, Katherine Quesnel and Taryn Jakub

22. Epigenetics and Pervasive Developmental Disorders
Andrea Lynne Gropman

23. Epigenetics in Child Psychiatry
Josephine Elia

24. Epigenetic Mechanisms of Drug Addiction Vulnerability
Deena Marie Walker, Cari Bendersky and Allison Milian

25. Epigenetics and Addiction to Alcohol
Eleonora Gatta, Alessandro Guidotti and Vikram Saudagar

Part 3: Epigenetics in the Therapy of Psychiatric Disorders

26. Epigenetic Effects of Currently Used Psychotropic Drugs
Jacob Peedicayil and Samuel Santosh

27. DNA Methyltransferase Inhibitors and Psychiatric Disorders
Marija Kundakovic

28. Histone Deacetylase Inhibitors and Psychiatric Disorders
Arvind Kumar

29. Psychotherapy and Epigenetics in Psychiatry
Anthony S. Zannas

30. Gene-Specific Editing for Manipulating Specific Psychiatric Disorders
Kristen J. Brennand

Part 4: Other Topics in Epigenetics in Psychiatry

31. Nutritional Effects on Epigenetics in Psychiatry
Jacob Peedicayil

32. Systems Biology and the Epigenetics of Psychiatric disorders
Jacob Peedicayil

33. Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
Tamara Brook Franklin and Katharina Gapp

34. Epigenetic Aspects of the Microbiome and Psychiatric Disorders
Jacob Peedicayil and Samuel Santosh

Jacob Peedicayil

Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology.

Affiliations and expertise

Professor, Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, India

Dennis R. Grayson

Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institute in Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

Affiliations and expertise

Professor of Molecular Neuroscience, University of Illinois at Chicago, IL, USA

Dimitri Avramopoulos

Dr. Dimitrios Avramopoulos received his MD from the University of Athens, Greece in 1990 and his PhD from the University of Crete in 1995 for his work on mapping human genes on chromosome 21 and deciphering the origin of chromosomal non-disjunction in trisomy 21, mentored by Dr Stylianos Antonarakis. He undertook his post-doctoral work at Johns Hopkins University where he became a faculty member in the Department of Psychiatry in 2002. He is currently on the faculty of the Department of Genetic Medicine and the Department of Psychiatry at Johns Hopkins University where he works on the genetics of psychiatric disorders. He is interested in the identification and functional follow up of disease-causing variants in the genome. He uses cellular models and genome editing to decipher the mechanisms through which disease - associated variants affect the brain, individually or in combinations, through the disruption of functional networks and the regulation of the corresponding genes.

Affiliations and expertise

Associate Professor of Genetic Medicine, Johns Hopkins, Medicine, Baltimore, MD, USA