Epigenetics in Human Disease

Epigenetics in Human Disease

2nd Edition - May 18, 2018

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  • Editor: Trygve Tollefsbol
  • Hardcover ISBN: 9780128122150
  • eBook ISBN: 9780128123294

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Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

Key Features

  • Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
  • Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
  • Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
  • Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more


Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; advanced undergraduate students, graduate students, university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies

Table of Contents

  • Section I: Introduction
    1. Epigenetics in Human Disease

    Section II: Methodology
    2. Methods and Strategies to Determine Epigenetic Variation in Human Disease
    3. Age Estimates Using DNA Methylation Patterns
    4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing

    Section III: Human Cancer
    5. DNA Methylation Alterations in Human Cancers
    6. Alterations of Histone Modifications in Cancer
    7. MicroRNA in Cancer
    8. Epigenetic Approaches to Cancer Therapy

    Section lV: Neurological Disease
    9. Epigenomics in Neurobehavioral Disease
    10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
    11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease
    12. Epigenetic Modulation of Human Neurobiological Disorder

    Section V: Autoimmune Disease
    13. Epigenetic Basis of Autoimmune Disorders in Humans
    14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

    Section VI: Metabolic Disorders
    15. Epigenomic Factors in Human Obesity
    16. Epigenetic Approaches to Control Obesity
    17. Epigenetics of Diabetes in Humans
    18. The Potential of Epigenetic Compounds in Treating Diabetes

    Section VII: Other Disorders/Diseases
    19. Epigenetic Aberrations in Human Allergic Diseases
    20. Therapy of Airway Disease: Epigenetic Potential
    21. The Role of Epigenetics in Cardiovascular Disease
    22. Epigenetic Treatment Approaches to Cardiovascular Disease
    23. Epigenetics and Human Infectious Diseases
    24. Therapy of Infectious Diseases Using Epigenetic Approaches
    25. The Epigenetics of Endometriosis
    26. Epigenetic DNA Methylation in Endometrial Cancer
    27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases

    Section VIII: Development, Aging and Transgenerational Effects
    28. Epigenetics of Transgenerational Inheritance in Disease
    29. Epigenetic Mechanisms of Human Imprinting Disorders
    30. Therapeutic Approaches to Imprinting Diseases
    31. Stem Cell Epigenetics and Human Disease
    32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy
    33. Aging and Disease: The Epigenetic Bridge
    34. Epigenetic Programming of Human Disease and Aging

    Section lV: Future Research
    35. Future Directions in the Epigenetics of Human Disease

Product details

  • No. of pages: 1110
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: May 18, 2018
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128122150
  • eBook ISBN: 9780128123294

About the Editor

Trygve Tollefsbol

Trygve Tollefsbol
Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Professor of Biology and Senior Scientist, Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center; Comprehensive Diabetes Center, University of Alabama at Birmingham (UAB), USA

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