Epigenetics and Regeneration

Epigenetics and Regeneration

1st Edition - May 24, 2019

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  • Editor: Daniela Palacios
  • Hardcover ISBN: 9780128148792
  • eBook ISBN: 9780128148808

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Description

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics.

Key Features

  • Provides a foundational overview of epigenetics in regenerative medicine
  • Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice
  • Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways
  • Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Readership

Translational researchers; life science researchers, life science graduate students and postdocs; clinicians and graduate students in medical genetics; epigenetics; genomic medicine; regenerative medicine; stem cell biology; oncology; pathology; and biotechnology; developmental biologists; pharmacologists in industry and academia; osteologists; cardiologists; endocrinologists; pulmonologists, nephrologists, gastroenterologists, dermatologists, neuroscientists, medical chemists, molecular biologists; genetic counselors

Table of Contents

  • 1. Epigenetics and Regeneration: An Overview

    Section I: Epigenetics: molecular players and mechanisms
    2. Dynamics and mechanisms of DNA methylation reprogramming
    3. Histone modifications
    4. Non-coding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation
    5. Organizing Principles for the Spatial Folding of Chromosomes

    Section II: Development, Reprogramming & Tissue regeneration
    6. Epigenetics of early mammalian development: A Pathway to Regenerative Medicine
    7. Somatic Cell Epigenetic Reprogramming: Molecular Mechanisms and Therapeutic Potential
    8. Regenerative potential across species: An Eco-Evo-Devo Perspective

    Section III: Regenerative medicine: The epigenetics of tissue homeostasis, repair and regeneration
    9. Common challenges in tissue regeneration
    10. Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration
    11. Transcriptional and Epigenetic Mechanisms Controlling Intestinal Cell Fate
    12. Using Epigenetics as a Pharmacological Tool in Heart Regeneration
    13. Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease
    14. The Intrinsic Role of Epigenetics in Axonal Regeneration
    15. Insights Into the Epigenetics of Retinal Development and Diseases
    16. At the Intersection of Epigenetics and Regeneration: An Analysis of the Experimental Outlook of Organoid Technology

    Section IV: Epigenetics, regeneration and environment
    17. Epigenetic pharmacology in regenerative medicine (epi-drugs)
    18. Genomic and Epigenomic Potential With Age: Genome, Epigenome, and the Epigenetic Clock
    19. Epigenetics and Lifestyle: The Impact of Stress, Diet, and Social Habits on Tissue Homeostasis20.

    Section V: Conclusive Remarks
    20. iPSC- and Organoid-Based Biomedicine at the Intersection of Epigenetics and Regeneration: Charting the Normative Contours of Emerging Biomedical Platforms


     

Product details

  • No. of pages: 541
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: May 24, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128148792
  • eBook ISBN: 9780128148808

About the Series Volume Editor

Daniela Palacios

Dr. Daniela Palacios, PhD, is the director of the Epigenetics and Signal Transduction Laboratory at Fondazione Santa Lucia in Rome, Italy. She was trained as a molecular biologist in top academic and health institutions located in four different countries (Spain, UK, Italy, and USA). Research in her laboratory integrates state-of-the-art genomic and proteomic approaches with biochemistry, imaging, and novel RNA-based nanotechnologies to study how environmental stimuli modulate the epigenome during tissue regeneration and oncogenic transformation. The goal of the laboratory is to integrate basic research with innovative technological approaches to develop new tools for biomedical applications. Dr. Palacios has authored over 20 peer-reviewed articles and reviews on the subjects of epigenetics, development, and regeneration, including a chapter in Medical Epigenetics. In the past, she has participated as editor and guest editor to several journals within the fields of development and genomics.

Affiliations and Expertise

Director of the Epigenetics and Signal Transduction Laboratory at Fondazione Santa Lucia in Rome, Italy

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