Epigenetics and DNA Damage

Epigenetics and DNA Damage

1st Edition - August 15, 2022

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  • Editor: Miriam Jasiulionis
  • Paperback ISBN: 9780323910811

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Description

Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

Key Features

  • Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics
  • Features chapter contributions from leading international contributors
  • Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, and immunology; life science researchers; biotechnologists; developmental biologists. Clinicians and graduate students in the biosciences

Table of Contents

  • 1. Introduction Miriam Galvonas Jasiulionis
    2. DNA damage and DNA methylation
    3. DNA damage and histone modifications
    4. DNA damage and histone variants
    5. DNA damage and chromatin regulators
    6. DNA damage and miRNAs
    7. DNA damage and lncRNAs
    8. DNA damage, SIRT1 and epigenetic marks
    9. DNA damage, metabolic alterations and epigenetic changes
    10. DNA damage, diet and epigenetic changes
    11. DNA damage, epigenetics and aging
    12. DNA damage, epigenetics and pluripotent stem cell differentiation
    13. DNA damage, epigenetics and chronic inflammatory diseases
    14. DNA damage, epigenetic alterations and immune dysfunction
    15. DNA repair, epigenetics and trinucleotide repeat ataxias
    16. DNA damage, epigenetics and cancer
    17. Oncometabolites, epigenetic marks and DNA repair
    18. Therapies inducing DNA damage
    19. Epigenetic therapy
    20. Therapeutic strategies combining damage induction and epigenetic alterations
    21. Useful protocols to study DNA damage
    22. Useful protocols to study epigenetic modifications
    23. Interplay between DNA repair and epigenetics: Future directions

Product details

  • No. of pages: 408
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 15, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323910811

About the Editor

Miriam Jasiulionis

Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.

Affiliations and Expertise

Professor, Department of Pharmacology and Scientist, Laboratory of Ontogeny and Epigenetics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil

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