Epigenetic Regulation in the Nervous System

1st Edition

Basic Mechanisms and Clinical Impact

Print ISBN: 9780123914941
eBook ISBN: 9780123944054
Imprint: Academic Press
Published Date: 8th February 2013
Page Count: 374
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Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

Key Features

  • BMA Medical Book Awards 2014 - Highly Commended,  Neurology, British Medical Association
  • BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association
  • 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers
  • Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between
  • Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists
  • Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics


Researchers and advanced students in molecular/cellular, developmental and behavioral neuroscience; clinical neuroscientists; research psychiatrists and psychologists

Table of Contents


List of Contributors

Chapter 1. An Overview of the Molecular Basis of Epigenetics


DNA Modifications

Histone Modifications

Non-Coding RNAs

Non-Genic DNA

Prion-Based Epigenetic Inheritance

Epigenome Organization and Higher Order Chromatin Structures

Roles for Epigenetic Mechanisms in the Nervous System

Epigenetic Mechanisms in Nervous System Development

Neurogenesis in the Adult CNS

Circadian Rhythms

Persisting Effects of Life Experience: Nurturing and Transgenerational Effects

Epigenetic Mechanisms and Cellular Information Storage

Human Cognition and Cognitive Disorders

Summary – Active Regulation of Epigenetic Marks in the Nervous System


Chapter 2. Histone Modifications in the Nervous System and Neuropsychiatric Disorders


The Histone Code: Complex and Combinatorial

Other Epigenetic Mechanisms


The Histone Code in Learning, Memory and Synaptic Plasticity

The Histone Code in Neurological and Neuropsychiatric Disorders

Neurodevelopmental Disorders and Intellectual Disability

Mood Disorders




Chapter 3. Active DNA Demethylation and 5-Hydroxymethylcytosine


Regulation of Neuronal Gene Expression by Active DNA Demethylation

Active DNA Demethylation Mediated by DNA Repair

TET Proteins and an Oxidative Demethylation Pathway

Functions of TET Proteins and 5hmC Beyond DNA Demethylation

Role of Active DNA Demethylation in Neurological Disorders?

Concluding Remarks


Chapter 4. The Epigenetics of Parental Effects


Parent–Offspring Interactions and the Mental Health of the Offspring

Evolutionary Biology of Parental Signaling</P


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© Academic Press 2013
Academic Press
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2013 PROSE Awards - Winner, Single Volume Reference Works: Association of American Publishers, Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact PROSE Award 2013, Reference Work, Single Volume /Science: Biomedicine and Neuroscience, American Association of Publishers BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association PROSE Award 2013, Best in Reference Works, American Association of Publishers


"The book is primarily intended for advanced undergraduates, graduate students, active researchers and physician-scientists newly interested in the emerging field….Sweatt is also responsible for the book’s extensive illustrations, which are copies of his paintings depicting the role of epigenetic processes in the brain, and relate to work under way in his lab."--UAB News online, February 25, 2013
"Sweatt, Meaney, Nestler, and Akbarian present the first foundational work to address molecular, cellular, behavioral, and clinical roles for epigenetic mechanisms in the nervous system…This unique book is targeted for physicians and scientists, as well as researchers and students."--Reference & Research Book News, October 2013