- Print ISBN 9780123914941
- Electronic ISBN 9780123944054
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.
Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.
Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.
Researchers and advanced students in molecular/cellular, developmental and behavioral neuroscience; clinical neuroscientists; research psychiatrists and psychologists
List of Contributors
Chapter 1. An Overview of the Molecular Basis of Epigenetics
Prion-Based Epigenetic Inheritance
Epigenome Organization and Higher Order Chromatin Structures
Roles for Epigenetic Mechanisms in the Nervous System
Epigenetic Mechanisms in Nervous System Development
Neurogenesis in the Adult CNS
Persisting Effects of Life Experience: Nurturing and Transgenerational Effects
Epigenetic Mechanisms and Cellular Information Storage
Human Cognition and Cognitive Disorders
Summary – Active Regulation of Epigenetic Marks in the Nervous System
Chapter 2. Histone Modifications in the Nervous System and Neuropsychiatric Disorders
The Histone Code: Complex and Combinatorial
Other Epigenetic Mechanisms
The Histone Code in Learning, Memory and Synaptic Plasticity
The Histone Code in Neurological and Neuropsychiatric Disorders
Neurodevelopmental Disorders and Intellectual Disability
Chapter 3. Active DNA Demethylation and 5-Hydroxymethylcytosine
Regulation of Neuronal Gene Expression by Active DNA Demethylation
Active DNA Demethylation Mediated by DNA Repair
TET Proteins and an Oxidative Demethylation Pathway
Functions of TET Proteins and 5hmC Beyond DNA Demethylation
Role of Active DNA Demethylation in Neurological Disorders?
Chapter 4. The Epigenetics of Parental Effects
Parent–Offspring Interactions and the Mental Health of the Offspring
Evolutionary Biology of Parental Signaling
"The book is primarily intended for advanced undergraduates, graduate students, active researchers and physician-scientists newly interested in the emerging field….Sweatt is also responsible for the book’s extensive illustrations, which are copies of his paintings depicting the role of epigenetic processes in the brain, and relate to work under way in his lab."--UAB News online, February 25, 2013